Results 81 to 90 of about 42,451 (299)

Regulation of the tumor suppressor PML by sequential posttranslational modifications

Frontiers in Oncology, 2012
Posttranslational modifications (PTMs) regulate multiple biological functions of the PML (promyelocytic leukemia) protein and also the fission, disassembly and rebuilding of PML nuclear bodies (PML-NBs) during the cell cycle.
Lienhard eSchmitz, Inna eGrishina
doaj   +1 more source

Relationship between FLT3 mutation status, biologic characteristics, and response to targeted therapy in acute promyelocytic leukemia

, 2005
The prognostic significance of FLT3 mutations in acute promyelocytic leukemia (APL) is not firmly established and is of particular interest given the opportunities for targeted therapies using FLT3 inhibitors.
Gilkes, Amanda F., Ellen Solomon, Linch, D C, Gale, Rosmary E., Burnett, Alan Kenneth, Gale, RE, David C. Linch, Pizzey, AR, Elizabeth Nugent, Keith Wheatley, Grimwade, D., Grimwade, D, Solomon, E, Pizzey, A R, Solomon, Ellen, Kenneth I. Mills, Swirsky, D, Pizzey, A.R., Burnett, A K, Alan K. Burnett, Hills, Robert Kerrin, Swirsky, David, Kottaridis, Panagiotis D., Grimwade, David, Linch, David C., ?, ?, Hills, R., David Swirsky, Gale, R E, Gilkes, A F, Kottaridis, PD, Solomon, E., Robert Hills, Linch, D.C., Arnold R. Pizzey, Nugent, E., Rosemary E. Gale, Mills, KI, Nugent, Elizabeth, Gale, R.E., Swirsky, D., Hills, Robert, Hills, R, NCRI Adult Leukaemia Working Party, David Grimwade, Kottaridis, P D, Linch, DC, Wheatley, K., Amanda F. Gilkes, Wheatley, Keith, Gilkes, AF, Nugent, E, Panagiotis D. Kottaridis, Mills, K I, Mills, Ken; id_orcid, Kottaridis, P.D., Burnett, AK, Burnett, A.K., Mills, Kenneth I., Gilkes, A.F., Wheatley, K, Pizzey, Arnold R.   +61 more
core   +1 more source

Programmable Elastic Wave Control Via Mechanical‐Acoustic Interaction in Bistable Metamaterials

Advanced Science, EarlyView.
A mechanically programmable metamaterial based on mechanical‐acoustic interaction enables reconfigurable elastic wave control through bistable state switching. Spatial encoding of peak and valley states tunes band structures and transmission, achieving low‐frequency vibration suppression, waveguiding, and energy localization.
Yuanyuan Li, Yonghua Yu, Chuanqing Chen, Rui Xu, Yulong He, Xin Li, Ming‐Hui Lu, Yan‐Feng Chen   +7 more
wiley   +1 more source

Magnesium hydroxide addition reduces aqueous carbon dioxide in wastewater discharged to the ocean

Communications Earth & Environment
Ocean alkalinity enhancement (OAE) reduces the concentration of dissolved carbon dioxide (CO2) in seawater, leading to atmospheric carbon dioxide removal (CDR).
Vassilis Kitidis, Stephen. A. Rackley, William. J. Burt, Greg. H. Rau, Samuel Fawcett, Matthew. Taylor, Glen Tarran, E. Malcolm S. Woodward, Carolyn Harris, Timothy Fileman   +9 more
doaj   +1 more source

Expression and function of PML-RARA in the hematopoietic progenitor cells of Ctsg-PML-RARA mice. [PDF]

PLoS ONE, 2012
Because PML-RARA-induced acute promyelocytic leukemia (APL) is a morphologically differentiated leukemia, many groups have speculated about whether its leukemic cell of origin is a committed myeloid precursor (e.g. a promyelocyte) versus an hematopoietic
Lukas D Wartman, John S Welch, Geoffrey L Uy, Jeffery M Klco, Tamara Lamprecht, Nobish Varghese, Rakesh Nagarajan, Timothy J Ley   +7 more
doaj   +1 more source

The molecular evolution of DEDDh exonucleases reveals novel functions in innate immune signalling

, 2023
The Promyelocytic Leukemia (PML) protein is the major constituent of PML nuclear bodies (NBs), a subnuclear compartment involved in regulating a diverse array of cellular processes.
Mathavarajah, Sabateeshan
core  

CauFinder: Steering Cell‐State and Phenotype Transitions by Causal Disentanglement Learning

Advanced Science, EarlyView.
CauFinder combines causal disentanglement modeling and network control to prioritize causal drivers of cell‐state transitions from observational transcriptomic data. The framework separates transition‐relevant signals from spurious associations, nominates intervention targets across biological and disease contexts, and identifies DAAM1 as an actionable
Chengming Zhang, Zexi Chen, Yuanxiang Miao, Zuolin Shen, Deyu Cai, Shijie Tang, Yun Xue, Weifeng Guo, Hongbin Ji, Jian Liu, Kazuyuki Aihara, Luonan Chen   +11 more
wiley   +1 more source

Circadian behavior of mice deficient in PER1/PML or PER2/PML

Journal of Circadian Rhythms, 2013
Our recent studies demonstrate that the murine homolog of the human tumor suppressor promyelocytic leukemia (PML) regulates circadian behavior of mice. To further gather insight into PML's contribution to circadian behavior, we generated two strains of mice deficient in one of the two period (Per) genes and the PML gene, with Per1-/-/Pml-/- and Per2-/-/
Miki, Takao, Chen-Goodspeed, Misty, Zhao, Zhaoyang, Lee, Cheng Chi   +3 more
openaire   +5 more sources

Análise dos polimorfismos dos transcritos da translocação T(15;17)(Q22;Q21) na leucemia promielocítica aguda [PDF]

, 2013
TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.As leucemias agudas (LAs) constituem um grupo de neoplasias malignas caracterizado pela proliferação descontrolada de células hematopoiéticas na medula óssea
Silveira, Amanda da Silva
core  

Ultrasonic Rainbow: A Meta‐Transducer for Frequency‐Selective Elastic Wave Control via Dithering‐Based Wavenumber Tuning

Advanced Intelligent Systems, EarlyView.
A piezoelectric meta‐transducer generates an ultrasonic rainbow, steering guided elastic waves to different angles according to frequency. A dithering‐based binary electrode design enables a closer realization of the target wavenumber filter, improving directional purity and suppressing unwanted lobes. Numerical and experimental validation demonstrates
Masoud Mohammadgholiha, Jochen Moll, Kilian Tschöke, Carsten Kruska, Sylvia E. Gebhardt, Luca De Marchi   +5 more
wiley   +1 more source