Results 11 to 20 of about 15,017 (178)

Brincidofovir inhibits polyomavirus infection in vivo

mBio
Polyomaviruses are species-specific DNA viruses that can cause disease in immunocompromised individuals. Despite their role as the causative agents for several diseases, there are no currently approved antivirals for treating polyomavirus infection ...
Arrienne B. Butic, Zoe E. Katz, Ge Jin, Koji Fukushima, Masatoshi Hazama, Aron E. Lukacher, Matthew D. Lauver   +6 more
doaj   +3 more sources

Antibodies Can Extenuate Polyomavirus Infections. [PDF]

J Am Soc Nephrol, 2018
We read the article “Neutralizing antibody-mediated response and risk of BK virus–associated nephropathy” by Solis et al. [1][1] with great interest. Although a cell-mediated immune response is crucial for overcoming and clearing polyoma-BK virus infections and polyoma virus nephropathy ...
Nickeleit V, Singh HK, Rivier LH.
europepmc   +4 more sources

Microtubules in Polyomavirus Infection [PDF]

Viruses, 2020
Microtubules, part of the cytoskeleton, are indispensable for intracellular movement, cell division, and maintaining cell shape and polarity. In addition, microtubules play an important role in viral infection. In this review, we summarize the role of the microtubules’ network during polyomavirus infection.
Lenka Horníková, Kateřina Bruštíková, Jitka Forstová   +2 more
openaire   +3 more sources

Glucocorticoids Do Not Enhance BK Polyomavirus Replication in Human Renal Proximal Tubular Epithelial Cells In Vitro. [PDF]

Clin Transl Sci
ABSTRACT BK polyomavirus (BKPyV) infection may lead to BKPyV‐associated nephropathy (BKPyVAN) and subsequent graft loss in kidney transplant recipients. Experimental studies have suggested that glucocorticoids (GCs) may enhance BKPyV replication through a steroid‐responsive element within the viral genome.
Moest WT, Lalai RA, Prins J, de Vries APJ, Wessels E, van Kooten C, Feltkamp MCW, Rotmans JI.   +7 more
europepmc   +2 more sources

Histogenesis of Merkel Cell Carcinoma: A Comprehensive Review

Frontiers in Oncology, 2019
Merkel cell carcinoma (MCC) is a primary neuroendocrine carcinoma of the skin. This neoplasia features aggressive behavior, resulting in a 5-year overall survival rate of 40%. In 2008, Feng et al.
Thibault Kervarrec, Thibault Kervarrec, Thibault Kervarrec, Mahtab Samimi, Mahtab Samimi, Serge Guyétant, Serge Guyétant, Bhavishya Sarma, Jérémy Chéret, Emmanuelle Blanchard, Emmanuelle Blanchard, Patricia Berthon, David Schrama, Roland Houben, Antoine Touzé   +14 more
doaj   +1 more source

Phosphoinositide 3′-Kinase γ Facilitates Polyomavirus Infection

Viruses, 2020
Polyomaviruses are small, non-enveloped DNA tumor viruses that cause serious disease in immunosuppressed people, including progressive multifocal leukoencephalopathy (PML) in patients infected with JC polyomavirus, but the molecular events mediating ...
Paul Clark, Gretchen V. Gee, Brandon S. Albright, Benedetta Assetta, Ying Han, Walter J. Atwood, Daniel DiMaio   +6 more
doaj   +1 more source

Clinical and Epidemiologic Characterization of WU Polyomavirus Infection, St. Louis, Missouri

Emerging Infectious Diseases, 2007
WU polyomavirus is a recently described polyomavirus found in patients with respiratory infections. Of 2,637 respiratory samples tested in St. Louis, Missouri, 2.7% were positive for WU polyomavirus by PCR, and 71% were coinfected with other respiratory ...
Binh-Minh Le, Lee M. Demertzis, Guang Wu, Robert J. Tibbets, Richard S. Buller, Max Q. Arens, Anne M. Gaynor, Gregory A. Storch, David Wang   +8 more
doaj   +1 more source

The Role of Histone Post-Translational Modifications in Merkel Cell Carcinoma

Frontiers in Oncology, 2022
Merkel Cell Carcinoma (MCC) is a rare but highly aggressive form of non–melanoma skin cancer whose 5-year survival rate is 63%. Merkel cell polyomavirus (MCPyV), a small DNA tumor virus, is the etiological agent of MCC.
Chiara Mazziotta, Chiara Mazziotta, Carmen Lanzillotti, Carmen Lanzillotti, Roberta Gafà, Antoine Touzé, Marie-Alice Durand, Fernanda Martini, Fernanda Martini, Fernanda Martini, John Charles Rotondo, John Charles Rotondo   +11 more
doaj   +1 more source

BK Polyomavirus Infection and Renourinary Tumorigenesis [PDF]

American Journal of Transplantation, 2016
BK polyomavirus (BKPyV) infection represents a major problem in transplantation, particularly for renal recipients developing polyomavirus-associated nephropathy (PyVAN). The possibility that BKPyV may also be oncogenic is not routinely considered.
Papadimitriou, J. C., Randhawa, P., Rinaldo, C. H., Drachenberg, C. B., Alexiev, B., Hirsch, H. H.   +5 more
openaire   +4 more sources

JC Polyomavirus Infections in Transplant Patients [PDF]

Journal of Transplantation Technologies & Research, 2012
The polyomavirus JC virus (JCV) is a small nonenveloped DNA virus that asymptomatically infects about 80% of healthy adults and establishes latency in the kidney tissue. In case of immunodeficient hosts, JCV can lytically infect the oligodendrocytes, causing a fatal demyelinating disease, known as Progressive Multifocal Leukoencephalopathy (PML ...
S. Delbue, M. Ferraresso
openaire   +1 more source