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PML isoforms: a molecular basis for PML pleiotropic functions
Trends in Biochemical Sciences, 2022PML is a stress-responsive protein that coordinates assembly of phase-separated nuclear aggregates, known as PML nuclear bodies (PML-NBs), where a large number of protein interactors and chromatin processes are finely regulated. Tampering with the PML gene produces a variety of phenotypic consequences that include promoting or interfering with tumor ...
Martina Uggè +3 more
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Bulletin of the Seismological Society of America, 2003
It has been previously demonstrated that no reflection is generated when elastic (or electromagnetic) waves enter a region with Perfectly Matching Layer (PML) absorbing conditions in a continuous medium. The practical application of PMLs, however, is in numerical modeling, where the medium is discretized by either a finite-element or a finite ...
FESTA, GAETANO, Nielsen S. B.
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It has been previously demonstrated that no reflection is generated when elastic (or electromagnetic) waves enter a region with Perfectly Matching Layer (PML) absorbing conditions in a continuous medium. The practical application of PMLs, however, is in numerical modeling, where the medium is discretized by either a finite-element or a finite ...
FESTA, GAETANO, Nielsen S. B.
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PML and PML nuclear bodies: Implications in antiviral defence
Biochimie, 2007The establishment of an intracellular antiviral state is the defining activity of interferons (IFNs) as well as the property that permitted their discovery. Several pathways have been implicated in resistance to viral infection in IFN-treated cells, one of which implicates the ProMyelocytic Leukaemia (PML) protein and PML nuclear bodies (NBs, also ...
Everett, Roger, Chelbi-Alix, Mounira
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Performance of regular PML, CFS-PML, and second-order PML for waveguide problems
Microwave and Optical Technology Letters, 2006The performance of regular, complex frequency shifted (CFS), and second-order perfectly matched layers (PMLs) is studied for the numerical simulation of waveguide problems. The limitations of each PML is clearly demonstrated. It is shown that the second-order PML is overall the best choice for a general problem, since the regular PML is incapable of ...
Davi Correia, Jian-Ming Jin
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Opposing effects of PML and PML/RARα on STAT3 activity
Blood, 2003Promyelocytic leukemia protein PML acts as a tumor suppressor, whereas its chimeric mutant promyelocytic leukemia/retinoic acid receptorα (PML/RARα) causes acute promyelocytic leukemia (APL). Because PML has been shown to form transcription-regulatory complexes with various molecules, we speculated that PML and/or PML/RARα might affect signal ...
Akira, Kawasaki +5 more
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A Cylindrical MRTD Algorithm With PML and Quasi-PML
IEEE Transactions on Microwave Theory and Techniques, 2013In this paper, we develop an explicit multiresolution time-domain (MRTD) scheme based on Daubechies' scaling functions with a cylindrical grid for time-domain Maxwell's equations. The stability and dispersion property of the scheme is investigated and it is shown that larger cells decrease the numerical phase error, which makes it significantly lower ...
Yawen Liu, Yiwang Chen, Bin Chen, Xin Xu
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PML-RARα and Its Phosphorylation Regulate PML Oligomerization and HIPK2 Stability
Cancer Research, 2013Abstract The PML gene is frequently fused to the retinoic acid receptor α (RARα) gene in acute promyelocytic leukemia (APL), generating a characteristic PML-RARα oncogenic chimera. PML-RARα disrupts the discrete nuclear speckles termed nuclear bodies, which are formed in PML, suggesting that nuclear body disruption is involved in ...
Yutaka, Shima +2 more
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