Results 41 to 50 of about 3,466 (159)

PLK4 drives centriole amplification and apical surface area expansion in multiciliated cells

eLife, 2022
Multiciliated cells (MCCs) are terminally differentiated epithelia that assemble multiple motile cilia used to promote fluid flow. To template these cilia, MCCs dramatically expand their centriole content during a process known as centriole amplification.
Gina M LoMastro, Chelsea G Drown, Aubrey L Maryniak, Cayla E Jewett, Margaret A Strong, Andrew Jon Holland   +5 more
doaj   +1 more source

Structural and Functional Analyses of the FAM46C/Plk4 Complex

Structure, 2020
FAM46C, a non-canonical poly(A) polymerase, is frequently mutated in multiple myeloma. Loss of function of FAM46C promotes cell survival of multiple myeloma, suggesting a tumor-suppressive role. FAM46C is also essential for fastening sperm head and flagellum, indispensable for male fertility. The molecular mechanisms of these functions of FAM46C remain
Hua, Chen, Defen, Lu, Guijun, Shang, Guoming, Gao, Xuewu, Zhang   +4 more
openaire   +2 more sources

PLK4-phosphorylated NEDD1 facilitates cartwheel assembly and centriole biogenesis initiations [PDF]

Journal of Cell Biology, 2020
Centrosome duplication occurs under strict spatiotemporal regulation once per cell cycle, and it begins with cartwheel assembly and daughter centriole biogenesis at the lateral sites of the mother centrioles. However, although much of this process is understood, how centrosome duplication is initiated remains unclear.
Wangfei Chi, Gang Wang, Guangwei Xin, Qing Jiang, Chuanmao Zhang   +4 more
openaire   +2 more sources

The use of deidentified organ donor testes for research

Andrology, EarlyView.
Abstract Our knowledge of testis development and function mainly comes from research using mammalian model organisms, primarily the mouse. However, there are integral differences between men and other mammalian species regarding cellular composition and expression profiles during fetal and post‐natal testis development and in the mature testis ...
Marina V. Pryzhkova, Marnie W. Skinner, Juliana I. Candelaria, Stephen R. Wellard, Philip W. Jordan   +4 more
wiley   +1 more source

Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse [PDF]

Open Biology, 2015
To address the long-known relationship between supernumerary centrosomes and cancer, we have generated a transgenic mouse that permits inducible expression of the master regulator of centriole duplication, Polo-like-kinase-4 (Plk4).
Paula A. Coelho, Leah Bury, Marta N. Shahbazi, Kifayathullah Liakath-Ali, Peri H. Tate, Sam Wormald, Christopher J. Hindley, Meritxell Huch, Joy Archer, William C. Skarnes, Magdalena Zernicka-Goetz, David M. Glover   +11 more
doaj   +1 more source

Interaction interface in the C-terminal parts of centriole proteins Sas6 and Ana2 [PDF]

Open Biology, 2020
The centriole is a ninefold symmetrical structure found at the core of centrosomes and, as a basal body, at the base of cilia, whose conserved duplication is regulated by Plk4 kinase.
Agnieszka Fatalska, Nikola S. Dzhindzhev, Michal Dadlez, David M. Glover   +3 more
doaj   +1 more source

PLK4 is a potential therapeutic target in nonmelanoma skin cancers: Evidence from molecular and in vivo studies

Photochemistry and Photobiology, EarlyView.
Exposure to solar ultraviolet radiation is the main etiologic driver of nonmelanoma skin cancers (NMSCs), including basal cell (BCC) and cutaneous squamous cell carcinomas (cSCC), which are the most prevalent types of cancers in the US. In this study, we demonstrate that the serine/threonine kinase Polo‐like kinase 4 (PLK4) is overexpressed in NMSCs ...
Mary A. Ndiaye, Debra R. Garvey, Gagan Chhabra, Chandra K. Singh, Minakshi Nihal, Nihal Ahmad   +5 more
wiley   +1 more source

SNHG16 promotes tumorigenesis and cisplatin resistance by regulating miR-338-3p/PLK4 pathway in neuroblastoma cells

Cancer Cell International, 2020
Background Long noncoding RNA small nucleolar RNA host gene 16 (lncRNA SNHG16) has been revealed to be involved in the tumorigenesis of neuroblastoma.
Zhaoying Xu, Yongfa Sun, Danfeng Wang, Huifang Sun, Xiaojun Liu   +4 more
doaj   +1 more source

PLK4 phosphorylation of CP110 is required for efficient centriole assembly [PDF]

Cell Cycle, 2017
Centrioles are assembled during S phase and segregated into 2 daughter cells at the end of mitosis. The initiation of centriole assembly is regulated by polo-like kinase 4 (PLK4), the major serine/threonine kinase in centrioles. Despite its importance in centriole duplication, only a few substrates have been identified, and the detailed mechanism of ...
Miseon, Lee, Mi Young, Seo, Jaerak, Chang, Deog Su, Hwang, Kunsoo, Rhee   +4 more
openaire   +2 more sources

KIFC1 is Associated With Sarcomatoid Differentiation, Immune Response, and a Poor Prognosis in Clear Cell Renal Cell Carcinoma

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Introduction Centrosome clustering is a cancer‐specific adaptation that allows cells with centrosome amplification to evade mitotic catastrophe and has emerged as a potential therapeutic target. We analyzed the prognostic role of several molecules related to centrosome clustering and found that Kinesin Family Member C1 (KIFC1) was strongly ...
Yoshinori Nakano, Yohei Sekino, Go Kobayashi, Hikaru Nakahara, Shintaro Akabane, Kenshiro Takemoto, Miki Naito, Shunsuke Miyamoto, Kohei Kobatake, Hiroyuki Kitano, Keisuke Goto, Akihiro Goriki, Keisuke Hieda, Takao Hinoi, Nobuyuki Hinata   +14 more
wiley   +1 more source