Results 11 to 20 of about 888 (170)

Copper-Catalyzed Modular Assembly of Polyheterocycles [PDF]

The Journal of Organic Chemistry, 2020
Easy operation, readily accessible starting materials, and short syntheses of the privileged scaffold indeno[1,2-c]isoquinolinone were achieved by an multicomponent reaction (MCR)-based protocol via an ammonia-Ugi-four component reaction (4CR)/copper-catalyzed annulation sequence.
Qian Wang, Jesse Tuinhof, Kumchok C. Mgimpatsang, Katarzyna Kurpiewska, Justyna Kalinowska-Tluscik, Alexander Dömling   +5 more
openaire   +7 more sources

Molybdenum‐Catalyzed One‐Pot Multi‐Step Synthesis of N‐Polyheterocycles from Nitroarenes and Glycols [PDF]

European Journal of Organic Chemistry, Volume 27, Issue 18, May 13, 2024.
We report the efficient, sustainable one-pot synthesis of a wide variety of N-polyheterocycles, such as imidazo-quinolines and quinoxalines, and furoquinolines, from easily available nitroaromatics and glycols via a molybdenum catalytic domino reduction ...
Cases, Nuria, Gómez Gil, Sara, Hernández Ruiz, Raquel, Pedrosa Sáez, María de los Remedios, Rubio Presa, Rubén, Sanz Díez, Roberto, Suárez Pantiga, Samuel   +6 more
core   +2 more sources

An Easy Access to Furan-Fused Polyheterocyclic Systems [PDF]

Molecules, 2022
Nitrostilbenes characterized by two different or differently substituted aryl moieties can be obtained from the initial ring-opening of 3-nitrobenzo[b]thiophene with amines. Such versatile building blocks couple the well-recognized double electrophilic reactivity of the nitrovinyl moiety (addition to the double bond, followed by, e.g., intramolecular ...
Alice Benzi, Lara Bianchi, Gianluca Giorgi, Massimo Maccagno, Giovanni Petrillo, Domenico Spinelli, Cinzia Tavani   +6 more
openaire   +6 more sources

Highly Stereoselective Ugi/Pictet-Spengler Sequence. [PDF]

J Org Chem, 2022
Discovering novel synthetic routes for rigid nitrogen-containing polyheterocycles using sustainable, atom-economical, and efficient (= short) synthetic pathways is of high interest in organic chemistry. Here, we describe an operationally simple and short
Zhang B, Kurpiewska K, Dömling A.
europepmc   +4 more sources

2-Benzyl-7-(4-chlorophenyl)-3-morpholino-6-((1-phenyl-1H-1,2,3-triazol-4-yl)methyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one

Molbank, 2023
The new polyheterocyclic compound, 2-benzyl-7-(4-chlorophenyl)-3-morpholino-6-((1-phenyl-1H-1,2,3-triazol-4-yl)methyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one, was synthesized by a sequential combination of 4-chlorobenzaldehyde, (1-phenyl-1H-1,2,3 ...
Perla Islas-Jácome, Cecilia García-Falcón, Sandra L. Castañón-Alonso, Ernesto Calderón-Jaimes, Daniel Canseco-González, Alejandro Islas-Jácome, Eduardo González-Zamora   +6 more
doaj   +1 more source

Synthesis and Biological Evaluation of a Fused Structure of Indolizine and Pyrrolo[1,2-c]pyrimidine: Identification of Its Potent Anticancer Activity against Liver Cancer Cells

Pharmaceuticals, 2022
A highly efficient approach to a new indolizine scaffold fused with pyrrolo[1,2-c]pyrimidine was achieved via one-pot three-component coupling followed by an oxidative cyclization reaction.
Seonghyeon Nam, Yechan Lee, So-Hyeon Park, Wan Namkung, Ikyon Kim   +4 more
doaj   +1 more source

Synthesis of New bis-furanyl-pyrrolo[3,4-b]pyridin-5-ones via the Ugi-Zhu Reaction and Docking Studies on the Main Protease (M^Pro) from SARS-CoV-2

Chemistry Proceedings, 2021
The synthesis of five new bis-furanyl-pyrrolo[3,4-b]pyridin-5-ones in 30 to 40% yields through a domino sequence based on the Ugi-Zhu three-component reaction is described.
Ivette Morales-Salazar, Sandra L. Castañón-Alonso, Daniel Canseco-González, Erik Díaz-Cervantes, Eduardo González-Zamora, Alejandro Islas-Jácome   +5 more
doaj   +1 more source

Geometrically Compelled Silicon(II)/Silicon(IV) Donor–Acceptor Interaction Enables the Enamination of Nitriles

Angewandte Chemie, Volume 135, Issue 49, December 4, 2023., 2023
Hydrido‐benzosiloles bearing a side arm of the silylenyl group are prepared, all featuring the unique silicon(II)→silicon(IV) donor‐acceptor interaction that facilitates the enamination of α‐H‐bearing nitriles to afford the edge‐fused Si‐heterotricycles.
Deliang Kong, Jiancheng Li, Wen Dai, Liuying Jiang, Yiling Zhao, Hongping Zhu, Gang Fu, Herbert W. Roesky   +7 more
wiley   +2 more sources

Recent Applications of Quinolinium Salts in the Synthesis of Annulated Heterocycles

SynOpen, 2022
Quinoline derivatives are frequently found in natural products and biologically active compounds; however, construction of quinoline fused polyheterocycles is a challenging goal in synthetic organic chemistry.
Suven Das
doaj   +1 more source

Cp∗Rh/Ag catalyzed C–H activation/cyclization sequences of NH-sulfoximines to fused aza-polyheterocycles under gentle conditions

Green Synthesis and Catalysis, 2023
Disclosed herein is a novel Rh/Ag co-catalyzed SNH directed C–H activation and C–H/N–H bond functionalization protocol of free NH-sulfoximines with hypervalent iodonium ylides.
Jiapian Huang, Fei Liu, Feihua Du, Linghui Zeng, Zhiyuan Chen   +4 more
doaj   +1 more source