Results 91 to 100 of about 3,466 (159)

Inactivation of PLK4-STIL Module Prevents Self-Renewal and Triggers p53-Dependent Differentiation in Human Pluripotent Stem Cells

open access: yesStem Cell Reports, 2018
Summary: Centrioles account for centrosomes and cilia formation. Recently, a link between centrosomal components and human developmental disorders has been established.
Tereza Renzova   +6 more
doaj   +1 more source

Atypical function of a centrosomal module in WNT signalling drives contextual cancer cell motility

open access: yesNature Communications, 2019
Centrosomes control cell motility, polarity and migration that is thought to be mediated by their microtubule-organizing capacity. Here we demonstrate that WNT signalling drives a distinct form of non-directional cell motility that requires a key ...
Yi Luo   +11 more
doaj   +1 more source

Human Plk4 phosphorylates Cdc25C [PDF]

open access: yesCell Cycle, 2008
Sepal Bonni   +3 more
openaire   +1 more source

Centrosome amplification and aneuploidy driven by the HIV-1-induced Vpr•VprBP•Plk4 complex in CD4+ T cells

open access: yesNature Communications
HIV-1 infection elevates the risk of developing various cancers, including T-cell lymphoma. Whether HIV-1-encoded proteins directly contribute to oncogenesis remains unknown.
Jung-Eun Park   +15 more
doaj   +1 more source

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