Results 121 to 130 of about 36,450 (302)

[The study of one case of APL with rare cryptic PML-RARα fusion gene and the literatures review].

open access: green, 2016
Y F Wang   +6 more
openalex   +2 more sources

Variation in Stabilization and Resuscitation Practices at Birth of Preterm Infants Among 12 National or Regional Neonatal Networks

open access: yesActa Paediatrica, EarlyView.
ABSTRACT Aim Neonatal resuscitation follows national or regional guidelines, but uptake varies in clinical practice. This study aimed to examine variations in reported delivery room practices for infants < 29 weeks' gestation across neonatal units in 12 networks of the International Network for Evaluating Outcomes in Neonates.
Maria Fernanda de Almeida   +676 more
wiley   +1 more source

PML–RARα induces all-trans retinoic acid-dependent transcriptional activation through interaction with MED1 [PDF]

open access: bronze, 2019
Tomoya Fukuoka   +6 more
openalex   +1 more source

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

open access: yesEuropean Journal of Haematology, EarlyView.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source

Feasibility and Safety of Venetoclax for Cytoreduction During Induction Therapy in Newly Diagnosed Acute Promyelocytic Leukemia

open access: yesEuropean Journal of Haematology, EarlyView.
ABSTRACT Objective This study aimed to evaluate the feasibility and safety of venetoclax as a cytoreductive strategy during induction therapy in newly diagnosed acute promyelocytic leukemia (APL), and to provide an exploratory description of its early efficacy.
Yu Wang   +3 more
wiley   +1 more source

A manually curated network of the PML nuclear body interactome reveals an important role for PML-NBs in SUMOylation dynamics

open access: yesInternational Journal of Biological Sciences, 2010
Promyelocytic Leukaemia Protein nuclear bodies (PML-NBs) are dynamic nuclear protein aggregates. To gain insight in PML-NB function, reductionist and high throughput techniques have been employed to identify PML-NB proteins.
Ellen Van Damme, Kris Laukens, Thanh Hai Dang, Xaveer Van Ostade
doaj  

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

open access: yesThe FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna   +5 more
wiley   +1 more source

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