Results 51 to 60 of about 53,758 (224)

Generation of a human iPS cell line from a patient with retinitis pigmentosa due to EYS mutation [PDF]

, 2018
Retinitis pigmentosa (RP) is an inherited retinal degenerative disease. Mutations in EYS have been associated with autosomal recessive RP. The human iPS cell line, CABi002-A, derived from peripheral blood mononuclear cells from a patient carrying a ...
Bhattacharya, Shomi S., Calado, Sofía M., Cerda, Berta De la, Díaz Corrales, Francisco Javier, García Delgado, Ana Belén, Ponte-Zuñiga, Beatriz   +5 more
core   +1 more source

BCMA (TNFRSF17) Induces APRIL and BAFF Mediated Breast Cancer Cell Stemness

Frontiers in Oncology, 2018
Recent advances in cancer immunology revealed immune-related properties of cancer cells as novel promising therapeutic targets. The two TNF superfamily members, APRIL (TNFSF13), and BAFF (TNFSF13B), which are type II membrane proteins, released in active
Vasiliki Pelekanou, George Notas, Paraskevi Athanasouli, Konstantinos Alexakis, Fotini Kiagiadaki, Nikolaos Peroulis, Konstantina Kalyvianaki, Errika Kampouri, Hara Polioudaki, Panayiotis Theodoropoulos, Andreas Tsapis, Elias Castanas, Marilena Kampa   +12 more
doaj   +1 more source

Direct comparison of distinct naive pluripotent states in human embryonic stem cells [PDF]

, 2017
Until recently, human embryonic stem cells (hESCs) were shown to exist in a state of primed pluripotency, while mouse embryonic stem cells (mESCs) display a naive or primed pluripotent state.
Chuva de Sousa Lopes, Susana Marina, De Coninck, Dieter, De Sutter, Petra, Deforce, Dieter, Duggal, Galbha, Heindryckx, Björn, Lierman, Sylvie, Menten, Björn, Mestdagh, Pieter, Peelman, Luc, Popovic, Mina, Sutherland, Ella, Taelman, Jasin, Tilleman, Laurentijn, Van der Jeught, Margot, Van Nieuwerburgh, Filip, Van Soom, Ann, Vandesompele, Jo, Warrier, Sharat   +18 more
core   +1 more source

Repressing Ago2 mRNA translation by Trim71 maintains pluripotency through inhibiting let-7 microRNAs

eLife, 2021
The regulation of stem cell fate is poorly understood. Genetic studies in Caenorhabditis elegans lead to the hypothesis that a conserved cytoplasmic double-negative feedback loop consisting of the RNA-binding protein Trim71 and the let-7 microRNA ...
Qiuying Liu, Xiaoli Chen, Mariah K Novak, Shaojie Zhang, Wenqian Hu   +4 more
doaj   +1 more source

Interactome comparison of human embryonic stem cell lines with the inner cell mass and trophectoderm [PDF]

, 2018
Networks of interacting co-regulated genes distinguish the inner cell mass (ICM) from the differentiated trophectoderm (TE) in the preimplantation blastocyst, in a species specific manner.
Bates, Nicola, Brison, Daniel R., Garner, Terence, Kimber, Susan J., Minogue, Ben, Oldershaw, Rachel, Shaw, Lisa, Smith, Helen, Sneddon, Sharon, Stevens, Adam   +9 more
core   +1 more source

Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells

eLife, 2022
The transcription factor Oct4 is essential for the maintenance and induction of stem cell pluripotency, but its functional roles are not fully understood.
Le Xiong, Erik A Tolen, Jinmi Choi, Sergiy Velychko, Livia Caizzi, Taras Velychko, Kenjiro Adachi, Caitlin M MacCarthy, Michael Lidschreiber, Patrick Cramer, Hans R Schöler   +10 more
doaj   +1 more source

Connecting the DOTs on Cell Identity

Frontiers in Cell and Developmental Biology, 2022
DOT1-Like (DOT1L) is the sole methyltransferase of histone H3K79, a modification enriched mainly on the bodies of actively transcribing genes. DOT1L has been extensively studied in leukemia were some of the most frequent onco-fusion proteins contain ...
Coral K. Wille, Rupa Sridharan, Rupa Sridharan   +2 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Postembryonic organogenesis and plant regeneration from tissues:two sides of the same coin?

Frontiers in Plant Science, 2014
Plants have extraordinary developmental plasticity as they continuously form organs duringpostembryonic development. In addition they may regenerate organs upon in vitro hormonalinduction.
Juan ePerianez-Rodriguez, Concepcion eManzano, Miguel Angel Moreno-Risueno   +2 more
doaj   +1 more source

The thyroid hormone enhances mouse embryonic fibroblasts reprogramming to pluripotent stem cells: role of the nuclear receptor corepressor 1

Frontiers in Endocrinology, 2023
IntroductionPluripotent stem cells can be generated from somatic cells by the Yamanaka factors Oct4, Sox2, Klf4 and c-Myc.MethodsMouse embryonic fibroblasts (MEFs) were transduced with the Yamanaka factors and generation of induced pluripotent stem cells
Constanza Contreras-Jurado, Constanza Contreras-Jurado, Constanza Contreras-Jurado, Ana Montero-Pedrazuela, Raúl F. Pérez, Raúl F. Pérez, Raúl F. Pérez, Raúl F. Pérez, Raúl F. Pérez, Susana Alemany, Mario F. Fraga, Mario F. Fraga, Mario F. Fraga, Mario F. Fraga, Mario F. Fraga, Ana Aranda, Ana Aranda   +16 more
doaj   +1 more source