Complexity-Building ESIPT-Assisted Synthesis of Fused Polyheterocyclic Sulfonamides [PDF]
Molecules, 2023 Excited State Intramolecular Proton Transfer (ESIPT), originally discovered and explored in depth in a number of extensive photophysical studies, is more recently rediscovered as a powerful synthetic tool, offering rapid access to complex ...
Srinivas Beduru, Andrei G. Kutateladze
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Palladium‐Catalyzed Dual Csp2─Csp3 Bond Formation: A Versatile Platform for the Synthesis of Benzo‐Fused Heterocycles [PDF]
Advanced ScienceTransition‐metal‐catalyzed transformations offer a powerful approach to rapidly synthesize complex benzo‐fused heterocycles, crucial for drug and material development.
Jiahui Huang +9 more
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Synthesis of New Polyheterocyclic Pyrrolo[3,4-b]pyridin-5-ones via an Ugi-Zhu/Cascade/Click Strategy [PDF]
Molecules, 2023 A diversity-oriented synthesis (DOS) of two new polyheterocyclic compounds was performed via an Ugi-Zhu/cascade (N-acylation/aza Diels-Alder cycloaddition/decarboxylation/dehydration)/click strategy, both step-by-step to optimize all involved ...
Roberto E. Blanco-Carapia +4 more
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Aryl Methyl Ketones: Versatile Synthons in the Synthesis of Heterocyclic Compounds [PDF]
SynOpen, 2022 The synthesis of aromatic heterocycles has attracted substantial attention due to the abundance of these heterocycles in drug molecules, natural products, and other compounds of biological interest.
Shabber Mohammed +2 more
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One-Pot Sequence of Staudinger/aza-Wittig/Castagnoli–Cushman Reactions Provides Facile Access to Novel Natural-like Polycyclic Ring Systems [PDF]
Molecules, 2022 Realization of the one-pot Staudinger/aza-Wittig/Castagnoli–Cushman reaction sequence for a series of azido aldehydes and homophthalic anhydrides is described. The reaction proceeded at room temperature and delivered novel polyheterocycles related to the
Rodion Lebedev +4 more
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Free-radical cyclization approach to polyheterocycles containing pyrrole and pyridine rings [PDF]
Beilstein Journal of Organic Chemistry, 2021 A wide range of derivatives with new pyrido[2,1-a]pyrrolo[3,4-c]isoquinoline skeleton was synthesized by free-radical intramolecular cyclization of o-bromophenyl-substituted pyrrolylpyridinium salts using the (TMS)3SiH/AIBN system.
Ivan P. Mosiagin +5 more
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Recent Developments in Azomethine Ylide-Initiated Double Cycloadditions [PDF]
MoleculesAzomethine ylides (AMYs) have a nitrogen–carbon double bond and an electron lone pair on the nitrogen atom. They are essential 1,3-dipoles for [3+2] cycloadditions in the synthesis of pyrrolidine-containing heterocycles.
Tieli Zhou +4 more
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Synthetic routes to benzimidazole-based fused polyheterocycles [PDF]
ARKIVOC, 2010 The review article represents a survey covering the synthetic strategies leading to benzimidazole- based fused polyheterocyclic systems utilizing simple reactive benzimidazole synthons since 1980. The polyheterocyclic systems are classified based on the number of rings; tetra-, penta-, hexa- and hepta-fused ring systems.
Kamal M. Dawood, Bakr F. Abdel-Wahab
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Enantioselective aza-electrophilic dearomatization of naphthalene derivatives [PDF]
Nature CommunicationsThe catalytic asymmetric dearomatization of naphthalenes is a pivotal strategy for generating enantioenriched three-dimensional aliphatic polycycles from flat aromatic precursors.
Jun Liu +5 more
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Diverse Synthesis of Fused Polyheterocyclic Compounds via [3 + 2] Cycloaddition of In Situ-Generated Heteroaromatic N-Ylides and Electron-Deficient Olefins [PDF]
Molecules, 2023 [3 + 2] Cycloaddition reactions of heteroaromatic N-ylides with electron-deficient olefins have been developed. The heteroaromatic N-ylides, in situ generated from N-phenacylbenzothiazolium bromides, can smoothly react with maleimides under very mild ...
Zhen-Hua Wang +7 more
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