Polo-like kinase 4: A molecular linchpin in cancer and its management [PDF]
iScienceSummary: Genomic instability and cell cycle dysregulation are considered hallmarks of cancer. Polo-like kinase 4 (PLK4), a member of the PLK family, is essential for faithful centriole duplication, which, when dysregulated, contributes to genomic ...
Durdana Muntaqua +3 more
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High expression of polo-like kinase 4 predicts worse progression-free survival in diffuse large B cell lymphoma patients treated with R-CHOP [PDF]
World Journal of Surgical OncologyBackground Polo-like kinase 4 (PLK4) has been shown to be a tumor-promoting factor with multiple impacts on cancer growth, invasiveness, and treatment sensitivity.
Dehong Xu +4 more
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Polo-like Kinase 4: A Molecular Culprit in Skin Cancer Pathogenesis [PDF]
CellsSkin cancer remains a significant global health challenge, with rising incidence and associated mortality in late-stage and drug-resistant cases. This underscores a continuing need for more effective novel therapeutic options that can be utilized for ...
Tanya Jaiswal +2 more
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Discovery of novel dual-targeting inhibitors against PLK1-PBD and PLK4-PB3: structure-guided pharmacophore modelling, virtual screening, molecular docking, molecular dynamics simulation, and biological evaluation [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryAberrant expression of PLK1 and PLK4 is closely associated with tumourigenesis, and their simultaneous inhibition can effectively suppress tumour proliferation.
Changhao Zhao +6 more
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Gene expression patterns in heterozygous
BMC Genomics, 2009 Background The polo-like kinases (Plks) are a group of serine/threonine kinases which have roles in many aspects of cellular function including the regulation of mitotic activity and cellular stress responses.
Nantais Jordan +3 more
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A self-assembled cylindrical platform for Plk4-induced centriole biogenesis [PDF]
Open Biology, 2020 The centrosome, a unique membraneless multiprotein organelle, plays a pivotal role in various cellular processes that are critical for promoting cell proliferation.
Kyung S. Lee +4 more
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Polo-like kinase 4 as a potential predictive biomarker of chemoradioresistance in locally advanced rectal cancer [PDF]
Journal of Pathology and Translational Medicine, 2022 Background Polo-like kinase 4 (PLK4) is a serine/threonine protein kinase located in the centriole of the chromosome during the cell cycle. PLK4 overexpression has been described in a variety of many common human epithelial tumors.
Hyunseung Oh +8 more
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Polo-Like Kinase 4’s Critical Role in Cancer Development and Strategies for Plk4-Targeted Therapy
Frontiers in Oncology, 2021 Polo-like kinases (Plks) are critical regulatory molecules during the cell cycle process. This family has five members: Plk1, 2, 3, 4, and 5. Plk4 has been identified as a master regulator of centriole replication, and its aberrant expression is closely ...
Xiaoyang Zhang +3 more
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Frontiers in Oncology, 2022 Tumor immune microenvironment plays an important role in tumorigenesis and metastasis. Polo-like kinases 4 (PLK4) is a crucial regulatory factor in the process of cell cycle, and its abnormal regulation often leads to a variety of diseases including ...
Xiaoyang Zhang +8 more
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FEBS Open Bio, 2021 Polo‐like kinase 4 (PLK4) has been reported to contribute to tumor growth, invasion, and metastasis. However, the role of PLK4 in human bladder cancer (BC) remains unclear.
Ziyi Yang +6 more
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