Results 81 to 90 of about 53,758 (224)
Capturing bovine pluripotency [PDF]
Proceedings of the National Academy of Sciences, 2018 Mouse embryonic stem cells (ESC) were successfully isolated and characterized in the early 1980s (1, 2), followed by the establishment of ESC from primates more than a decade later (3). However, despite continuous efforts since then, the establishment of ESC lines from domesticated species has remained elusive. Over the years, there have been numerous,
openaire +2 more sources
Pluripotency in 3D: genome organization in pluripotent cells [PDF]
Current Opinion in Cell Biology, 2012 Cells face the challenge of storing two meters of DNA in the three-dimensional (3D) space of the nucleus that spans only a few microns. The nuclear organization that is required to overcome this challenge must allow for the accessibility of the gene regulatory machinery to the DNA and, in the case of embryonic stem cells (ESCs), for the transcriptional
Matthew, Denholtz, Kathrin, Plath
openaire +2 more sources
, 2020 X‐chromosome inactivation ensures dosage compensation between the sexes in mammals by randomly choosing one out of the two X chromosomes in females for inactivation.
Barr M. L. +4 more
core +1 more source
Advanced Science, EarlyView.This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang +11 more
wiley +1 more source
Advanced SciencePorcine embryonic stem cells (ESCs) are excellent models for exploring embryogenesis, producing genetically enhanced farm animals, and improving breeding.
Hanning Wang +4 more
doaj +1 more source
Epigenetics of Pluripotent Cells [PDF]
Acta Naturae, 2012 Pluripotency is maintained by a complex system that includes the genetic and epigenetic levels. Recent studies have shown that the genetic level (transcription factors, signal pathways, and microRNAs) closely interacts with the enzymes and other specific proteins that participate in the formation of the chromatin structure.
Medvedev, S., Pokushalov, E., Zakian, S.
openaire +3 more sources
Advanced Science, EarlyView.Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian +5 more
wiley +1 more source
Non-coding RNAs in pluripotency and neural differentiation of human pluripotent stem cells
Frontiers in Genetics, 2014 Several studies have demonstrated the important role of non-coding RNAs as regulators of posttranscriptional processes, including stem cells self-renewal and neural differentiation.
Dunja eLukovic +6 more
doaj +1 more source
Statistical Mechanics of Pluripotency [PDF]
Cell, 2013 Recent reports using single-cell profiling have indicated a remarkably dynamic view of pluripotent stem cell identity. Here, we argue that the pluripotent state is not well defined at the single-cell level but rather is a statistical property of stem cell populations, amenable to analysis using the tools of statistical mechanics and information theory.
MacArthur, Ben D., Lemischka, Ihor R.
openaire +3 more sources
Advanced Science, EarlyView.This study presents a 3D lymphoid tissue model engineered from adipose‐derived stem cells differentiated into fibroblastic reticular cell–like networks and co‐cultured with immune cells. The engineered system successfully generates antigen‐specific antibodies and cytokine responses, providing a platform for studying adaptive immunity, vaccine efficacy,
Mei ElGindi, Shaza Karaman, Jeremy Teo
wiley +1 more source