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Frontiers in Cell and Developmental Biology, 2014 Vacanti and colleagues recently reported the generation of mouse cells exhibiting pluri/totipotency by stress treatment, and showed that these cells can give rise to chimeras and clonal adults (Obokata et al., 2014a,b). The findings were controversial, and the authors have now retracted the papers, citing multiple critical errors within the reports ...
Bor Luen eTang
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Assessing kidney development and disease using kidney organoids and CRISPR engineering
Frontiers in Cell and Developmental Biology, 2022 The differentiation of human pluripotent stem cells (hPSCs) towards organoids is one of the biggest scientific advances in regenerative medicine. Kidney organoids have not only laid the groundwork for various organ-like tissue systems but also provided ...
Wajima Safi +7 more
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Pluripotency of induced pluripotent stem cells [PDF]
Journal of Animal Science and Biotechnology, 2012 Recent studies have demonstrated that differentiated somatic cells from various mammalian species can be reprogrammed into induced pluripotent stem (iPS) cells by the ectopic expression of four transcription factors that are highly expressed in embryonic stem (ES) cells.
Kang Lan, Gao Shaorong
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Pluripotency Deconstructed [PDF]
Development, Growth & Differentiation, 2018 Pluripotency denotes the flexible capacity of single cells to give rise to all somatic lineages and typically also the germline. Mouse ES cells and post‐implantation epiblast‐derived stem cells (EpiSC) are widely used pluripotent cell culture systems. These two in vitro stem cell types have divergent characteristics.
Kinoshita, Masaki, Smith, Austin
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Recreating Pluripotency? [PDF]
Cell Stem Cell, 2010 Two Matters Arising articles in this issue challenge the conclusions of a previous Cell Stem Cell paper that found extensive transcriptional differences between hESCs and hiPSCs. The original authors provide a response and set in motion a discussion in the field about appropriate methods for microarray data analysis.
Loh, Kyle M., Lim, Bing
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Limited in vitro differentiation of porcine induced pluripotent stem cells into endothelial cells
Journal of Animal Reproduction and Biotechnology, 2023 Background: Pluripotent stem cells (PSCs) including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) offer the immense therapeutic potential in stem cell-based therapy of degenerative disorders.
In-Won Lee +8 more
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Cell, 2008 In this Essay, we argue that pluripotent epiblast founder cells in the embryo and embryonic stem (ES) cells in culture represent the ground state for a mammalian cell, signified by freedom from developmental specification or epigenetic restriction and capacity for autonomous self-replication.
Silva, Jose, Smith, Austin
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Hybridization led to a rewired pluripotency network in the allotetraploid Xenopus laevis
eLife, 2023 After fertilization, maternally contributed factors to the egg initiate the transition to pluripotency to give rise to embryonic stem cells, in large part by activating de novo transcription from the embryonic genome.
Wesley A Phelps +5 more
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Differential Expression Pattern of linc-ROR Spliced Variants in Pluripotent and Non-Pluripotent Cell Lines [PDF]
Cell Journal, 2022 Objective: The human large intergenic non-coding RNA-regulator of reprogramming program (linc-ROR) is known as astem cell specific linc-RNA. linc-ROR counteracts differentiation via sequestering microRNA-145 (miR-145) that targets OCT4 transcript ...
Fatemeh Mirzadeh Azad +8 more
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Cell Reports, 2020 Summary: Human naive pluripotent stem cells established from the epiblasts of preimplantation blastocysts provide a useful model for mechanistic studies of pluripotency regulation and lineage differentiation. Important advances have been made to optimize
Yan Bi +10 more
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