Results 21 to 30 of about 1,317 (206)

Pd-Catalyzed Asymmetric Allylic Substitution Cascade via Desymmetrization for the Construction of Chiral Polyheterocycles

Pharmaceutical Fronts
Chiral polyheterocycles represent an important class of compounds because of their prevalence in bioactive natural products and chiral drugs. Pd-catalyzed allylic substitution is a powerful synthetic tool for forming C–C and C–X bonds (X = N, O, S, etc.).
Xuezhen Kou, Yongjin Xu, Siqi Dong, Hui Liu, Delong Liu, Wanbin Zhang   +5 more
doaj   +2 more sources

Diverse Synthesis of Fused Polyheterocyclic Compounds via [3 + 2] Cycloaddition of In Situ-Generated Heteroaromatic N-Ylides and Electron-Deficient Olefins [PDF]

Molecules, 2023
[3 + 2] Cycloaddition reactions of heteroaromatic N-ylides with electron-deficient olefins have been developed. The heteroaromatic N-ylides, in situ generated from N-phenacylbenzothiazolium bromides, can smoothly react with maleimides under very mild ...
Zhen-Hua Wang, Tong Zhang, Li-Wen Shen, Xiu Yang, Yan-Ping Zhang, Yong You, Jian-Qiang Zhao, Wei-Cheng Yuan   +7 more
doaj   +2 more sources

Synthesis of polyheterocycles via multicomponent reactions.

Organic & Biomolecular Chemistry, 2018
Polyheterocycles are one of the most desired synthetic targets due to their numerous and valuable applications in various fields.
Ilich A. Ibarra, A. Islas‐Jácome, E. González‐Zamora   +2 more
semanticscholar   +3 more sources

A Brief Overview of Two Major Strategies in Diversity-Oriented Synthesis: Build/Couple/Pair and Ring-Distortion. [PDF]

Front Chem, 2018
In the interdisciplinary research field of chemical biology and drug discovery, diversity-oriented synthesis (DOS) has become indispensable in the construction of novel small-molecule libraries rich in skeletal and stereochemical diversity.
Yi S, Varun BV, Choi Y, Park SB.
europepmc   +3 more sources

2-Benzyl-7-(4-chlorophenyl)-3-morpholino-6-((1-phenyl-1H-1,2,3-triazol-4-yl)methyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one

Molbank, 2023
The new polyheterocyclic compound, 2-benzyl-7-(4-chlorophenyl)-3-morpholino-6-((1-phenyl-1H-1,2,3-triazol-4-yl)methyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one, was synthesized by a sequential combination of 4-chlorobenzaldehyde, (1-phenyl-1H-1,2,3 ...
Perla Islas-Jácome, Cecilia García-Falcón, Sandra L. Castañón-Alonso, Ernesto Calderón-Jaimes, Daniel Canseco-González, Alejandro Islas-Jácome, Eduardo González-Zamora   +6 more
doaj   +1 more source

Synthesis and Biological Evaluation of a Fused Structure of Indolizine and Pyrrolo[1,2-c]pyrimidine: Identification of Its Potent Anticancer Activity against Liver Cancer Cells

Pharmaceuticals, 2022
A highly efficient approach to a new indolizine scaffold fused with pyrrolo[1,2-c]pyrimidine was achieved via one-pot three-component coupling followed by an oxidative cyclization reaction.
Seonghyeon Nam, Yechan Lee, So-Hyeon Park, Wan Namkung, Ikyon Kim   +4 more
doaj   +1 more source

Synthesis of New bis-furanyl-pyrrolo[3,4-b]pyridin-5-ones via the Ugi-Zhu Reaction and Docking Studies on the Main Protease (M^Pro) from SARS-CoV-2

Chemistry Proceedings, 2021
The synthesis of five new bis-furanyl-pyrrolo[3,4-b]pyridin-5-ones in 30 to 40% yields through a domino sequence based on the Ugi-Zhu three-component reaction is described.
Ivette Morales-Salazar, Sandra L. Castañón-Alonso, Daniel Canseco-González, Erik Díaz-Cervantes, Eduardo González-Zamora, Alejandro Islas-Jácome   +5 more
doaj   +1 more source

Geometrically Compelled Silicon(II)/Silicon(IV) Donor–Acceptor Interaction Enables the Enamination of Nitriles

Angewandte Chemie, Volume 135, Issue 49, December 4, 2023., 2023
Hydrido‐benzosiloles bearing a side arm of the silylenyl group are prepared, all featuring the unique silicon(II)→silicon(IV) donor‐acceptor interaction that facilitates the enamination of α‐H‐bearing nitriles to afford the edge‐fused Si‐heterotricycles.
Deliang Kong, Jiancheng Li, Wen Dai, Liuying Jiang, Yiling Zhao, Hongping Zhu, Gang Fu, Herbert W. Roesky   +7 more
wiley   +2 more sources

6-Exo-dig cyclization/dearomatization cascade towards N-O fused spiro polyheterocycles

Organic Chemistry Frontiers, 2023
Herein, we present a metal-free cascade cyclization of alkyne-tethered N-alkoxybenzamides for the construction of structurally novel polyheterocycles.
Zhenwei Lv, Yan Li, E. V. Van der Eycken, Lingchao Cai, Liangliang Song   +4 more
semanticscholar   +1 more source

Recent Applications of Quinolinium Salts in the Synthesis of Annulated Heterocycles

SynOpen, 2022
Quinoline derivatives are frequently found in natural products and biologically active compounds; however, construction of quinoline fused polyheterocycles is a challenging goal in synthetic organic chemistry.
Suven Das
doaj   +1 more source