Results 71 to 80 of about 3,466 (159)

Prolonged overexpression of PLK4 leads to formation of centriole rosette clusters that are connected via canonical centrosome linker proteins

Scientific Reports
Centrosome amplification is a hallmark of cancer and PLK4 is one of the responsible factors for cancer associated centrosome amplification. Increased PLK4 levels was also shown to contribute to generation of cells with centriole amplification in ...
Selahattin Can Ozcan, Batuhan Mert Kalkan, Enes Cicek, Ata Alpay Canbaz, Ceyda Acilan   +4 more
doaj   +1 more source

Feedback loops in the Plk4–STIL–HsSAS6 network coordinate site selection for procentriole formation

Biology Open, 2019
Centrioles are duplicated once in every cell cycle, ensuring the bipolarity of the mitotic spindle. How the core components cooperate to achieve high fidelity in centriole duplication remains poorly understood. By live-cell imaging of endogenously tagged
Daisuke Takao, Koki Watanabe, Kanako Kuroki, Daiju Kitagawa   +3 more
doaj   +1 more source

Synthetic lethality of drug-induced polyploidy and BCL-2 inhibition in lymphoma

Nature Communications, 2023
Genomic instability occurs infrequently in in diffuse large B cell lymphoma (DLBCL), suggesting a therapeutic vulnerability. Here, the authors identify a synergistic combination between the induction of polyploidy by a PLK4 inhibitor and a BCL-2 ...
Ana Portelinha, Mariana da Silva Ferreira, Tatiana Erazo, Man Jiang, Zahra Asgari, Elisa de Stanchina, Anas Younes, Hans-Guido Wendel   +7 more
doaj   +1 more source

Functional relationship among PLK2, PLK4 and ROCK2 to induce centrosome amplification [PDF]

Cell Cycle, 2015
The presence of more than 2 centrosomes (centrosome amplification) leads to defective mitosis and chromosome segregation errors, is frequently found in a variety of cancer types, and believed to be the major cause of chromosome instability. One mechanism for generation of amplified centrosomes is over-duplication of centrosomes in a single cell cycle ...
Hongbo, Ling, Kazuhiko, Hanashiro, Tran H, Luong, Luis, Benavides, Kenji, Fukasawa   +4 more
openaire   +2 more sources

GSK461364 Inhibits NLRP3 Inflammasome by Targeting NEK7 Phosphorylation

Advanced Science, Volume 12, Issue 44, November 27, 2025.
Schematic diagram of the mechanism by which GSK461364 inhibits NLRP3 inflammasome activation. GSK461364 inhibits the phosphorylation of NEK7 likely at serine 221 and serine 260 by suppressing the activity of PLK1, thereby restraining the formation of the NLRP3 inflammasome.
Ruiheng Luo, Mingliang Ma, Dan Wang, Ling Luo, Xueming Xu, Lingmin Huang, Fupeng Wang, Guangyan Kuang, Huiqi Liu, Rui Ni, Xin Li, Qinghua Zhang, Shengfeng Wang, Kai Zhao   +13 more
wiley   +1 more source

Plk4 Phosphorylates Ana2 to Trigger Sas6 Recruitment and Procentriole Formation [PDF]

Current Biology, 2014
Centrioles are 9-fold symmetrical structures at the core of centrosomes and base of cilia whose dysfunction has been linked to a wide range of inherited diseases and cancer. Their duplication is regulated by a protein kinase of conserved structure, the C. elegans ZYG-1 or its Polo-like kinase 4 (Plk4) counterpart in other organisms.
Dzhindzhev, Nikola S., Tzolovsky, George, Lipinszki, Zoltan, Schneider, Sandra, Lattao, Ramona, Fu, Jingyan, Debski, Janusz, Dadlez, Michal, Glover, David M.   +8 more
openaire   +3 more sources

When the Clock Is Ticking: The Role of Mitotic Duration in Cell Fate Determination

BioEssays, Volume 47, Issue 11, November 2025.
Recently, several studies identified mechanisms by which cells measure mitotic duration and how this influences cell fate, leading to normal cell cycle progression or G1 arrest. In light of drug‐resistant cancer cells that continue proliferating even after mitotic errors, understanding these mechanisms opens the door for new potential therapeutic ...
Cornelia Sala, Elmar Schiebel
wiley   +1 more source

Self-organization of Plk4 regulates symmetry breaking in centriole duplication

Nature Communications, 2019
During centriole duplication, Plk4 regulates formation of a single daughter centriole adjacent to the mother centriole, but the mechanism is unclear. Here, the authors show that Plk4 can undergo liquid–liquid phase separation and that the condensation ...
Shohei Yamamoto, Daiju Kitagawa
doaj   +1 more source

Anticancer Potential of Wogonin: A Comprehensive Treatise

Food Science &Nutrition, Volume 13, Issue 11, November 2025.
Wogonin a plant flavonoid is abundantly found in the roots of Scutellaria baicalensis. In in vivo and in vitro investigations, it has immense therapeutic potential against different cancers including ovarian, colon, gastric, cervical, prostate, glioblastoma, head and neck cancer, hepatic cancer, leukemia, gastric, breast and kidney.
Hammad Naeem, Muhammad Shahbaz, Ushna Momal, Nimra Irshad, Muhammad Imran, Muzzamal Hussain, Tadesse Fenta Yehuala, Mohamed A. Abdelgawad, Ehab M. Mostafa, Mohammed M. Ghoneim, Samy Selim, Soad K. Al Jaouni, Suliman A. Alsagaby, Waleed Al Abdulmonem   +13 more
wiley   +1 more source

The RAC1 activator Tiam1 regulates centriole duplication through controlling PLK4 levels

Journal of Cell Science, 2020
SummaryCentriole duplication is tightly controlled to maintain correct centriole number through the cell cycle. A key component of this control is the regulated degradation of PLK4, the master regulator of centriole duplication. Here we show that the Rac1 guanine nucleotide exchange factor (GEF) Tiam1 localises to centrosomes during S-phase, where it ...
Andrew P. Porter, Hannah Reed, Gavin R. M. White, Erinn-Lee Ogg, Helen J. Whalley, Angeliki Malliri   +5 more
openaire   +3 more sources