Results 21 to 30 of about 3,466 (159)
Downregulation of polo-like kinase 4 in hepatocellular carcinoma associates with poor prognosis. [PDF]
PLoS ONE, 2012 Polo-like kinase 4 (PLK4), belonging to serine/threonine kinase family, is critical for centriole replication and cell cycle progression. PLK4 has been proposed as a tumor suppressor in hepatocellular carcinoma (HCC).
Lili Liu +5 more
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iScience, 2018 Summary: Centrioles, the cores of centrosomes and cilia, duplicate every cell cycle to ensure their faithful inheritance. How only a single procentriole is produced on each mother centriole remains enigmatic.
Marcin Leda +2 more
doaj +1 more source
Two-step phosphorylation of Ana2 by Plk4 is required for the sequential loading of Ana2 and Sas6 to initiate procentriole formation [PDF]
Open Biology, 2017 The conserved process of centriole duplication requires Plk4 kinase to recruit and promote interactions between Sas6 and Sas5/Ana2/STIL (respective nomenclature of worms/flies/humans).
Nikola S. Dzhindzhev +6 more
doaj +1 more source
STIL binding to Polo-box 3 of PLK4 regulates centriole duplication
eLife, 2015 Polo-like kinases (PLK) are eukaryotic regulators of cell cycle progression, mitosis and cytokinesis; PLK4 is a master regulator of centriole duplication.
Christian Arquint +7 more
doaj +1 more source
Global cellular response to chemical perturbation of PLK4 activity and abnormal centrosome number
eLife, 2022 Centrosomes act as the main microtubule organizing center (MTOC) in metazoans. Centrosome number is tightly regulated by limiting centriole duplication to a single round per cell cycle.
Johnny M Tkach +5 more
doaj +1 more source
A cis‐eQTL genetic variant in PLK4 confers high risk of hepatocellular carcinoma
Cancer Medicine, 2019 Purpose The overexpression and knockdown of PLK4 were both reported to generate aneuploidy. Thus, we aimed to investigate whether genetic variants in PLK4 contribute to the development of hepatocellular carcinoma (HCC).
Lijuan Meng +15 more
doaj +1 more source
Asterless amplifies Plk4 [PDF]
Journal of Cell Biology, 2015 ![Figure][1] Superresolution microscopy shows the structure of stable aggregates formed by overexpressed Plk4 (green) and Asl (red). [Klebba and Galletta et al.][2] reveal that the scaffold protein Asterless (Asl) regulates centriole duplication by controlling turnover of the kinase ...
openaire +1 more source
PLK4 trans-Autoactivation Controls Centriole Biogenesis in Space [PDF]
Developmental Cell, 2015 Centrioles are essential for cilia and centrosome assembly. In centriole-containing cells, centrioles always form juxtaposed to pre-existing ones, motivating a century-old debate on centriole biogenesis control. Here, we show that trans-autoactivation of Polo-like kinase 4 (PLK4), the trigger of centriole biogenesis, is a critical event in the spatial ...
Carla A.M. Lopes +12 more
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Plk4 Is a Novel Substrate of Protein Phosphatase 5
International Journal of Molecular Sciences, 2023 The conserved Ser/Thr protein phosphatase 5 (PP5) is involved in the regulation of key cellular processes, including DNA damage repair and cell division in eukaryotes. As a co-chaperone of Hsp90, PP5 has been shown to modulate the maturation and activity of numerous oncogenic kinases.
Edit Ábrahám +4 more
openaire +3 more sources
Cell Death and Disease, 2023 Polo-like kinase 4 (Plk4), the major regulator of centriole biogenesis, has emerged as a putative therapeutic target in cancer due to its abnormal expression in human carcinomas, leading to centrosome number deregulation, mitotic defects and chromosomal ...
Irina Fonseca +6 more
doaj +1 more source