Results 141 to 150 of about 42,850 (196)

Actinomycetota-Derived Metabolites in Pancreatic Cancer: Chemical Diversity, Metabolic Vulnerability, and Translational Barriers. [PDF]

Curr Oncol Rep
Lima DDSP, Silva MDS, Soares MDR, Lima Terceiro LE, de Lima NTR, de Oliveira GD, de Souza TA, Rodrigues-Junior VS, Cibulski SP.   +8 more
europepmc   +1 more source

Functional Role of AveC Residues Ser138 and Ala139 for Avermectin and Doramectin Biosynthesis in <i>Streptomyces avermitilis</i>. [PDF]

Metabolites
Li Z, Zhang L, Li X, Li M, Xia H.
europepmc   +1 more source

NRPS and PKS pathways in actinomycetes: A review of biosynthetic diversity and bioactive potential. [PDF]

Curr Res Pharmacol Drug Discov
Chauhan A, Gurnani M, Arora J, Chauhan R, Ranjan A, Chandra Joshi N, Dufossé L, Jindal T.   +7 more
europepmc   +1 more source

Secondary metabolite profiling of rare Micromonospora spp. from cold desert of NW Himalayas via multi-omics analysis. [PDF]

Metabolomics
Sharma N, Chander D, Hussain N, Chaubey A.   +3 more
europepmc   +1 more source

From diversity to function: microbiome-mediated plant growth promotion, secondary metabolism, and antimicrobial resistance in <i>Rauwolfia serpentina</i>. [PDF]

Front Bioinform
Bankar VR, Chapadgaonkar SS, Bhattacharyya K, K P.   +3 more
europepmc   +1 more source

Molecular networks and bioactivity-guided discovery of aliphatic derivatives from marine-derived fungus <i>Talaromyces</i> sp. [PDF]

RSC Adv
Ning Y, Qu Y, Zhou Y, Xu Y, Zhou X, Jiao B, Lu X.   +6 more
europepmc   +1 more source

The Stereochemistry of Complex Polyketide Biosynthesis by Modular Polyketide Synthases

Molecules, 2011
Polyketides are a diverse class of medically important natural products whose biosynthesis is catalysed by polyketide synthases (PKSs), in a fashion highly analogous to fatty acid biosynthesis. In modular PKSs, the polyketide chain is assembled by the successive condensation of activated carboxylic acid-derived units, where chain extension occurs with ...
David H Kwan, Frank Schulz
exaly   +7 more sources

Structural control of polyketide formation in plant-specific polyketide synthases [PDF]

Chemistry and Biology, 2000
Polyketide synthases (PKSs) generate molecular diversity by utilizing different starter molecules and by controlling the final length of the polyketide. Although exploitation of this mechanistic variability has produced novel polyketides, the structural foundation of this versatility is unclear. Plant-specific PKSs are essential for the biosynthesis of
Juan Ferrer, Joseph M. Jez, Joseph P Noel   +2 more
exaly   +5 more sources

A Polyketide Synthase Component for Oxygen Insertion into Polyketide Backbones [PDF]

Angewandte Chemie - International Edition, 2018
AbstractEnzymatic core components from trans‐acyltransferase polyketide synthases (trans‐AT PKSs) catalyze exceptionally diverse biosynthetic transformations to generate structurally complex bioactive compounds. Here we focus on a group of oxygenases identified in various trans‐AT PKS pathways, including those for pederin, oocydins, and toblerols ...
Eric J N Helfrich, Jörn Piel, Birgit Piechulla   +2 more
exaly   +6 more sources