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Results 151 to 160 of about 42,451 (299)

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, EarlyView.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont +2 more
wiley +1 more source

PML as a neuroprotective guardian: Leveraging nuclear protein quality control to mitigate neurotoxicity of an ALS‐associated NEK1 variant

The FEBS Journal, EarlyView.
Insoluble protein aggregates are a hallmark of neurodegenerative diseases like amyotrophic lateral sclerosis (ALS). The ubiquitin–proteasome system (UPS) serves as a neuroprotective quality control mechanism that clears aggregates. PML nuclear bodies (NBs) were proposed to serve as hubs for SUMO‐primed ubiquitylation and degradation of misfolded ...
Tabea Stark, Stefan Müller
wiley +1 more source

Hodgkin and non‐Hodgkin lymphomas in the post‐antiretroviral therapy era according to HIV virological suppression

HIV Medicine, EarlyView.
Abstract Objectives Lymphomas remain among the most frequent HIV‐associated malignancies, with risk persisting despite effective virological control. This study describes the clinical, epidemiological and prognostic characteristics of lymphomas (both Hodgkin [HL] and non‐Hodgkin [NHL]) in people living with HIV (PLWH), according to virological ...
Teresa Aldámiz‐Echevarria +555 more
wiley +1 more source

Asian Pacific Association of Gastroenterology (APAGE) Clinical Practice Guidelines on the Use of Small Molecules and IL‐23 p19 Inhibitors in Ulcerative Colitis and Crohn's Disease

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Ulcerative colitis (UC) and Crohn's disease (CD) are increasingly prevalent in the Asia Pacific region, necessitating updated, region‐specific guidance on advanced therapies. Targeted small molecule agents, such as filgotinib, tofacitinib, upadacitinib, etrasimod, and ozanimod; and the IL‐23 p19 inhibitors (guselkumab, mirikizumab ...
Choon Jin Ooi +34 more
wiley +1 more source

Retrieval of the phytoplankton size classes from GOCI data

, 2014
The phytoplankton size class (PSC) is one of key factor for the ecological and biogeochemical processes in the ocean environment. In recent years, remote sensed data has been used to determine the global distribution of PSC and phytoplankton functional ...
Robert Brewin +5 more
core

Measuring Firm Greenness: A Comprehensive Review of Corporate Sustainability Indicators

Journal of Economic Surveys, EarlyView.
ABSTRACT The major global challenges of climate change, environmental degradation, and resource scarcity have gained centrality in policymaking and academia, with a growing body of research exploring the interlinkages among economic growth, trade, environmental outcomes, and policy interventions.
Maria Laura Pupo, Anna D'Ambrosio
wiley +1 more source

Application of a coupled physic-biogeochemical model into the Northwestern Pacific

, 2013
In this study, a coupled 3D physico-biogeochemical model based on the POLCOMS and theERSEM models has been applied on the Northwestern pacific. The model grid is 1/10° horizontalresolution on a regular latitude-longitude and has 40 s-coordinate levels in
강현우, 김한나, 소재귀
core

Chronic insomnia, REM sleep instability and emotional dysregulation: A pathway to anxiety and depression?

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary The world‐wide prevalence of insomnia disorder reaches up to 10% of the adult population. Women are more often afflicted than men, and insomnia disorder is a risk factor for somatic and mental illness, especially depression and anxiety disorders.
Dieter Riemann +13 more
wiley +1 more source

One‐Session Cognitive Behavioural Therapy for Insomnia in Integrated Primary Care: A Preliminary Study

Journal of Sleep Research, EarlyView.
ABSTRACT Chronic insomnia is commonly reported in primary care settings. One‐session cognitive behavioural therapy for insomnia (CBT‐I) is a brief intervention designed to fit the fast‐paced nature of primary care but has not been studied in this context.
Jamie L. Walker +6 more
wiley +1 more source

Periodontal Disease and Salivary Gland Dysfunction in Neurofibromatosis Type 1: A Case–Control Study

Oral Diseases, EarlyView.
ABSTRACT Objectives Neurofibromatosis type 1 (NF1) presents with diverse systemic and oral manifestations. The aim of this study was to investigate the periodontal status and salivary alterations in NF1 individuals. Methods A total of 38 individuals with NF1 diagnostic criteria were compared with a control group paired by age and sex.
Eloá Borges Luna +6 more
wiley +1 more source

humans
promyelocytic leukemia protein
animals

3. good health
medicine
nuclear proteins

leukemia, promyelocytic, acute
ubiquitination
transcription factors