Results 61 to 70 of about 6,561 (137)

Senegenin regulates the mechanism of insomnia through the Keap1/Nrf2/PINK1/Parkin pathway mediated by GAD67

Journal of Sleep Research, Volume 34, Issue 3, June 2025.
Summary GAD67 impacts insomnia as a key enzyme catalysing the conversion of glutamate (Glu) to gamma‐aminobutyric acid (GABA). Senegenin enhances neuroprotection and is used widely to treat insomnia and other neurological diseases. This study aimed to investigate how senegenin regulates insomnia through a GAD67‐mediated signalling pathway.
Honglin Jia, Xu Chen, Zhengting Liang, Ruining Liang, Jinhong Wu, Yanling Hu, Wenjun Cui, Xingping Zhang   +7 more
wiley   +1 more source

Tangeretin Improves the Memory of Swiss Mice, Suggesting Potential Molecular Interventions Through Animal Behavior Assessments and In Silico Studies

Brain and Behavior, Volume 15, Issue 5, May 2025.
Swiss mice treated with tangeretin showed better performance in marble burying, dust removal, and trained swimming tests, resulting elevation of memory performance, problem‐solving, and motor coordination. The compound also demonstrated a remarkable binding affinity toward the D2 receptor with favorable pharmacokinetic properties in in silico analysis ...
Md. Sakib Al Hasan, Mohd Shahnawaz Khan, Arusha Ayub, Raihan Chowdhury, Emon Mia, Md. Shadin, Md. Showkot Akbor, Muhammad Torequl Islam, Md. Shimul Bhuia   +8 more
wiley   +1 more source

The primers used for RT-qPCR experiment in Polygala tenuifolia Willd.

The primers used for RT-qPCR experiment in Polygala tenuifolia Willd.
Xian Gu (5858801), Xiaowei Li (620087), Yunsheng Zhao (18142460), Yuguang Zheng (10762689), Jingyi Bi (14103966), Fuying Mao (18142454), Yang Liu (4829), Jinmiao Qiu (18142457), Xiaofang Ma (829740)   +8 more
core   +1 more source

Natural products targeting tumour angiogenesis

British Journal of Pharmacology, Volume 182, Issue 10, Page 2094-2136, May 2025.
Abstract Tumour angiogenesis is the formation of new blood vessels to support the growth of a tumour. This process is critical for tumour progression and metastasis, making it an attractive approach to cancer therapy. Natural products derived from plants, animals or microorganisms exert anti‐angiogenic properties and can be used to inhibit tumour ...
Xiaohua Lu, Lara Johanna Friedrich, Thomas Efferth   +2 more
wiley   +1 more source

Polygalae Radix: review of metabolites, pharmacological activities and toxicology

Frontiers in Pharmacology
Polygalae Radix: is the dried root of Polygala tenuifolia Willd. or Polygala sibirica L., which has the effect of improving memory and cognitive function in traditional Chinese medicine.
Meihua Liu, Xin Wang, Dejiang Gao
doaj   +1 more source

New Acylated Triterpene Glycosides from the Roots of

Natural Product Communications, 2014
Two new and five known acylated triterpene glycosides were isolated from the MeOH extract of the roots of Polygala tenuifolia. Based on extensive spectroscopic analysis, including 2D NMR experiments, and the results of alkaline hydrolysis, the structures
Minpei Kuroda, Takaaki Shizume, Yoshihiro Mimaki   +2 more
doaj   +1 more source

Woody and Herbaceous Species Diversity Respond Differently to Environmental Variables in Semiarid Areas in Ghana

Ecology and Evolution, Volume 15, Issue 4, April 2025.
In the drylands of Ghana, the relative importance of various environmental drivers for plant species composition and diversity is still poorly understood and this affects the identification and implementation of appropriate management strategies.
Reginald T. Guuroh, Bertrand F. Nero, Fousseni Folega, Kwame A. Oduro, Fred Kalanzi, Gloria K. Adeyiga, Adu‐Gyamfi Asamoah, Mark Appiah, Miracle Obeng, E. Amponsah   +9 more
wiley   +1 more source

Response surface methodology for optimization of extracting polysaccharide from Polygala tenuifolia willd. and antioxidant evaluation

, 2016
The optimum condition of ultrasonic extraction of Polygala tenuifolia Willd. Polysaccharide (PTP) was investigated. The results showed, the optimum condition was ultrasonic extraction time 30 min, ultrasonic extraction, temperature 67 ℃, ratio of water ...
Qian, WANG, Lanfang, WU, Yuguang, ZHENG, Yongshuai, JING, Yuping, YAN, Aimin, JIANG   +5 more
core   +1 more source

Peri‐Carpathian Forest‐Steppe Grasslands: Distribution, Indicator Species and Extreme Species Richness

Journal of Biogeography, Volume 52, Issue 3, Page 712-721, March 2025.
ABSTRACT Aim We aim to refine the definition of peri‐Carpathian forest‐steppe grasslands, provide an updated distribution map, identify consensus indicator species and summarise data on their extreme species richness. Location East‐Central Europe (Czech Republic, Austria, Slovakia, Hungary, Romania, Ukraine). Taxon Vascular plants.
Jan Roleček, Pavel Dřevojan, Petra Hájková, Wolfgang Willner, Monika Janišová, Attila Lengyel, Illya Chorney, Anna Kuzemko, Irina Goia, Kiril Vassilev, Michal Hájek   +10 more
wiley   +1 more source

Medicinal Plants and Herbal Medicines for Managing Anxiety and Depression via Gut Microbiota Modulation

Advanced Gut &Microbiome Research, Volume 2025, Issue 1, 2025.
Currently, there is a high prevalence of depression and anxiety worldwide. Recent research about psychopharmacology based on natural products has revealed promising alternatives in mental disorder’s treatment. Medicinal plants are rich in bioactive compounds with beneficial effects on many diseases, among these, mental illnesses.
Priscilla Magro Reque, Adriano Brandelli, Cristina Mayumi Sasaki Miyazaki, Ana Flávia Marçal Pessoa, Jian. Wu   +4 more
wiley   +1 more source