Complexity-Building ESIPT-Assisted Synthesis of Fused Polyheterocyclic Sulfonamides [PDF]
Molecules, 2023 Excited State Intramolecular Proton Transfer (ESIPT), originally discovered and explored in depth in a number of extensive photophysical studies, is more recently rediscovered as a powerful synthetic tool, offering rapid access to complex ...
Srinivas Beduru, Andrei G. Kutateladze
doaj +4 more sources
Free-radical cyclization approach to polyheterocycles containing pyrrole and pyridine rings [PDF]
Beilstein Journal of Organic Chemistry, 2021 A wide range of derivatives with new pyrido[2,1-a]pyrrolo[3,4-c]isoquinoline skeleton was synthesized by free-radical intramolecular cyclization of o-bromophenyl-substituted pyrrolylpyridinium salts using the (TMS)3SiH/AIBN system.
Ivan P. Mosiagin +5 more
doaj +3 more sources
Copper-catalyzed modular assembly of polyheterocycles [PDF]
The Journal of Organic Chemistry, 2020 Easy operation, readily accessible starting materials, and short syntheses of the privileged scaffold indeno[1,2-c]isoquinolinone were achieved by an multicomponent reaction (MCR)-based protocol via an ammonia-Ugi-four component reaction (4CR)/copper ...
Dömling, Alexander +5 more
core +7 more sources
Synthesis of New Polyheterocyclic Pyrrolo[3,4-b]pyridin-5-ones via an Ugi-Zhu/Cascade/Click Strategy [PDF]
Molecules, 2023 A diversity-oriented synthesis (DOS) of two new polyheterocyclic compounds was performed via an Ugi-Zhu/cascade (N-acylation/aza Diels-Alder cycloaddition/decarboxylation/dehydration)/click strategy, both step-by-step to optimize all involved ...
Roberto E. Blanco-Carapia +4 more
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Green Synthesis and Catalysis, 2023 A highly efficient, transition-metal- and light-free approach to polyheterocycles via regioselective cascade radical cyclization is developed. The redox-neutral protocol has a broad substrate scope with good functional group tolerance and probably ...
Qijing Zhang +4 more
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Pictet–Spengler-Based Multicomponent Domino Reactions to Construct Polyheterocycles
Pharmaceutical Fronts, 2023 The Pictet–Spengler reaction is one of the important methodological arsenals in synthetic and medicinal chemistry, acting as an amenable tool for preparing tetrahydroisoquinoline, tetrahydro-β-carbolines, polycyclic skeletons, and value-added products ...
Jun-Duo Hu +2 more
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Aryl Methyl Ketones: Versatile Synthons in the Synthesis of Heterocyclic Compounds [PDF]
SynOpen, 2022 The synthesis of aromatic heterocycles has attracted substantial attention due to the abundance of these heterocycles in drug molecules, natural products, and other compounds of biological interest.
Shabber Mohammed +2 more
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One-Pot Sequence of Staudinger/aza-Wittig/Castagnoli–Cushman Reactions Provides Facile Access to Novel Natural-like Polycyclic Ring Systems [PDF]
Molecules, 2022 Realization of the one-pot Staudinger/aza-Wittig/Castagnoli–Cushman reaction sequence for a series of azido aldehydes and homophthalic anhydrides is described. The reaction proceeded at room temperature and delivered novel polyheterocycles related to the
Rodion Lebedev +4 more
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Complex Polyheterocycles and the Stereochemical Reassignment of Pileamartine A via Aza-Heck Triggered Aryl C-H Functionalization Cascades. [PDF]
J Am Chem Soc, 2021 Structurally complex benzo- and spiro-fused N-polyheterocycles can be accessed via intramolecular Pd(0)-catalyzed alkene 1,2-aminoarylation reactions. The method uses N-(pentafluorobenzoyloxy)carbamates as the initiating motif, and this allows aza-Heck ...
Jones BT +7 more
europepmc +2 more sources
Mo-Catalyzed One-Pot Synthesis of N-Polyheterocycles from Nitroarenes and Glycols with Recycling of the Waste Reduction Byproduct. Substituent-Tuned Photophysical Properties. [PDF]
Chemistry, 2021 A catalytic domino reduction–imine formation–intramolecular cyclization–oxidation for the general synthesis of a wide variety of biologically relevant N‐polyheterocycles, such as quinoxaline‐ and quinoline‐fused derivatives, and phenanthridines, is ...
Hernández-Ruiz R +6 more
europepmc +2 more sources