Bactericidal Effect and Mechanism of Polyhexamethylene Biguanide (PHMB) on Pathogenic Bacteria in Marine Aquaculture [PDF]
BiologyGuanidine disinfectants are cationic polymers recognized for their effective sterilization properties and their ability to prevent bacterial resistance.
Cuiping Ma, Meijie Liao, Xiaojun Rong
exaly +7 more sources
The Effects of Polyhexamethylene Biguanide (PHMB) and TLR Agonists Alone or as Polyplex Nanoparticles against Leishmania infantum Promastigotes and Amastigotes [PDF]
Veterinary Sciences, 2020 Dogs are the main reservoir for Leishmania infantum, manifesting from a subclinical to a fatal disease. Limited treatments are available, although new antiparasitics and immunomodulators are pursued.
Pamela Martínez-Orellana +3 more
doaj +9 more sources
Selection of a Gentamicin-Resistant Variant Following Polyhexamethylene Biguanide (PHMB) Exposure in Escherichia coli Biofilms [PDF]
Antibiotics, 2021 Antibiotic resistance is one of the most important issues facing modern medicine. Some biocides have demonstrated the potential of selecting resistance to antibiotics in bacteria, but data are still very scarce and it is important to better identify the ...
Clémence Cuzin +5 more
doaj +6 more sources
The Efficacy of Polyhexamethylene Biguanide (PHMB) with Negative Pressure Wound Therapy in Open Diabetic Foot Amputation [PDF]
Foot & Ankle OrthopaedicsCategory: Diabetes; Midfoot/Forefoot Introduction/Purpose: The therapeutic efficacy of negative pressure wound therapy (NPWT) in treating skin defects in diabetic foot ulcers has been demonstrated, although the management of bacterial biofilms remains ...
Jiyong Ahn MD, PhD +6 more
doaj +4 more sources
Fungal cell barriers and organelles are disrupted by polyhexamethylene biguanide (PHMB) [PDF]
Scientific Reports, 2023 The similarities between fungal and mammalian cells pose inherent challenges for the development of treatments for fungal infections, due to drug crossover recognition of host drug targets by antifungal agents.
Winnie Ntow-Boahene +3 more
doaj +4 more sources
Longitudinal Study on the Antimicrobial Performance of a Polyhexamethylene Biguanide (PHMB)-Treated Textile Fabric in a Hospital Environment [PDF]
Polymers, 2023 Healthcare workers in the hospital environment are at risk of infection and body fluids such as saliva, bacterial contamination, oral bacteria, etc. directly or indirectly exacerbate this issue. These bio-contaminants, when adhered to hospital linens and clothing, grow substantially, as conventional textile products provide a favorable medium for ...
Chi-Wai Kan
exaly +5 more sources
Polymers, 2023 The surface modification of cellulose nanofibers (CNFs) using a 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)/sodium bromide (NaBr)/sodium hypochlorite (NaClO) system was successful in improving their hydrophilicity. Following that, we fabricated hydrogels containing carboxylated cellulose nanofibers (c-CNFs) and loaded them with polyhexamethylene ...
Pornchai Rachtanapun +2 more
exaly +4 more sources
Three Consecutive Cases of Ocular Polyhexamethylene Biguanide (PHMB) Toxicity Due to Compounding Error. [PDF]
Cureus, 2023 Acanthamoeba keratitis is treated with long-term biguanide therapy, and the treatment itself can lead to ocular side effects. Knowledge of possible toxic complications can help in the better titration of the treatment regimen. Here, we describe the toxic side effects of polyhexamethylene biguanide (PHMB), which occurred in three consecutive patients ...
Patel NV +4 more
europepmc +3 more sources
Evaluation of polyhexamethylene biguanide (PHMB) as a disinfectant for adenovirus. [PDF]
JAMA Ophthalmol, 2013 Swimming pools can be a vector for transmission of adenovirus ocular infections. Polyhexamethylene biguanide (PHMB) is a disinfectant used in swimming pools and hot tubs.To determine whether PHMB is an effective disinfectant against ocular adenovirus serotypes at a concentration used to disinfect swimming pools and hot tubs.In vitro laboratory study ...
Romanowski EG +5 more
europepmc +4 more sources
Journal of Advanced Research, 2020 Acanthamoeba keratitis (AK) is difficult to treat, especially when the corneal deep stroma is involved. Intrastromal injection of antimicrobial agents is an effective adjuvant therapy for deep recalcitrant microbial keratitis; however, it has not been ...
Yi-Hsun Huang
exaly +3 more sources