Results 11 to 20 of about 1,317 (206)

Palladium‐Catalyzed Dual Csp2─Csp3 Bond Formation: A Versatile Platform for the Synthesis of Benzo‐Fused Heterocycles [PDF]

Advanced Science
Transition‐metal‐catalyzed transformations offer a powerful approach to rapidly synthesize complex benzo‐fused heterocycles, crucial for drug and material development.
Jiahui Huang, Yuantao You, Yijian Ma, Xingying He, Yixiao Li, Arunachalam Kesavan, Chengzhi Jin, Chengshuo Shen, Min Zhang, Kedong Yuan   +9 more
doaj   +3 more sources

Molybdenum‐Catalyzed One‐Pot Multi‐Step Synthesis of N‐Polyheterocycles from Nitroarenes and Glycols [PDF]

European Journal of Organic Chemistry, Volume 27, Issue 18, May 13, 2024.
We report the efficient, sustainable one-pot synthesis of a wide variety of N-polyheterocycles, such as imidazo-quinolines and quinoxalines, and furoquinolines, from easily available nitroaromatics and glycols via a molybdenum catalytic domino reduction ...
Cases, Nuria, Gómez Gil, Sara, Hernández Ruiz, Raquel, Pedrosa Sáez, María de los Remedios, Rubio Presa, Rubén, Sanz Díez, Roberto, Suárez Pantiga, Samuel   +6 more
core   +3 more sources

Highly Stereoselective Ugi/Pictet-Spengler Sequence. [PDF]

J Org Chem, 2022
Discovering novel synthetic routes for rigid nitrogen-containing polyheterocycles using sustainable, atom-economical, and efficient (= short) synthetic pathways is of high interest in organic chemistry. Here, we describe an operationally simple and short
Zhang B, Kurpiewska K, Dömling A.
europepmc   +4 more sources

Recent Developments in Azomethine Ylide-Initiated Double Cycloadditions [PDF]

Molecules
Azomethine ylides (AMYs) have a nitrogen–carbon double bond and an electron lone pair on the nitrogen atom. They are essential 1,3-dipoles for [3+2] cycloadditions in the synthesis of pyrrolidine-containing heterocycles.
Tieli Zhou, Xiaofeng Zhang, Yan Jan Sheng, Desheng Zhan, Wei Zhang   +4 more
doaj   +2 more sources

Cp∗Rh/Ag catalyzed C–H activation/cyclization sequences of NH-sulfoximines to fused aza-polyheterocycles under gentle conditions

Green Synthesis and Catalysis, 2023
Disclosed herein is a novel Rh/Ag co-catalyzed SNH directed C–H activation and C–H/N–H bond functionalization protocol of free NH-sulfoximines with hypervalent iodonium ylides.
Jiapian Huang, Fei Liu, Feihua Du, Linghui Zeng, Zhiyuan Chen   +4 more
doaj   +2 more sources

Synthetic routes to benzimidazole-based fused polyheterocycles [PDF]

ARKIVOC, 2010
The review article represents a survey covering the synthetic strategies leading to benzimidazole- based fused polyheterocyclic systems utilizing simple reactive benzimidazole synthons since 1980. The polyheterocyclic systems are classified based on the number of rings; tetra-, penta-, hexa- and hepta-fused ring systems.
Kamal M. Dawood, Bakr F. Abdel-Wahab
doaj   +2 more sources

Enantioselective aza-electrophilic dearomatization of naphthalene derivatives [PDF]

Nature Communications
The catalytic asymmetric dearomatization of naphthalenes is a pivotal strategy for generating enantioenriched three-dimensional aliphatic polycycles from flat aromatic precursors.
Jun Liu, Haina Liu, Meijuan Zhou, Xiaolong Yu, Gang Zhao, Hongyu Wang   +5 more
doaj   +2 more sources

Rhodacyclopentanones as Linchpins for the Atom Economical Assembly of Diverse Polyheterocycles [PDF]

Journal of the American Chemical Society, 2020
We outline a conceptual blueprint that provides direct and atom economical access to a wide range of complex polyheterocycles. Our method capitalizes on the ambiphilic reactivity of rhodacyclopentanones that arise upon exposure of cyclopropanes to Rh(I ...
Bertrand, Sophie M., Bower, John F., Boyd, Olivia, Wang, Gang-Wei, Young, Tom A.   +4 more
core   +3 more sources

Intramolecular Povarov Reactions for the Synthesis of Chromenopyridine Fused 2-Pyridone Polyheterocycles Binding to α-Synuclein and Amyloid-β Fibrils. [PDF]

J Org Chem, 2020
A BF3·OEt2 catalyzed intramolecular Povarov reaction was used to synthesize 15 chromenopyridine fused thiazolino-2-pyridone peptidomimetics. The reaction works with several O-alkylated salicylaldehydes and amino functionalized thiazolino-2-pyridones, to ...
Adolfsson DE, Tyagi M, Singh P, Deuschmann A, Ådén J, Gharibyan AL, Jayaweera SW, Lindgren AEG, Olofsson A, Almqvist F, Almqvist F.   +10 more
europepmc   +2 more sources

An easy access to furan fused polyheterocyclic systems [PDF]

Molecules, 2022
Nitrostilbenes characterized by two different or differently substituted aryl moieties can be obtained from the initial ring-opening of 3-nitrobenzo[b]thiophene with amines.
Alice Benzi, Cinzia Tavani, Domenico Spinelli, Gianluca Giorgi, Giovanni Petrillo, Lara Bianchi, Massimo Maccagno   +6 more
core   +5 more sources