Results 31 to 40 of about 3,466 (159)

Bimodal Binding of STIL to Plk4 Controls Proper Centriole Copy Number

Cell Reports, 2018
Summary: The number of centrioles is tightly controlled to ensure bipolar spindle assembly, which is a prerequisite to maintain genome integrity. However, our understanding of the fundamental principle that governs the formation of a single procentriole ...
Midori Ohta, Koki Watanabe, Tomoko Ashikawa, Yuka Nozaki, Satoko Yoshiba, Akatsuki Kimura, Daiju Kitagawa   +6 more
doaj   +1 more source

Plk4-dependent phosphorylation of STIL is required for centriole duplication

Biology Open, 2015
Duplication of centrioles, namely the formation of a procentriole next to the parental centriole, is regulated by the polo-like kinase Plk4. Only a few other proteins, including STIL (SCL/TAL1 interrupting locus, SIL) and Sas-6, are required for the ...
Anne-Sophie Kratz, Felix Bärenz, Kai T. Richter, Ingrid Hoffmann   +3 more
doaj   +1 more source

Mechanistic study on PLK4 regulation of invasion, proliferation and apoptosis in oral squamous cell carcinoma [PDF]

Zhongguo aizheng zazhi
Background and purpose: Polo-like kinase 4 (PLK4) is a cell cycle regulatory protein, which is closely related to the occurrence and development of a variety of malignant tumors.
QIN Huan, WANG Jie, YANG Jie, HUA Yingjie, QU Huijuan, JI Honghai
doaj   +1 more source

CFI-400945 is not a selective cellular PLK4 inhibitor [PDF]

Proceedings of the National Academy of Sciences, 2018
In the PNAS paper “Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers,” Kawakami et al. (1) treat lung cancer cell lines and mouse tumor models with the small molecule CFI-400945 and interpret its effects as being solely due to inhibition of Polo-like kinase 4 (PLK4), the kinase essential for centrosome duplication (2)
Karen Oegema, Robert L. Davis, Pablo Lara-Gonzalez, Arshad Desai, Andrew K. Shiau   +4 more
openaire   +2 more sources

Polo-Like Kinase 4 (PLK4) Is Overexpressed in Central Nervous System Neuroblastoma (CNS-NB)

Bioengineering, 2018
Neuroblastoma (NB) is the most common extracranial solid tumor in pediatrics, with rare occurrences of primary and metastatic tumors in the central nervous system (CNS).
Anders W. Bailey, Amreena Suri, Pauline M. Chou, Tatiana Pundy, Samantha Gadd, Stacey L. Raimondi, Tadanori Tomita, Simone Treiger Sredni   +7 more
doaj   +1 more source

Plk4 triggers autonomous de novo centriole biogenesis and maturation

Journal of Cell Biology, 2020
Centrioles form centrosomes and cilia. In most proliferating cells, centrioles assemble through canonical duplication, which is spatially, temporally, and numerically regulated by the cell cycle and the presence of mature centrioles. However, in certain cell types, centrioles assemble de novo, yet by poorly understood mechanisms. Herein, we established
Nabais, Catarina, Pessoa, Delphine, de-Carvalho, Jorge, van Zanten, Thomas, Duarte, Paulo, Mayor, Satyajit, Carneiro, Jorge, Telley, Ivo A., Bettencourt-Dias, Mónica   +8 more
openaire   +2 more sources

Fast and furious . . . or not, Plk4 dictates the pace [PDF]

Journal of Cell Biology, 2018
In each duplication cycle, daughter centrioles grow to the same length as their mothers. Which mechanisms regulate this fidelity to maintain centriole length is not known. In this issue, Aydogan et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201801014) report a novel role for Polo-like kinase 4 (Plk4).
Gemble, Simon, Basto, Renata
openaire   +2 more sources

Polo-like kinase 4: the odd one out of the family

Cell Division, 2010
Polo-like kinase 4 (PLK4) is a unique member of the Polo-like family of kinases that shares little homology with its siblings and has an essential role in centriole duplication.
Bornens Michel, Sillibourne James E
doaj   +1 more source

Novel spirooxindole compounds as anticancer agents: targeting Plk4 kinase through design, synthesis, and molecular docking [PDF]

Pharmacia
Plk4 plays a crucial role in controlling the duplication of centrioles and initiating the creation of centrosomes. Disruption of Plk4 leads to aneuploidy and chromosome instability, contributing to aggressive cancers, as well as microcephaly and fatal ...
Mervat S. Sammor, Almeqdad Y. Habashneh, Mahmoud A. Al-Sha'er, Sanaa K. Bardaweel, Mustafa M. El‐Abadelah   +4 more
doaj   +3 more sources

PLK4 inhibitor exhibits antitumor effect and synergizes sorafenib via arresting cell cycle and inactivating Wnt/β-catenin pathway in anaplastic thyroid cancer

Cancer Biology & Therapy, 2023
The anti-tumor effect of polo-like kinase 4 (PLK4) inhibitor has been explored in several solid carcinomas, while its application in anaplastic thyroid cancer (ATC) remains scarce.
Wei Zhu, Bin Xie
doaj   +1 more source