Results 221 to 230 of about 46,902 (263)
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PML isoforms: a molecular basis for PML pleiotropic functions
Trends in Biochemical Sciences, 2022PML is a stress-responsive protein that coordinates assembly of phase-separated nuclear aggregates, known as PML nuclear bodies (PML-NBs), where a large number of protein interactors and chromatin processes are finely regulated. Tampering with the PML gene produces a variety of phenotypic consequences that include promoting or interfering with tumor ...
Martina Uggè, Rosa Bernardi
exaly +3 more sources
PML and PML nuclear bodies: Implications in antiviral defence
Biochimie, 2007 The establishment of an intracellular antiviral state is the defining activity of interferons (IFNs) as well as the property that permitted their discovery. Several pathways have been implicated in resistance to viral infection in IFN-treated cells, one of which implicates the ProMyelocytic Leukaemia (PML) protein and PML nuclear bodies (NBs, also ...
Everett, Roger, Chelbi-Alix, Mounira
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Mobile foci of Sp100 do not contain PML: PML bodies are immobile but PML and Sp100 proteins are not
Journal of Structural Biology, 2002PML bodies are nuclear organelles that are associated with various diseases and are suggested to be involved in multiple cellular activities including transcriptional regulation, apoptosis, and antiviral defence. Because many proteins with different functions aggregate in PML bodies, it has also been suggested that these bodies function as nuclear ...
Hans J Tanke +2 more
exaly +3 more sources
Role of cytoplasmic forms of PML and PML-RARα in the response to therapy
Toxicology, 2006 The PML tumour suppressor of acute promyelocytic leukaemia (APL) regulates major apoptotic and growth suppressive pathways. In APL, one PML allele is involved in a chromosomal translocation generating the PML-RARα fusion protein. Two missense mutations in the remaining PML allele have been identified, which give rise to a truncated cytoplasmic PML ...
Bellodi C +7 more
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Regulation of NF-κB by PML and PML-RARα
, 2014 The transcription factor NF-κB is the master regulator of the immune response but also acts broadly to regulate gene expression that influences cell survival, proliferation and differentiation. Post-translational modification of NF-κB, phosphorylation in particular, is essential for the transactivation activity of NF-κB. Promyelocytic Leukemia (PML) is
Ahmed, Abrar
core +3 more sources
Performance of regular PML, CFS-PML, and second-order PML for waveguide problems
Microwave and Optical Technology Letters, 2006The performance of regular, complex frequency shifted (CFS), and second-order perfectly matched layers (PMLs) is studied for the numerical simulation of waveguide problems. The limitations of each PML is clearly demonstrated. It is shown that the second-order PML is overall the best choice for a general problem, since the regular PML is incapable of ...
Davi Correia, Jian-Ming Jin
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Opposing effects of PML and PML/RARα on STAT3 activity
Blood, 2003Promyelocytic leukemia protein PML acts as a tumor suppressor, whereas its chimeric mutant promyelocytic leukemia/retinoic acid receptorα (PML/RARα) causes acute promyelocytic leukemia (APL). Because PML has been shown to form transcription-regulatory complexes with various molecules, we speculated that PML and/or PML/RARα might affect signal ...
Akira, Kawasaki +5 more
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A Cylindrical MRTD Algorithm With PML and Quasi-PML
IEEE Transactions on Microwave Theory and Techniques, 2013In this paper, we develop an explicit multiresolution time-domain (MRTD) scheme based on Daubechies' scaling functions with a cylindrical grid for time-domain Maxwell's equations. The stability and dispersion property of the scheme is investigated and it is shown that larger cells decrease the numerical phase error, which makes it significantly lower ...
Yawen Liu, Yiwang Chen, Bin Chen, Xin Xu
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Bulletin of the Seismological Society of America, 2003
It has been previously demonstrated that no reflection is generated when elastic (or electromagnetic) waves enter a region with Perfectly Matching Layer (PML) absorbing conditions in a continuous medium. The practical application of PMLs, however, is in numerical modeling, where the medium is discretized by either a finite-element or a finite ...
FESTA, GAETANO, Nielsen S. B.
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It has been previously demonstrated that no reflection is generated when elastic (or electromagnetic) waves enter a region with Perfectly Matching Layer (PML) absorbing conditions in a continuous medium. The practical application of PMLs, however, is in numerical modeling, where the medium is discretized by either a finite-element or a finite ...
FESTA, GAETANO, Nielsen S. B.
openaire +2 more sources