Serum Podocalyxin Level as a Potential Biomarker for Diagnosis of Nephrotic Syndrome and Prediction of Steroid Response [PDF]
Medeniyet Medical JournalObjective: Idiopathic nephrotic syndrome (NS) is a common pediatric glomerular disorder. Podocyte damage constitutes a central mechanism in its pathophysiology.
Emre LEVENTOGLU +2 more
doaj +2 more sources
Dynamics and Predictive Values of Urinary Podocyte Biomarkers Following SGLT2 Inhibition in CKD [PDF]
LifePodocyte injury is an early hallmark of chronic kidney disease (CKD) and can be influenced by SGLT2 inhibitors (SGLT2i). Early effects of SGLT2i include transient estimated glomerular filtration rate (eGFR) dip and reduced proteinuria; however, the ...
Alexandra Urs +10 more
doaj +2 more sources
Utility of urinary podocalyxin levels in patients with and without type 2 diabetic nephropathy and its correlation with renal function [PDF]
BMC Research NotesPurpose Podocalyxin is a urinary protein that may serve as a potential indicator for the early detection of diabetic nephropathy. The objectives of this study were to assess urinary podocalyxin levels in patients with and without type 2 diabetic ...
Jothivanan Perumal +2 more
doaj +2 more sources
Posttranslational microtubule modification alters podocalyxin-trafficking in epithelial cells [PDF]
Frontiers in Cell and Developmental BiologyEpithelial polarization is characterized by separation of the plasma membrane into an apical and a basolateral membrane domain. This morphology is verified by cytoskeletal organization that stabilizes the cellular architecture and provides specific ...
Lena-Sophie Gorek +6 more
doaj +2 more sources
Protective Effects of Physalis angulata on Podocythopathies Through B-Cell-Activating Factor Inhibition in Doxorubicin-Induced Nephrotic Syndrome Rat Model [PDF]
BiomedicinesBackground/Objectives: Nephrotic syndrome, a glomerular disease caused by podocyte dysfunction, is characterized by proteinuria, hypoalbuminemia, edema, and hyperlipidemia.
Astrid K. Kardani +3 more
doaj +2 more sources
Podocalyxin, Isthmin-1, and Pentraxin-3 Immunoreactivities as Emerging Immunohistochemical Markers of Fibrosis in Chronic Hepatitis B [PDF]
BiomedicinesIntroduction and Objectives: Persistent hepatic inflammation serves as a key driver of fibrogenesis in chronic hepatitis B. Fibrosis is a complex molecular and cellular process.
Müge Özgüler +3 more
doaj +2 more sources
A Cancer-Specific Anti-Podocalyxin Monoclonal Antibody (humPcMab-60) Demonstrated Antitumor Efficacy in Pancreatic and Colorectal Cancer Xenograft Models [PDF]
AntibodiesBackground: Podocalyxin (PODXL) has been identified as a promising therapeutic target and a potential diagnostic biomarker in various tumors. Despite the therapeutic potential of anti-PODXL monoclonal antibodies (mAbs), their further development has been
Hiroyuki Suzuki +7 more
doaj +2 more sources
The effect of SGLT2 inhibitor and HIF-PHI on the podocyte-specific molecules and cytoskeleton of diabetic podocytes [PDF]
BMC NephrologyBackground Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHI) have pleiotropic properties that may affect glomerular podocytes.
Chuanlei Li +5 more
doaj +2 more sources
Anti-Adhesive Podocalyxin Expression Is Disrupted in Recurrent Implantation Failure [PDF]
DiagnosticsObjectives: The downregulation of anti-adhesive regulatory proteins and upregulation of adhesive genes are critical for the receptive endometrium. This study was designed to determine whether switching between the anti-adhesive podocalyxin (PDX) and ...
Mustafa Tas
doaj +2 more sources
Preservation of Urinary Podocyte Markers in Diabetic Kidney Disease by Sodium-Glucose Cotransporter 2 Inhibitor Therapy [PDF]
Kidney DiseasesIntroduction: Sodium-glucose cotransporter 2 inhibitor (SGLT2i) is a standard treatment for kidney and cardiovascular protection in diabetic kidney disease (DKD). We investigated the effect of SGLT2i on the urinary podocyte-associated molecule
Chuanlei Li +5 more
doaj +2 more sources