Results 141 to 150 of about 100,358 (268)
European Journal of Haematology, EarlyView.SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley +1 more source
The FEBS Journal, EarlyView.Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna +5 more
wiley +1 more source
International Journal of Biological Sciences, 2010 Promyelocytic Leukaemia Protein nuclear bodies (PML-NBs) are dynamic nuclear protein aggregates. To gain insight in PML-NB function, reductionist and high throughput techniques have been employed to identify PML-NB proteins.
Ellen Van Damme, Kris Laukens, Thanh Hai Dang, Xaveer Van Ostade
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International Journal of Laboratory Hematology, EarlyView.ABSTRACT Hematologic emergencies are urgent health conditions which result in significant mortality and morbidity unless timely therapeutic measures are taken. Therapeutic success depends on their timely and accurate recognition by hematology laboratory services.
Ganna Shestakova +2 more
wiley +1 more source
Journal of Fish Biology, EarlyView.Abstract Electroanaesthesia using electric fish handling gloves induced rapid and reversible sedation of Atlantic mackerel (Scomber scombrus) during surgical tagging without observable adverse effects on behaviour or tag retention. In the laboratory, survival analyses revealed that longer handling times and smaller body sizes significantly reduced ...
Caliyena R. Brown +4 more
wiley +1 more source
Journal of Anatomy, EarlyView.Aging of bone density (BV/TV) is regional: Forelimb [left] elements gain bone sporadically (orange) but hind limb elements [right] lose bone globally (blue). Abstract Globally, human population structure is quickly trending older, increasing the prevalence and systemic burden of age‐related skeletal disorders such as osteoporosis.
Cassandra M. Turcotte +16 more
wiley +1 more source
Journal of Clinical Nursing, EarlyView.ABSTRACT Aim To analyse predictors of burnout in nursing professionals during and after the COVID‐19 pandemic. Design Cohort study. Method A two‐phase study conducted during the COVID‐19 pandemic's peak (2020) and post‐vaccination period (2022). Data from nursing professionals of four hospitals in southern Brazil included sociodemographic, occupational,
Miguel Lucas Silva da Paixão +7 more
wiley +1 more source
Measuring Firm Greenness: A Comprehensive Review of Corporate Sustainability Indicators
Journal of Economic Surveys, EarlyView.ABSTRACT The major global challenges of climate change, environmental degradation, and resource scarcity have gained centrality in policymaking and academia, with a growing body of research exploring the interlinkages among economic growth, trade, environmental outcomes, and policy interventions.
Maria Laura Pupo, Anna D'Ambrosio
wiley +1 more source
Journal of Sleep Research, Volume 34, Issue 2, April 2025.Summary The world‐wide prevalence of insomnia disorder reaches up to 10% of the adult population. Women are more often afflicted than men, and insomnia disorder is a risk factor for somatic and mental illness, especially depression and anxiety disorders.
Dieter Riemann +13 more
wiley +1 more source
Cytoplasmic function of mutant PML and PML-RARalpha
, 2006 The promyelocytic leukemia (PML) tumor suppressor of acute promyelocytic leukemia (APL) regulates major apoptotic and growth-suppressive pathways. In APL, PML is involved in a chromosomal translocation generating the PML-retinoic acid receptor-{alpha} (RAR{alpha}) fusion protein. Two missense mutations in the remaining PML alleles have been identified,
Bellodi C +7 more
openaire +1 more source