Results 31 to 40 of about 53,758 (224)

Pluripotency of Induced Pluripotent Stem Cells

Genomics, Proteomics & Bioinformatics, 2013
Abstract Induced pluripotent stem (iPS) cells can be generated by forced expression of four pluripotency factors in somatic cells. This has received much attention in recent years since it may offer us a promising donor cell source for cell transplantation therapy. There has been great progress in iPS cell research in the past few years.
Feng, Chunjing, Jia, Yun-Dan, Zhao, Xiao-Yang   +2 more
openaire   +2 more sources

UPS Delivers Pluripotency [PDF]

Cell Stem Cell, 2012
In this issue of Cell Stem Cell, Buckley et al. (2012) show that the ubiquitin-proteasome system (UPS) regulates pluripotency in embryonic stem cells and induced pluripotent stem cells, opening the door to a better understanding at the system level of protein dynamics responsible for the maintenance and induction of pluripotency.
Okita, Yasutaka, Nakayama, Keiichi I.
openaire   +2 more sources

The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis [PDF]

, 2019
Post-transcriptional mechanisms have the potential to influence complex changes in gene expression, yet their role in cell fate transitions remains largely unexplored.
Aigner, S., Anselmo, A., Brumbaugh, J., Charlton, J., Clement, K., Clowers, K., de Kort, M., Di Stefano, B., Gerli, M., Gu, H., Gygi, S., Haggerty, C., Hochedlinger, K., Huebner, A., Ji, F., Lipchina, I., Luo, E., Meissner, A., Pulice, J., Rabano Jiménez, I., Sadreyev, R., Yeo, G.   +21 more
core   +3 more sources

Construction of recombinant sox2-encoding plasmids that regulate pluripotency of breast cancer stem cells from indonesian patient [PDF]

Pharmaciana, 2019
A therapy development with recombinant protein is a new and potential innovation to destroy cancer stem cells (CSCs). Various ways of killing CSCs include the provision of polyvalent anti-protein antibodies that code pluripotency.
Hanifah Rahmi, Tiodinar Theresia, Amarila Malik, Septelia Inawati Wanandi   +3 more
doaj   +1 more source

“TET-on” pluripotency [PDF]

Cell Research, 2013
Recent studies have uncovered a specific role of TET proteins in reprogramming somatic cells to induced pluripotent stem cells, a process where O-linked β-N-acetylglucosamine transferase may play a crucial role.
Ping, Wang, Jing, Qu, Min-Zu, Wu, Weizhou, Zhang, Guang-Hui, Liu, Juan Carlos, Izpisua Belmonte   +5 more
openaire   +2 more sources

Co-expression networks in generation of induced pluripotent stem cells. [PDF]

, 2016
We developed an adenoviral vector, in which Yamanaka's four reprogramming factors (RFs) were controlled by individual CMV promoters in a single cassette (Ad-SOcMK). This permitted coordinated expression of RFs (SOX2, OCT3/4, c-MYC and KLF4) in a cell for
Coppola, Giovanni, Dansithong, Warunee, Figueroa, Karla P, Gao, Fuying, Paul, Sharan, Pflieger, Lance, Pulst, Stefan M   +6 more
core   +2 more sources

Generation of induced pluripotent stem cell line, CSSi004-A (2962), from a patient diagnosed with Huntington's disease at the presymptomatic stage [PDF]

, 2018
Huntington's disease (HD) is an incurable, autosomal dominant, hereditary neurodegenerative disorder that typically manifests itself in midlife. This pathology is linked to the deregulation of multiple, as yet unknown, cellular processes starting before ...
Bernardini, Laura, Bidollari, Eris, Candido, Ornella, Consoli, Federica, De Luca, Alessandro, Ferrari, Daniela, Ilari, Andrea, Lamorte, Giuseppe, Rosati, Jessica, Rotundo, Giovannina, Santimone, Iolanda, Squitieri, Ferdinando, Vescovi, Angelo Luigi   +12 more
core   +9 more sources

NANOG expression in parthenogenetic porcine blastocysts is required for intact lineage specification and pluripotency [PDF]

Animal Bioscience, 2023
Objective Nanog homeobox (NANOG) is a core transcription factor that contributes to pluripotency along with octamer binding transcription factor-4 (OCT4) and sex determining region-Y box-2 (SOX2).
Mingyun Lee, Jong-Nam Oh, Gyung Cheol Choe, Kwang-Hwan Choi, Dong-Kyung Lee, Seung-Hun Kim, Jinsol Jeong, Yelim Ahn, Chang-Kyu Lee   +8 more
doaj   +1 more source

Defining Human Pluripotency [PDF]

Cell Stem Cell, 2019
Human pluripotent stem cells harbor the capacity to differentiate into cells from the three embryonic germ layers, and this ability grants them a central role in modeling human disorders and in the field of regenerative medicine. Here, we review pluripotency in human cells with respect to four different aspects: (1) embryonic development, (2 ...
Atilgan, Yilmaz, Nissim, Benvenisty
openaire   +2 more sources

Metamachines of pluripotent colloids [PDF]

Nature Communications, 2021
AbstractMachines enabled the Industrial Revolution and are central to modern technological progress: A machine’s parts transmit forces, motion, and energy to one another in a predetermined manner. Today’s engineering frontier, building artificial micromachines that emulate the biological machinery of living organisms, requires faithful assembly and ...
Antoine Aubret, Quentin Martinet, Jeremie Palacci   +2 more
openaire   +6 more sources