Synthesis and Conformational Analysis of Naphthoxazine-Fused Phenanthrene Derivatives
Molecules, 2020 The synthesis of new phenanthr[9,10-e][1,3]oxazines was achieved by the direct coupling of 9-phenanthrol with cyclic imines in the modified aza-Friedel–Crafts reaction followed by the ring closure of the resulting bifunctional aminophenanthrols with ...
Khadija Belasri +6 more
doaj +1 more source
Hetero-Diels–Alder reactions of hetaryl and aryl thioketones with acetylenic dienophiles [PDF]
, 2015 Selected hetaryl and aryl thioketones react with acetylenecarboxylates under thermal conditions in the presence of LiClO4 or, alternatively, under high-pressure conditions (5 kbar) at room temperature yielding thiopyran derivatives.
Grzelak, Paulina +4 more
core +4 more sources
Methanol as a C1 Source for the Synthesis of 1,3‐Polyheterocyclic Systems
European Journal of Organic Chemistry, Volume 26, Issue 48, December 19, 2023., 2023 A simple, efficient and low‐cost procedure for the synthesis of 1,3‐polyheterocyclic systems was reported, starting from the easily accessible aminoalcohols or diaminoalkanes, using CuCl2 as catalyst, H2O2, as inexpensive oxidant agent, and methanol acting both as solvent and reagent, proceeding under mild reaction conditions.
Letizia Molteni +4 more
wiley +1 more source
Fluorescent annulated imidazo[4,5-c]isoquinolines via a GBB-3CR/imidoylation sequence - DNA-interactions in pUC-19 gel electrophoresis mobility shift assay [PDF]
, 2022 Herein we report the development of a sequential synthesis route towards annulated imidazo[4,5-c]isoquinolines comprising a GBB-3CR, followed by an intramolecular imidoylative cyclisation.
Adam, C. R. +7 more
core +3 more sources
A Short Synthesis of (±)-3-Demethoxyerythratidinone by Ligand Controlled Selective Heck Cyclization of Equilibrating Enamines [PDF]
, 2017 A short, 5-step total synthesis of (±)-3-demethoxyerythratidinone from a simple pyrrole derivative is described. Features include the formation of gram quantities of a key tricylic aziridine from a challenging photochemical cascade reaction through the ...
Albini +39 more
core +2 more sources
A Zinc-Mediated Deprotective Annulation Approach to New Polycyclic Heterocycles [PDF]
, 2021 A straightforward approach to new polycyclic heterocycles, 1H-benzo[4,5]imidazo[1,2-c][1,3]oxazin-1-ones, is presented. It is based on the ZnCl2-promoted deprotective 6-endo-dig heterocyclization of N-Boc-2-alkynylbenzimidazoles under mild conditions ...
Bartolo Gabriele +6 more
core +1 more source
Dual-functionalization device for therapy through dopamine release and monitoring [PDF]
, 2018 "This is the pre-peer reviewed version of the following article: G. Fabregat, A. Giménez, A. Díaz, J. Puiggalí, C. Alemán, Macromol. Biosci. 2018, 18, 1800014 , which has been published in final form at https://doi.org/10.1002/mabi.201800014 .
Alemán Llansó, Carlos +4 more
core +2 more sources
Rhodacyclopentanones as Linchpins for the Atom Economical Assembly of Diverse Polyheterocycles [PDF]
, 2020 We outline a conceptual blueprint that provides direct and atom economical access to a wide range of complex polyheterocycles. Our method capitalizes on the ambiphilic reactivity of rhodacyclopentanones that arise upon exposure of cyclopropanes to Rh(I ...
Bertrand, Sophie M. +4 more
core +2 more sources
Chiral Sulfinamidourea and Strong Brønsted Acid–Cocatalyzed Enantioselective Povarov Reaction to Access Tetrahydroquinolines [PDF]
, 2014 This protocol describes a method for the laboratory synthesis of enantiomerically enriched, chiral tetrahydroisoquinolines through the application of a chiral sulfinamido urea catalyst for the Povarov reaction.
Jacobsen, Eric N., Xu, Hao, Zhang, Hu
core +1 more source
Iron-catalyzed cascade synthesis of nitrogen polycycles from alkynoic acids and functionalized amines [PDF]
, 2022 Catalysis by first-row transition metals is of increasing interest in the context of the scarcity of chemical resources. For instance, iron is promising due to its abundance, low toxicity and unique electronic features.
Astobieta, Elene +6 more
core +2 more sources