Results 91 to 100 of about 46,902 (263)

PML: Regulation and multifaceted function beyond tumor suppression

Cell & Bioscience, 2018
Promyelocytic leukemia protein (PML) was originally identified as a fusion partner of retinoic acid receptor alpha in acute promyelocytic leukemia patients with the (15;17) chromosomal translocation, giving rise to PML–RARα and RARα–PML fusion proteins ...
Kuo-Sheng Hsu, Hung-Ying Kao
doaj   +1 more source

Covert Optical Fingerprints Within Overt Structural Colors via Cascaded Cavity Resonances

Advanced Science, EarlyView.
Cascaded photonic–plasmonic cavities combine vivid structural colors with hidden stochastic optical fingerprints in a single monolithic platform. Layered cavities control the overt appearance, while disordered nanogap resonances generate covert scattering with limited mutual influence.
Gyurin Kim, Jiyeong Ma, Juhwan Kim, JuHyeong Lee, Heungchan Kwon, Young Min Song, Hyeon‐Ho Jeong   +6 more
wiley   +1 more source

Circadian behavior of mice deficient in PER1/PML or PER2/PML

Journal of Circadian Rhythms, 2013
Our recent studies demonstrate that the murine homolog of the human tumor suppressor promyelocytic leukemia (PML) regulates circadian behavior of mice. To further gather insight into PML's contribution to circadian behavior, we generated two strains of mice deficient in one of the two period (Per) genes and the PML gene, with Per1-/-/Pml-/- and Per2-/-/
Miki, Takao, Chen-Goodspeed, Misty, Zhao, Zhaoyang, Lee, Cheng Chi   +3 more
openaire   +5 more sources

A Comprehensive Comparative Study of Active Learning Schemes for Nanophotonics Design

Advanced Intelligent Discovery, EarlyView.
Active learning (AL) strategies are benchmarked for the binary design of planar multilayer nanophotonic structures. Factorization machines combined with quantum annealing (QA) become effective as dimensionality increases. Hybrid QA provides the strongest results for 100‐layer problems, highlighting the importance of optimization method selection in ...
Serang Jung, Seongmin Kim, Jaehyun Park, Chaeyoung Park, Zhihao Xu, Sanghyo Hwang, Baiqing Ye, Youn sang Kim, Sun‐Kyung Kim, Tengfei Luo, Eungkyu Lee   +10 more
wiley   +1 more source

Magnesium hydroxide addition reduces aqueous carbon dioxide in wastewater discharged to the ocean

Communications Earth & Environment
Ocean alkalinity enhancement (OAE) reduces the concentration of dissolved carbon dioxide (CO2) in seawater, leading to atmospheric carbon dioxide removal (CDR).
Vassilis Kitidis, Stephen. A. Rackley, William. J. Burt, Greg. H. Rau, Samuel Fawcett, Matthew. Taylor, Glen Tarran, E. Malcolm S. Woodward, Carolyn Harris, Timothy Fileman   +9 more
doaj   +1 more source

Regulation of the tumor suppressor PML by sequential posttranslational modifications

Frontiers in Oncology, 2012
Posttranslational modifications (PTMs) regulate multiple biological functions of the PML (promyelocytic leukemia) protein and also the fission, disassembly and rebuilding of PML nuclear bodies (PML-NBs) during the cell cycle.
Lienhard eSchmitz, Inna eGrishina
doaj   +1 more source

Selective Activation of Nfat by Promyelocytic Leukemia Protein

, 2009
Promyelocytic leukemia (PML) protein is a tumor suppressor with complicated action mechanisms not yet fully understood. In this study, we found that the nuclear factor of activated T cell ( NFAT) is an unexpected partner of PML: PML specifically enhanced
駱育壎;施修明;賴明宗, LO, YU-HSUN;SHIH, HSIU-MING;LAI, MING- ZONG   +1 more
core   +1 more source

Benchmarking Data‐Driven Control of Octopus‐Inspired Soft Arms in Underwater Environment

Advanced Intelligent Systems, EarlyView.
Underwater soft robots present safe, compliant interaction, yet reproducible control remains scarce. This work presents an open benchmark for octopus‐inspired arms: a smooth, velocity‐diverse data‐collection scheme produces a compact dataset to train a vanilla policy.
Muhammad Sunny Nazeer, Yasmin Tauqeer Ansari, Emanuele Solfiti, Baljinder Singh Bal, Matteo Lo Preti, Barbara Mazzolai, Cecilia Laschi   +6 more
wiley   +1 more source

The role of PML proteins in adenovirus type 5 infection and the type I interferon response [PDF]

Promyelocytic leukaemia (PML) proteins consist of a collection of related isoforms that are the nucleating components of sub-nuclear structures termed PML nuclear bodies (PML NBs). Numerous functions are attributed to PML and PML NBs, including a role
Wright, Jordan
core  

PML inhibits HCMV gene transcription.

, 2023
PML knockout (PML-KO), PML overexpressing (PML-OE), and their controls (Ctl and NC, respectively) cells were infected with HCMV Towne strain at an MOI of 5 and collected at the indicated times for viral gene transcription quantification.
Fei Hu (191861), Simon Rayner (117650), Yong Qiu (83780), Fang-Cheng Li (3384743), Shuang Cheng (610515), Han Cheng (475615), Le Wen (14587872), Xian-Zhang Wang (11680805), Jin-Yan Sun (11930542), Jian Chen (15340), William J. Britt (15295121), Yue-Peng Zhou (5337254), Qing-Yang Zhang (1401712), Xing-Jun Jiang (15295118), Min-Hua Luo (522503)   +14 more
core   +1 more source