Results 11 to 20 of about 3,466 (159)

Polo-like kinases and UV-induced skin carcinogenesis: What we know and what's next. [PDF]

Photochem Photobiol
The polo‐like kinase (PLK) family plays distinct and critical roles in the regulation of cell cycle progression, and its dysregulation has been implicated in various cancers. Ultraviolet (UV) radiation is a well‐established environmental factor in the development of skin cancer.
Jaiswal T, Muntaqua D, Chhabra G, Ahmad N.   +3 more
europepmc   +2 more sources

PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential. [PDF]

Cytoskeleton (Hoboken)
ABSTRACT Centrosomes catalyze the assembly of a microtubule‐based bipolar spindle, essential for the precise chromosome segregation during cell division. At the center of this process lies Polo‐Like Kinase 4 (PLK4), the master regulator that controls the duplication of the centriolar core to ensure the correct balance of two centrosomes per dividing ...
Hamzah M, Meitinger F, Ohta M.
europepmc   +2 more sources

Target Binding of Black Phosphorus Nanomaterial to Polo-Like Kinase 1 for Cancer Chemotherapy: A Mutual Selection of Nanomaterial and Protein. [PDF]

Exploration (Beijing)
This study investigates the effect of protein properties on the nanomaterial‐protein interaction and elucidates the molecular mechanisms underlying the targeted inhibition of polo‐like kinase (PLK1) by black phosphorus nanomaterials (BPNMs). The specific targeting inhibition is attributed to the intrinsic properties of both the PLK1 protein and the ...
Liu F, Li ZD, Zeng Y, Wang X, Liu Y, Li Q, Luo W, Suo X, Xu Y, Yuan F, Zhang D, Zhang W, Geng S, Yu XF, Zhang G, Li Y.   +15 more
europepmc   +2 more sources

Sak/Plk4 and mitotic fidelity [PDF]

Oncogene, 2005
Sak/Plk4 differs from other polo-like kinases in having only a single polo box, which assumes a novel dimer fold that localizes to the nucleolus, centrosomes and the cleavage furrow. Sak expression increases gradually in S through M phase, and Sak is destroyed by APC/C dependent proteolysis.
Carol J, Swallow, Michael A, Ko, Najeeb U, Siddiqui, John W, Hudson, James W, Dennis   +4 more
openaire   +2 more sources

Plk4-Induced Centriole Biogenesis in Human Cells [PDF]

Developmental Cell, 2007
We show that overexpression of Polo-like kinase 4 (Plk4) in human cells induces centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole. This provided an opportunity for dissecting centriole assembly and characterizing assembly intermediates.
Kleylein-Sohn, Julia, Westendorf, Jens, Le Clech, Mikael, Habedanck, Robert, Stierhof, York-Dieter, Nigg, Erich A.   +5 more
openaire   +3 more sources

Effects of the PLK4 inhibitor Centrinone on the biological behaviors of acute myeloid leukemia cell lines

Frontiers in Genetics, 2022
Polo-like kinase 4 (PLK4), a key regulator of centriole biogenesis, is frequently overexpressed in cancer cells. However, roles and the mechanism of PLK4 in the leukemiagenesis of acute myeloid leukemia (AML) remain unclear.
Xing-Ru Mu, Meng-Meng Ma, Zi-Yi Lu, Jun Liu, Yu-Tong Xue, Jiang Cao, Ling-Yu Zeng, Feng Li, Kai-Lin Xu, Kai-Lin Xu, Qing-Yun Wu, Qing-Yun Wu   +11 more
doaj   +1 more source

Centriole Duplication: When PLK4 Meets Ana2/STIL [PDF]

Current Biology, 2014
Polo-like kinase 4 is known to drive centriole duplication, but the relevant substrate remains elusive. A new study shows that PLK4 phosphorylates a key centriolar component, Ana2/STIL, to initiate centriole assembly.
Kim, Minhee, Fong, Chii Shyang, Bryan Tsou, Meng-Fu   +2 more
openaire   +2 more sources

Inhibition of Polo-like kinase 4 induces mitotic defects and DNA damage in diffuse large B-cell lymphoma

Cell Death and Disease, 2021
Polo-like kinase 4 (PLK4), a key regulator of centriole biogenesis, has recently been shown to play key roles in tumorigenesis. Blocking PLK4 expression by interference or targeted drugs exhibits attractive potential in improving the efficacy of ...
Yi Zhao, Juan Yang, Jiarui Liu, Yiqing Cai, Yang Han, Shunfeng Hu, Shuai Ren, Xiangxiang Zhou, Xin Wang   +8 more
doaj   +1 more source

TRIM37 controls cancer-specific vulnerability to PLK4 inhibition [PDF]

Nature, 2020
Centrosomes catalyse the formation of microtubules needed to assemble the mitotic spindle apparatus1. Centrosomes themselves duplicate once per cell cycle, in a process that is controlled by the serine/threonine protein kinase PLK4 (refs. 2,3). When PLK4 is chemically inhibited, cell division proceeds without centrosome duplication, generating ...
Franz Meitinger, Midori Ohta, Kian-Yong Lee, Sadanori Watanabe, Robert L. Davis, John V. Anzola, Ruth Kabeche, David A. Jenkins, Andrew K. Shiau, Arshad Desai, Karen Oegema   +10 more
openaire   +4 more sources

Synthetic lethality in cancer therapy: Mechanisms, models and clinical translation for overcoming therapeutic resistance. [PDF]

Clin Transl Med
Application of synthetic lethality screening in drug resistance models. Abstract Background and Rationale Synthetic lethality (SL)‐based strategies hold significant promise for overcoming therapeutic resistance, a critical bottleneck in cancer treatment where cancer cells evade anticancer therapies, leading to diminished efficacy or treatment failure ...
Li J, Zhang L, Shang Y, Liu J, Zhao H.
europepmc   +2 more sources