Results 21 to 30 of about 14,466 (180)

The Role of Histone Post-Translational Modifications in Merkel Cell Carcinoma

Frontiers in Oncology, 2022
Merkel Cell Carcinoma (MCC) is a rare but highly aggressive form of non–melanoma skin cancer whose 5-year survival rate is 63%. Merkel cell polyomavirus (MCPyV), a small DNA tumor virus, is the etiological agent of MCC.
Chiara Mazziotta, Chiara Mazziotta, Carmen Lanzillotti, Carmen Lanzillotti, Roberta Gafà, Antoine Touzé, Marie-Alice Durand, Fernanda Martini, Fernanda Martini, Fernanda Martini, John Charles Rotondo, John Charles Rotondo   +11 more
doaj   +1 more source

Diagnostic Methods for and Clinical Pictures of Polyomavirus Primary Infections in Children, Finland

Emerging Infectious Diseases, 2014
We used comprehensive serodiagnostic methods (IgM, IgG, and IgG avidity) and PCR to study Merkel cell polyomavirus and trichodysplasia spinulosa-associated polyomavirus infections in children observed from infancy to adolescence. Comparing seroconversion
Tingting Chen, Laura Tanner, Ville Simell, Lea Hedman, Marjaana Mäkinen, Mohammadreza Sadeghi, Riitta Veijola, Heikki Hyöty, Jorma Ilonen, Mikael Knip, Jorma Toppari, Olli Simell, Maria Söderlund-Venermo, Klaus Hedman   +13 more
doaj   +1 more source

Economic Evaluation of Screening for Polyomavirus Infection in Kidney Transplant Recipients: A Cost-Utility Analysis

Transplantation Direct, 2022
Background:. Screening for polyomavirus infection after kidney transplantation is recommended by clinical practice guidelines, but cost-effectiveness of this strategy is uncertain.
Germaine Wong, PhD, Thida Maung Myint, MMed, Yoon Jae Lee, MD, Jonathan C. Craig, PhD,, David Axelrod, MD, MBA, Bryce Kiberd, MD   +5 more
doaj   +1 more source

Polyomavirus nephropathy: Risk analysis in paired renal Transplant recipients

Brazilian Journal of Transplantation, 2016
Polyomavirus allograft nephropathy (PVAN) has a negative impact on allograft function and survival. Analysis of paired kidneys from same donor can help to understand the role of recipient risk factors for PVAN. This analysis can also define donor related
André Barros Albuquerque Esteves, Luiz Roberto Sousa Ulisses, Leonardo Figueiredo Camargo, Gabriel Giollo Rivelli, Marcos Vinicius de Sousa, Marilda Mazzali   +5 more
doaj   +1 more source

Merkel Cell Polyomavirus Infection and Detection [PDF]

Journal of Visualized Experiments, 2019
Merkel cell polyomavirus (MCPyV) infection can lead to Merkel cell carcinoma (MCC), a highly aggressive form of skin cancer. Mechanistic studies to fully investigate MCPyV molecular biology and oncogenic mechanisms have been hampered by a lack of adequate cell culture models.
Wei, Liu, Nathan A, Krump, Christopher B, Buck, Jianxin, You   +3 more
openaire   +2 more sources

Polyomavirus infection in renal allograft

The Brazilian Journal of Infectious Diseases, 2013
A 32-year-old-man, an Alport Syndrome carrier X link genetic disorder,1 has developed renal insufficiency and has been on peritoneal dialysis for 10 months. In June/2011, he underwent a kidney (cadaver) transplantation with 3 panel mismatch, reactivity of lymphocytes Class I and II 0% and MIC-A negative.
Araújo, Stanley de Almeida, Honorato-Sampaio, Kinulpe, Fernandes Júnior, Ladislau José   +2 more
openaire   +5 more sources

Prevalence of cytomegalovirus and BK polyoma virus infection in post-renal transplant patients in a tertiary care centre in South India [PDF]

Journal of Nephropathology, 2017
Background: Viral infections are a significant cause of graft loss and dysfunction in kidney transplant recipients. Cytomegalovirus and BK polyomavirus have often been explained as the most common viral etiological agents.
Kevin Manuel, Marie Moses Ambroise, Renu G’Boy Varghese, Ilangovan Veerapan, Georgi Abraham   +4 more
doaj   +1 more source

Seroprevalence of Trichodysplasia Spinulosa–associated Polyomavirus

Emerging Infectious Diseases, 2011
We identified a new polyomavirus in skin lesions from a patient with trichodysplasia spinulosa (TS). Apart from TS being an extremely rare disease, little is known of its epidemiology.
Els van der Meijden, Siamaque Kazem, Manda M. Burgers, Rene Janssens, Jan Nico Bouwes Bavinck, Hester E. de Melker, Mariet C.W. Feltkamp   +6 more
doaj   +1 more source

JCPyV VP1 Mutations in Progressive Multifocal Leukoencephalopathy: Altering Tropism or Mediating Immune Evasion?

Viruses, 2020
Polyomaviruses are ubiquitous human pathogens that cause lifelong, asymptomatic infections in healthy individuals. Although these viruses are restrained by an intact immune system, immunocompromised individuals are at risk for developing severe diseases ...
Matthew D. Lauver, Aron E. Lukacher
doaj   +1 more source

Optimization of Adcitmer, a Monomethyl-Auristatin E bearing antibody-drug conjugate for the treatment of CD56-expressing cancers

Journal for ImmunoTherapy of Cancer
The cell adhesion protein CD56 has been identified as a potential therapeutic target in several solid tumors and hematological malignancies. Recently, we developed a CD56-directed antibody-drug conjugate (ADC), called Adcitmer and demonstrated its ...
David Schrama, Antoine Touze, Thibault Kervarrec, Mahtab Samimi, Valérie Gouilleux-Gruart, Aurelie Drouin, Laurine Durand, Clara Esnault, Pauline Gaboriaud, Valérie Leblond, Shawk Karim, Morgane Fouché, Christine Dhommée, Christine B Baltus, Fanny Boursin, Nicolas Aubrey, Roland Houben, Serge Guyétant, Audrey Desgranges, Marie Claude Viaud-Massuard   +19 more
doaj   +1 more source