Results 101 to 110 of about 46,902 (263)

The internal crest anatomy of Lambeosaurini (Hadrosauridae: Lambeosaurinae)

The Anatomical Record, EarlyView.
Abstract The supracranial crests of lambeosaurine hadrosaurids have long been a focus of study due primarily to their extreme morphology. The external anatomy of lambeosaurine crests is understood to be highly variable between species, but variation in their internal anatomy is less well understood.
Thomas W. Dudgeon, Courtney Brown, David C. Evans   +2 more
wiley   +1 more source

Anatomic and Histologic Analyses of the Popliteal Hiatus Area of the Lateral Meniscus Reveal the Meniscofibular Ligament and the Posteroinferior Popliteomeniscal Fascicle Are Ligamentous Tissue

Arthroscopy, EarlyView.
Purpose To characterize the anatomical structure and histological composition of connective tissue around the popliteal hiatus of the lateral meniscus (LM): the posterosuperior popliteomeniscal fascicle (PS‐PMF), posteroinferior popliteomeniscal fascicle (PI‐PMF), and anterior popliteomeniscal fascicle (A‐PMF), meniscofibular ligament (MFL), and ...
Heng Zhu, Su Yan, Pengcheng Tu, Xiaozhong Ma, Yunchen Wang, Hao Shu, Luning Sun   +6 more
wiley   +1 more source

Análise dos polimorfismos dos transcritos da translocação T(15;17)(Q22;Q21) na leucemia promielocítica aguda [PDF]

, 2013
TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.As leucemias agudas (LAs) constituem um grupo de neoplasias malignas caracterizado pela proliferação descontrolada de células hematopoiéticas na medula óssea
Silveira, Amanda da Silva
core  

The molecular evolution of DEDDh exonucleases reveals novel functions in innate immune signalling

, 2023
The Promyelocytic Leukemia (PML) protein is the major constituent of PML nuclear bodies (NBs), a subnuclear compartment involved in regulating a diverse array of cellular processes.
Mathavarajah, Sabateeshan
core  

Increased Plasma Microbial tDR‐1 in At‐Risk Individuals Is Associated With Decreased Conversion to Clinical Rheumatoid Arthritis and Reduces an In Vitro Macrophage Type 1 Interferon Response

Arthritis &Rheumatology, EarlyView.
Objective Microbial small RNAs can regulate human genes. Higher plasma concentrations of microbial transfer RNA (tRNA)‐derived RNA‐1 (tDR‐1) were previously associated with lower rheumatoid arthritis (RA) disease activity. This study examined whether tDR‐1 concentrations differ in anticyclic citrullinated peptide‐3 positive (CCP3+) at‐risk individuals (
Anastasiia Phothisane, Tulsi K. Joishy, Carolina Ramirez‐Becerra, Qiong Wu, Jennifer Seifert, Marie L. Feser, Jill M. Norris, M. Kristen Demoruelle, LauraKay Moss, Kevin D. Deane, V. Michael Holers, Michelle J. Ormseth   +11 more
wiley   +1 more source

Towards appropriate guidance for the ethical challenges of environmentally sustainable prescribing

British Journal of Clinical Pharmacology, EarlyView.
The environmental impact of medicines poses a significant threat to planetary and public health, making it essential to integrate environmental sustainability into prescribing practices. While the most effective measures to reduce environmental impact, such as reducing unnecessary prescriptions and medication waste, are consistent with appropriate ...
Joost D. Piët, Steven R. Kraaijeveld, Erik M. Donker, Milan C. Richir, Caroline T. A. Moermond, Amy Booth, SanYuMay Tun, Thijs H. Oude Munnink, Patricia M. L. A. van den Bemt, Lorena Dima, Ben J. A. Janssen, Mathilde Jalving, Tomás Mauro van Emden, Fabrizio de Ponti, Robert Likic, João Costa, Marc Labriffe, Charlotte L. Bekker, Carlotta Lunghi, Elisabetta Poluzzi, Michiel A. van Agtmael, Yolande Voskes, Jelle Tichelaar   +22 more
wiley   +1 more source

Characterization of DIP-2-mediated ubiquitination and degradation of the PML tumor suppressor protein

, 2010
Promyelocytic leukemia protein (簡稱PML)為一種抑癌蛋白。其會於細胞核中形成特殊的斑點狀構造，稱為PML-nuclear body (PML-NB)。PML-NB參與許多不同細胞生理功能的調控，例如誘發細胞凋亡、抑制細胞生長與促使細胞老化。當細胞受到壓力時，PML蛋白表現量會上升；反之，在人類腫瘤細胞中常出現PML蛋白消失的現象。然而，目前調控PML蛋白穩定性的因子之研究尚未透徹。在這篇論文中我們發現，BTB-Kelch蛋白DIP-2扮演著負調節者的角色 ...
江政達, Chiang, Cheng-Ta
core  

Characterization of Immune Responses to RBD‐SD1 Nanoparticle Vaccines Derived From ACE2‐Capable HKU5‐CoV‐2, NeoCoV, and HKU5 Merbecoviruses

Biotechnology and Bioengineering, EarlyView.
SpyCatcher‐mi3 nanoparticles presenting HKU5, NeoCoV, and HKU5‐CoV‐2 RBD‐SD1 induced strong, cross‐reactive IgG responses in immunized mice. The surrogate virus neutralization test demonstrated strong activity in sera from homologous vaccination. ABSTRACT Recent discoveries of merbecoviruses such as HKU5, NeoCoV, and HKU5‐CoV‐2 that use angiotensin ...
Peter J. Halfmann, Jeong Soo Lee, Augustine Duffy, Tong Wang, Bingcheng Huang, James Z. Kurdi, Ajay Inampudi, Natasha Chen, Elizabeth Frimpong, Carmen Rai, Yoshihiro Kawaoka, Ravi S. Kane   +11 more
wiley   +1 more source

Purification, Fluorescent Labeling, and Detyrosination of Mammalian Cell Tubulin for Biochemical Assays

Cytoskeleton, EarlyView.
ABSTRACT Microtubules play essential roles in numerous cellular processes. All microtubules are built from the protein tubulin, yet individual microtubules can differ spatially and temporally due to their tubulin isotype composition and post‐translational modifications (PTMs).
Ezekiel C. Thomas, Yang Yue, Morgan L. Pimm, Takashi Hotta, Ryoma Ohi, Kristen J. Verhey   +5 more
wiley   +1 more source

Post-translational modifications of PML: consequence and implications

Frontiers in Oncology, 2013
The tumor suppressor promyelocytic leukemia protein (PML) predominantly resides in a structurally distinct sub-nuclear domain called PML nuclear bodies (NBs).
Xiwen eCheng, Hung-Ying eKao
doaj   +1 more source