Posttranslational microtubule modification alters podocalyxin-trafficking in epithelial cells [PDF]
Frontiers in Cell and Developmental BiologyEpithelial polarization is characterized by separation of the plasma membrane into an apical and a basolateral membrane domain. This morphology is verified by cytoskeletal organization that stabilizes the cellular architecture and provides specific ...
Lena-Sophie Gorek +6 more
doaj +3 more sources
Serum Podocalyxin Level as a Potential Biomarker for Diagnosis of Nephrotic Syndrome and Prediction of Steroid Response [PDF]
Medeniyet Medical JournalObjective: Idiopathic nephrotic syndrome (NS) is a common pediatric glomerular disorder. Podocyte damage constitutes a central mechanism in its pathophysiology.
Emre LEVENTOGLU +2 more
doaj +2 more sources
Podocalyxin, Isthmin-1, and Pentraxin-3 Immunoreactivities as Emerging Immunohistochemical Markers of Fibrosis in Chronic Hepatitis B [PDF]
BiomedicinesIntroduction and Objectives: Persistent hepatic inflammation serves as a key driver of fibrogenesis in chronic hepatitis B. Fibrosis is a complex molecular and cellular process.
Müge Özgüler +3 more
doaj +2 more sources
Protective Effects of Physalis angulata on Podocythopathies Through B-Cell-Activating Factor Inhibition in Doxorubicin-Induced Nephrotic Syndrome Rat Model [PDF]
BiomedicinesBackground/Objectives: Nephrotic syndrome, a glomerular disease caused by podocyte dysfunction, is characterized by proteinuria, hypoalbuminemia, edema, and hyperlipidemia.
Astrid K. Kardani +3 more
doaj +2 more sources
A Cancer-Specific Anti-Podocalyxin Monoclonal Antibody (humPcMab-60) Demonstrated Antitumor Efficacy in Pancreatic and Colorectal Cancer Xenograft Models [PDF]
AntibodiesBackground: Podocalyxin (PODXL) has been identified as a promising therapeutic target and a potential diagnostic biomarker in various tumors. Despite the therapeutic potential of anti-PODXL monoclonal antibodies (mAbs), their further development has been
Hiroyuki Suzuki +7 more
doaj +2 more sources
The effect of SGLT2 inhibitor and HIF-PHI on the podocyte-specific molecules and cytoskeleton of diabetic podocytes [PDF]
BMC NephrologyBackground Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHI) have pleiotropic properties that may affect glomerular podocytes.
Chuanlei Li +5 more
doaj +2 more sources
Anti-Adhesive Podocalyxin Expression Is Disrupted in Recurrent Implantation Failure [PDF]
DiagnosticsObjectives: The downregulation of anti-adhesive regulatory proteins and upregulation of adhesive genes are critical for the receptive endometrium. This study was designed to determine whether switching between the anti-adhesive podocalyxin (PDX) and ...
Mustafa Tas
doaj +2 more sources
Preservation of Urinary Podocyte Markers in Diabetic Kidney Disease by Sodium-Glucose Cotransporter 2 Inhibitor Therapy [PDF]
Kidney DiseasesIntroduction: Sodium-glucose cotransporter 2 inhibitor (SGLT2i) is a standard treatment for kidney and cardiovascular protection in diabetic kidney disease (DKD). We investigated the effect of SGLT2i on the urinary podocyte-associated molecule
Chuanlei Li +5 more
doaj +2 more sources
Prediction of Possible Adverse Effects of Gestational Diabetes Mellitus on Maternal and Fetal Glomeruli by Urine and Amniotic Fluid Podocyte Degradation Products [PDF]
DiagnosticsObjectives: To compare the levels of podocyte damage markers nephrin and podocalyxin in urine samples taken at the time of gestational diabetes mellitus (GDM) diagnosis and at birth.
Fatma Tanilir Cagiran +3 more
doaj +2 more sources
Assessment of urinary podocalyxin as a biomarker of early diagnosis of hypertensive nephropathy [PDF]
The Ukrainian Biochemical Journal, 2023 Chronically high blood pressure-related kidney injury is known as hypertensive nephropathy (HN). Podocyte damage in the pathogenesis of this disease can result in the release of the sialoglycoprotein podocalyxin into the urine, so podocalyxin may be ...
I. Kostovska +5 more
doaj +1 more source