Results 51 to 60 of about 3,466 (159)
SAK/PLK4 Is Required for Centriole Duplication and Flagella Development [PDF]
Current Biology, 2005 SAK/PLK4 is a distinct member of the polo-like kinase family. SAK-/- mice die during embryogenesis, whereas SAK+/- mice develop liver and lung tumors and SAK+/- MEFs show mitotic abnormalities. However, the mechanism underlying these phenotypes is still not known.Here, we show that downregulation of SAK in Drosophila cells, by mutation or RNAi, leads ...
BETTENCOURT DIAS M. +9 more
openaire +5 more sources
LZTS2 Negatively Regulates Centrosomal CEP135 Levels and Microtubule Nucleation
Cytoskeleton, Volume 83, Issue 3, Page 128-139, March 2026.ABSTRACT The microtubule cytoskeleton is a fundamental functional component of the cell. In vertebrate proliferating cells, centrosomes are the primary microtubule organizing center (MTOC), and their dysregulation has been linked to genomic instability and cancer.
Catarina Peneda +4 more
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 6, March 2026.ABSTRACT The APOE gene, which encodes Apolipoprotein E (ApoE), is the strongest genetic risk locus for Alzheimer's disease (AD). A substantial fraction of AD risk genes converges on pathways controlling lipid metabolism and immune regulation, in which microglia serve as a central integrative hub in the brain.
Dayoung Kim +6 more
wiley +1 more source
Regulation of Autophosphorylation Controls PLK4 Self-Destruction and Centriole Number [PDF]
Current Biology, 2013 Polo-like kinase 4 (PLK4) is a major player in centriole biogenesis: in its absence centrioles fail to form, while in excess leads to centriole amplification. The SCF-Slimb/βTrCP-E3 ubiquitin ligase controls PLK4 levels through recognition of a conserved phosphodegron.
Cunha-Ferreira I +13 more
openaire +2 more sources
Molecular Cancer, 2011 Background Infection with high-risk human papillomaviruses (HPVs) such as HPV-16 is intimately associated with squamous cell carcinomas (SCCs) of the anogenital tract and a subset of oropharyngeal carcinomas.
Duensing Stefan +2 more
doaj +1 more source
The E3 ubiquitin ligase Mib1 regulates Plk4 and centriole biogenesis [PDF]
Journal of Cell Science, 2015 Centrioles function as core components of centrosomes and as basal bodies for the formation of cilia and flagella. Thus, effective control of centriole numbers is essential for embryogenesis, tissue homeostasis, and genome stability. In mammalian cells, the centriole duplication cycle is governed by Polo-like kinase 4 (Plk4).
Cajanek, Lukas +2 more
openaire +6 more sources
The FASEB Journal, Volume 40, Issue 4, 28 February 2026.Growth hormone (GH) activates GHR at the primary cilium and stimulates centrosomal JAK2. JAK2 centrosomal localization requires both its SH2 domain and kinase activity. Cells expressing JAK2 variants deficient in centrosomal targeting show impaired control of cilia length, reduced proliferation, and cell migration compared with parental and JAK2 WT ...
Gaurab Karki +7 more
wiley +1 more source
CDK11(p58) is required for centriole duplication and Plk4 recruitment to mitotic centrosomes. [PDF]
PLoS ONE, 2011 BACKGROUND: CDK11(p58) is a mitotic protein kinase, which has been shown to be required for different mitotic events such as centrosome maturation, chromatid cohesion and cytokinesis.
Nathalie Franck +5 more
doaj +1 more source
CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole Biogenesis [PDF]
Current Biology, 2016 Centrioles are essential for the assembly of both centrosomes and cilia. Centriole biogenesis occurs once and only once per cell cycle and is temporally coordinated with cell-cycle progression, ensuring the formation of the right number of centrioles at the right time.
Zitouni, Sihem +16 more
openaire +4 more sources
Cep152 and Plk4 form a double act [PDF]
Journal of Cell Biology, 2010 Two centrosomal proteins work together to duplicate centrioles.
openaire +1 more source