Results 61 to 70 of about 3,466 (159)

Cep152 interacts with Plk4 and is required for centriole duplication [PDF]

Journal of Cell Biology, 2010
Centrioles are microtubule-based structures that organize the centrosome and nucleate cilia. Centrioles duplicate once per cell cycle, and duplication requires Plk4, a member of the Polo-like kinase family; however, the mechanism linking Plk4 activity and centriole formation is unknown. In this study, we show in human and frog cells that Plk4 interacts
Hatch, Emily M, Kulukian, Anita, Holland, Andrew J, Cleveland, Don W, Stearns, Tim   +4 more
openaire   +4 more sources

Lysine demethylase 4A: from chromatin to centrosomes

The FEBS Journal, Volume 293, Issue 2, Page 392-395, January 2026.
The lysine demethylase 4A (KDM4A) remodels chromatin by histone demethylation, regulating gene expression. In this issue, Chowdhury et al. report a previously undescribed localisation for KDM4A outside the nucleus, at the pericentriolar material around the centrosome.
Anushka Sharma, Ruth M. Kearney, Ciaran G. Morrison   +2 more
wiley   +1 more source

PLK4 promotes centriole duplication by phosphorylating STIL to link the procentriole cartwheel to the microtubule wall

eLife, 2019
Centrioles play critical roles in organizing the assembly of the mitotic spindle and templating the formation of primary cilia. Centriole duplication occurs once per cell cycle and is regulated by Polo-like kinase 4 (PLK4).
Tyler Chistopher Moyer, Andrew Jon Holland   +1 more
doaj   +1 more source

Identification of Host Kinase Genes Required for Influenza Virus Replication and the Regulatory Role of MicroRNAs. [PDF]

PLoS ONE, 2013
Human protein kinases (HPKs) have profound effects on cellular responses. To better understand the role of HPKs and the signaling networks that influence influenza virus replication, a small interfering RNA (siRNA) screen of 720 HPKs was performed.
Abhijeet Bakre, Lauren E Andersen, Victoria Meliopoulos, Keegan Coleman, Xiuzhen Yan, Paula Brooks, Jackelyn Crabtree, S Mark Tompkins, Ralph A Tripp   +8 more
doaj   +1 more source

Centrosomal protein 120 promotes centrosome amplification and gastric cancer progression via USP54-mediated deubiquitination of PLK4

iScience, 2023
Summary: Centrosomal protein 120 (CEP120) is a 120 kDa centrosome protein that plays an important role in centrosome replication. Overexpression of CEP120 can lead to centrosome duplicate abnormality, which is closely associated with tumorigenesis and ...
Chenggang Zhang, Xianxiong Ma, Guanxin Wei, Xiuxian Zhu, Peng Hu, Xiang Chen, Dianshi Wang, Yuan Li, Tuo Ruan, Weikang Zhang, Kaixiong Tao, Chuanqing Wu   +11 more
doaj   +1 more source

Plk4/SAK/ZYG-1 in the regulation of centriole duplication [PDF]

F1000 Biology Reports, 2010
Centrioles organize both centrosomes and cilia. Centriole duplication is tightly regulated and coordinated with the cell cycle to limit duplication to only once per cell cycle. Defects in centriole number and structure are commonly found in cancer. Plk4/SAK and the functionally related Caenorhabditis elegans ZYG-1 kinases initiate centriole duplication.
Pearson, Chad G, Winey, Mark
openaire   +2 more sources

Phase Separation of PHLDB2 Drives EMT and Tumor Progression in Triple‐Negative Breast Cancer

Cancer Medicine, Volume 14, Issue 23, December 2025.
ABSTRACT Background Liquid–liquid phase separation (LLPS) has emerged as a critical mechanism underlying oncogenic signaling and transcriptional regulation; however, its involvement in triple‐negative breast cancer (TNBC) remains largely unknown.
Min Zhang, Chanjin Liang, Ting Chen, Xingyuan Shi, Jiqing Hao   +4 more
wiley   +1 more source

Aberrant methylation of Polo-like kinase CpG islands in Plk4 heterozygous mice

BMC Cancer, 2011
Background Hepatocellular carcinoma (HCC), one of the most common cancers world-wide occurs twice as often in men compared to women. Predisposing conditions such as alcoholism, chronic viral hepatitis, aflatoxin B1 ingestion, and cirrhosis all contribute
Shum David, Morettin Alan, Ward Alejandra, Hudson John W   +3 more
doaj   +1 more source

Genome‐wide CRISPR screen reveals an uncharacterized spliceosome regulator as new candidate immunotherapy target

iMeta, Volume 4, Issue 6, December 2025.
This study identifies the uncharacterized gene C9ORF50 as a novel regulator of immune evasion. Functioning as an intrinsically disordered protein, C9ORF50 drives liquid‐liquid phase separation to facilitate spliceosome assembly and maintain RNA splicing fidelity.
Tong Shao, Chuanyang Liu, Jingyu Kuang, Sisi Xie, Ying Qu, Yingying Li, Lulu Zhang, Fangzhou Liu, Yanhua Qi, Tao Hou, Ming Li, Sujuan Zhang, Yu Liu, Zhixiang Yuan, Jiali Liu, Yanming Hu, Jingyang Wang, Chenghu Song, Shaowei Zhang, Lingyun Zhu, Jianzhong Shao, Aifu Lin, Wenjun Mao, Guangchuan Wang, Lvyun Zhu   +24 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source