Results 101 to 110 of about 42,451 (299)
Frontiers in Neurology, 2017 BackgroundProgressive multifocal leukoencephalopathy (PML) is a severe complication of immunosuppressive therapies, especially of natalizumab in relapsing–remitting multiple sclerosis (MS). Metabolic changes within PML lesions have not yet been described
Ruth Schneider +5 more
doaj +1 more source
Arthritis &Rheumatology, Accepted Article.Background Microbial small RNAs (sRNAs) can regulate human genes. Higher plasma concentrations of microbial tRNA‐derived RNA‐1 (tDR‐1) were previously associated with lower rheumatoid arthritis (RA) disease activity. This study examined whether tDR‐1 concentrations differ in anti‐cyclic citrullinated peptide‐3 positive (CCP3+) at‐risk individuals (ARI)
Anastasiia Phothisane +11 more
wiley +1 more source
TRIM19/PML Restricts HIV Infection in a Cell Type-Dependent Manner
Viruses, 2015 The promyelocytic leukemia protein (PML) is the main structural component of the nuclear matrix structures termed nuclear domain 10 (ND10) or PML nuclear bodies (PML-NBs).
Tanja Kahle +9 more
doaj +1 more source
PLoS Pathogens, 2020 Promyelocytic leukemia (PML) bodies are nuclear organelles implicated in intrinsic and innate antiviral defense. The eponymous PML proteins, central to the self-organization of PML bodies, and other restriction factors found in these organelles are ...
Christina Paulus +6 more
doaj +1 more source
Cleveland Clinic Journal of Medicine, 2011 The symptoms associated with progressive multifocal leukoencephalopathy (PML) reflect the location of pathologic brain lesions. These symptoms include visual deficits, cognitive impairment, and motor weakness; in patients with acquired immunodeficiency syndrome (AIDS), presenting signs can also include gait disturbance, dysarthria, dysphasia, and ...
openaire +2 more sources
DNA-binding defective PML/RARA mutants disrupt PML nuclear bodies.
, 2014 NIH-3T3 cells (A and C) or mouse HPCs (B and D) were infected with retroviral constructs expressing wild type or the indicated mutant PML/RARA respectively.
Laurent Peres (614585) +7 more
core +1 more source
The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome
Biological Reviews, EarlyView.ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke +2 more
wiley +1 more source
Cytoskeleton, EarlyView.ABSTRACT Microtubules play essential roles in numerous cellular processes. All microtubules are built from the protein tubulin, yet individual microtubules can differ spatially and temporally due to their tubulin isotype composition and post‐translational modifications (PTMs).
Ezekiel C. Thomas +5 more
wiley +1 more source
International Journal of Eating Disorders, EarlyView.ABSTRACT Objective Recent growth of online research has been accompanied by an increase in reports of fraudulent participants, which can significantly comprise research validity. Drawing from our experience using Qualtrics with open recruitment, existing literature, and emerging studies in eating disorders (ED), we outline the risk and provide simple ...
Jamie‐Lee Pennesi +2 more
wiley +1 more source
, 2011 Loss of the promyelocytic leukemia (PML) protein is associated with genomic instability/cancer. There are several isoforms of the PML protein that localize in PML nuclear bodies (PML NBs).
Tse, Brenda
core