Results 21 to 30 of about 7,139 (201)

Activation of Rac-1 and RhoA contributes to podocyte injury in chronic kidney disease [PDF]

, 2013
Rho-family GTPases like RhoA and Rac-1 are potent regulators of cellular signaling that control gene expression, migration and inflammation. Activation of Rho-GTPases has been linked to podocyte dysfunction, a feature of chronic kidney diseases (CKD). We
Amann, Kerstin, Babelova, Andrea, Brandes, Ralf Peter Louis, Daniel, Christoph, Fork, Christian, Jansen, Felix, Jung, Oliver, Löhn, Matthias, Pavenstädt, Hermann, Plettenburg, Oliver, Ruetten, Hartmut, Sander, Kerstin, Schäfer, Liliana, Stark, Holger   +13 more
core   +8 more sources

Ameliorative effects of glycine on cobalt chloride‐induced hepato‐renal toxicity in rats

Animal Models and Experimental Medicine, 2023
Background The important roles of liver and kidney in the elimination of injurious chemicals make them highly susceptible to the noxious activities of various toxicants including cobalt chloride (CoCl2). This study was designed to investigate the role of
Oluwafikemi Temitayo Iji, Temitayo Olabisi Ajibade, Oluwaseun Olanrewaju Esan, Omolola Victoria Awoyomi, Ademola Adetokunbo Oyagbemi, Moses Olusola Adetona, Temidayo Olutayo Omobowale, Momoh Audu Yakubu, Oluwafemi Omoniyi Oguntibeju, Evaristus Nwulia   +9 more
doaj   +1 more source

New perspectives on the renal slit diaphragm protein podocin [PDF]

Modern Pathology, 2011
Podocin is a critical component of the glomerular filtration barrier, its mutations causing recessive steroid-resistant nephrotic syndrome. A GenBank analysis of the human podocin (NPHS2) gene resulted in the possible existence of a new splice variant of podocin in the kidney, missing the in-frame of exon 5, encoding the prohibitin homology domain ...
Relle, Manfred, Cash, Hannes, Brochhausen, Christoph, Strand, Dennis, Menke, Julia, Galle, Peter R, Schwarting, Andreas   +6 more
openaire   +2 more sources

Lmx1b and FoxC Combinatorially Regulate Podocin Expression in Podocytes [PDF]

Journal of the American Society of Nephrology, 2014
Podocin is a key protein of the kidney podocyte slit diaphragm protein complex, an important part of the glomerular filtration barrier. Mutations in the human podocin gene NPHS2 cause familial or sporadic forms of renal disease owing to the disruption of filtration barrier integrity.
He, B, Ebarasi, L, Zhao, Z, Guo, J, Ojala, JR, Hultenby, K, De Val, S, Betsholtz, C, Tryggvason, K   +8 more
openaire   +2 more sources

Urinary podocin level as a predictor of diabetic kidney disease [PDF]

Journal of Nephropathology, 2019
Background: Albuminuria showed to be a deteriorating condition in diabetic kidney disease (DKD) associated with high morbidity and mortality. A need for a novel marker for early detection of DKD development and progression becomes mandating.
Abdelbassit ElShaarawy, Maha Abdelmoneim Behairy, Somia Abdelhameed Bawady, Hoda Ahmed Abdelsattar, Eman Shadad   +4 more
doaj   +1 more source

Elevated Levels of Urinary Podocyte-Derived Microparticles in Nephrotic Syndrome

Indonesian Biomedical Journal, 2023
BACKGROUND: Nephrotic syndrome (NS) is the most common glomerular disease in childhood. The proposed hypothesis for the pathogenesis of this disease has changed over time, from immune dysregulation theory and systemic circulating factors theory, to the ...
Eka Laksmi Hidayati, Bambang Supriyatno, Sudung Oloan Pardede, Partini Pudjiastuti Trihono, Dewi Sukmawati, Dewi Wulandari, Oke Rina Ramayani   +6 more
doaj   +1 more source

From Wild Vegetable to Renal Protector: The Therapeutic Potential of <i>Aralia elata</i> (Miq.) Seem. [PDF]

Food Sci Nutr
Aralia elata, a medicinal and edible wild vegetable, yields Araloside A (Ara A), a natural triterpenoid saponin. Experimental results show that Ara A, by mitigating oxidative stress and regulating ferroptosis‐related proteins via the SLC7A11/GSH/GPX4 pathway, can alleviate renal injury, reduce proteinuria, and delay glomerulosclerosis in model mice ...
Wu J, Liu Y, Xu Z, Tan H, Huang M, Jiang C, He W, Wei M, Du Z, Qiang S.   +9 more
europepmc   +2 more sources

Broadening the Spectrum of Diseases Related to Podocin Mutations [PDF]

Journal of the American Society of Nephrology, 2003
A total of 179 children with sporadic nephrotic syndrome were screened for podocin mutations: 120 with steroid resistance, and 59 with steroid dependence/frequent relapses. Fourteen steroid-resistant patients presented homozygous mutations that were associated with early onset of proteinuria and variable renal lesions, including one case with mesangial
CARIDI G, BERTELLI R, DI DUCA M, DAGNINO M, EMMA F, ONETTI MUDA A, SCOLARI F, MIGLIETTI N, MAZZUCCO, Gianna, MURER L, CARREA A, MASSELLA L, RIZZONI G, PERFUMO F, GHIGGERI GM   +14 more
openaire   +4 more sources

Evaluation of podocin in urine in horses using qualitative and quantitative methods.

PLoS ONE, 2020
No sensitive method for diagnosing early kidney dysfunction in horses has been identified so far. Many studies carried out in humans and small animals show that podocin can be useful to diagnose various kidney diseases, mainly affecting the glomeruli ...
Natalia Siwińska, Urszula Pasławska, Remigiusz Bąchor, Barbara Szczepankiewicz, Agnieszka Żak, Paulina Grocholska, Zbigniew Szewczuk   +6 more
doaj   +1 more source

In situ evaluation of podocin in normal and glomerular diseases [PDF]

Kidney International, 2003
Mutations of the NPHS2 gene are responsible for autosomal-recessive steroid-resistant nephrotic syndrome. Its product, podocin, faces the slit diaphragm area with its two ends in the cytoplasm of foot processes.We generated rabbit polyclonal antibodies against conjugated peptides from human podocin N- and C-termini, and studied podocin and synaptopodin
Horinouchi, Izumi, Nakazato, Hitoshi, Kawano, Tomoyasu, Iyama, Ken-Ichi, Furuse, Akio, Arizono, Kenji, Machida, Jiro, Sakamoto, Tamami, Endo, Fumio, Hattori, Shinzaburo   +9 more
openaire   +2 more sources