Results 11 to 20 of about 53,758 (224)

High-Throughput and Cost-Effective Characterization of Induced Pluripotent Stem Cells. [PDF]

, 2017
Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) offers the possibility of studying the molecular mechanisms underlying human diseases in cell types difficult to extract from living patients, such as neurons and cardiomyocytes.
Arias, Angelo, D'Antonio, Matteo, D'Antonio-Chronowska, Agnieszka, Frazer, Kelly A, Goldstein, Lawrence SB, Herrera, Cheryl, Matsui, Hiroko, Nathanson, Jason L, Panopoulos, Athanasia D, Reyna, Sol M, Williams, Roy, Woodruff, Grace, Yeo, Gene W   +12 more
core   +8 more sources

Global DNA hypomethylation prevents consolidation of differentiation programs and allows reversion to the embryonic stem cell state. [PDF]

, 2012
DNA methylation patterns change dynamically during mammalian development and lineage specification, yet scarce information is available about how DNA methylation affects gene expression profiles upon differentiation.
Bultmann, Sebastian, Leonhardt, Heinrich, Maier, Kerstin C., Martin, Dietmar E., Meilinger, Daniela, Peter, Christian, Schmidt, Christine S., Spada, Fabio, Tresch, Achim, Zacher, Benedikt   +9 more
core   +11 more sources

Phosphoproteomics identifies a bimodal EPHA2 receptor switch that promotes embryonic stem cell differentiation [PDF]

, 2020
Embryonic Stem Cell (ESC) differentiation requires complex cell signalling network dynamics, although the key molecular events remain poorly understood.
Budzyk, Manon, Bustos, Francisco, Fernandez-Alonso, Rosalia, Findlay, Greg M., Helbig, Andreas O., Hukelmann, Jens, Kumar, Pankaj, Lamond, Angus I., Lanner, Fredrik, Petsalaki, Evangelia, Zhou, Houjiang   +10 more
core   +2 more sources

Pressure-induced changes on the morphology and gene expression in mammalian cells

Biology Open, 2021
We evaluated the effect of high hydrostatic pressure on mouse embryonic fibroblasts (MEFs) and mouse embryonic stem (ES) cells. Hydrostatic pressures of 15, 30, 60, and 90 MPa were applied for 10 min, and changes in gene expression were evaluated.
Kazuko Okamoto, Tomonobu M. Watanabe, Masanobu Horie, Masayoshi Nishiyama, Yoshie Harada, Hideaki Fujita   +5 more
doaj   +1 more source

Neural induction drives body axis formation during embryogenesis, but a neural induction-like process drives tumorigenesis in postnatal animals

Frontiers in Cell and Developmental Biology, 2023
Characterization of cancer cells and neural stem cells indicates that tumorigenicity and pluripotency are coupled cell properties determined by neural stemness, and tumorigenesis represents a process of progressive loss of original cell identity and gain
Ying Cao, Ying Cao, Ying Cao
doaj   +1 more source

Pluripotential Risk and Clinical Staging: Theoretical Considerations and Preliminary Data From a Transdiagnostic Risk Identification Approach

Frontiers in Psychiatry, 2021
Most psychiatric disorders develop during adolescence and young adulthood and are preceded by a phase during which attenuated or episodic symptoms and functional decline are apparent. The introduction of the ultra-high risk (UHR) criteria two decades ago
Jessica A. Hartmann, Jessica A. Hartmann, Patrick D. McGorry, Patrick D. McGorry, Louise Destree, G. Paul Amminger, G. Paul Amminger, Andrew M. Chanen, Andrew M. Chanen, Christopher G. Davey, Christopher G. Davey, Christopher G. Davey, Rachid Ghieh, Rachid Ghieh, Andrea Polari, Andrea Polari, Aswin Ratheesh, Aswin Ratheesh, Hok Pan Yuen, Hok Pan Yuen, Barnaby Nelson, Barnaby Nelson   +21 more
doaj   +1 more source

Human Amniocytes Are Receptive to Chemically Induced Reprogramming to Pluripotency [PDF]

, 2017
Restoring pluripotency using chemical compounds alone would be a major step forward in developing clinical-grade pluripotent stem cells, but this has not yet been reported in human cells.
Adjaye, J, Campanella, M, De Coppi, P, Eaton, S, Faccenda, D, Guillot, P V, Hau, K-L, Hawkins, K E, Martin-Trujillo, A, Monk, D, Moschidou, D, Ranzoni, A M, Sanchez-Freire, V, Thrasher, A J, Tommasini, F, Wruck, W   +15 more
core   +4 more sources

Generation and cardiac subtype-specific differentiation of PITX2-deficient human iPS cell lines for exploring familial atrial fibrillation

Stem Cell Research, 2017
Loss-of-function mutations in the PITX2 transcription factor gene have been shown to cause familial atrial fibrillation (AF). To potentially model aspects of AF and unravel PITX2-regulated downstream genes for drug target discovery, we here report the ...
Maike Marczenke, Jakob Fell, Ilaria Piccini, Albrecht Röpke, Guiscard Seebohm, Boris Greber   +5 more
doaj   +1 more source

Effect of low oxygen tension on transcriptional factor OCT4 and SOX2 expression in New Zealand rabbit bone marrow-derived mesenchymal stem cells [PDF]

Veterinary World, 2020
Background and Aim: Octamer-binding transcription factor 4 (OCT4) and sex-determining region Y-box 2 (SOX2) are transcription factors whose functions are essential to maintain the pluripotency of embryonic stem cells.
Erma Safitri
doaj   +1 more source

NaNog: A pluripotency homeobox (master) molecule. [PDF]

, 2015
One of the most intriguing aspects of cell biology is the state of pluripotency, where the cell is capable of self-renewal for as many times as deemed necessary , then at a specified time can differentiate into any type of cell. This fundamental process
Aguib, YE, Allouba, MH, ElGuindy, AM, Krishnamoorthy, N, Yacoub, MH   +4 more
core   +1 more source