Results 51 to 60 of about 15,017 (178)

Lanreotide, a Somatostatin Analogue, in Advanced Merkel Cell Carcinoma: A Prospective Single‐Arm Phase II Study

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Merkel Cell Carcinoma (MCC) is a rare, aggressive neuroendocrine and epithelial skin cancer. Somatostatin analogues, such as lanreotide, have shown efficacy in managing other neuroendocrine tumors. Retrospective studies suggest that lanreotide may induce partial response or disease stabilization in patients with advanced MCC.
Julie Charles, Aude Belbezier, Stéphane Mouret, Brigitte Dreno, Stéphane Dalle, Céleste Lebbe, Ewa Hainaut‐Wierzbicka, Andreea Stefan, Julie de Quatrebarbes, Olivier Dereure, Ouidad Zehou, Sandrine Mansard, Alain Dupuy, Caroline Dutriaux, Florent Grange, Caroline Gaudy‐Marqueste, Henri Montaudié, Jean‐Philippe Arnault, Yannick Le Corre, Thibault Kervarrec, Jean‐Louis Quesada, Mahtab Samimi, Marie‐Thérèse Leccia, The Group of Cutaneous Oncology of the French Society of Dermatology   +23 more
wiley   +1 more source

A case of acute kidney injury due to native kidney BK polyomavirus-associated nephropathy in a human T-lymphotropic virus type 1 carrier

BMC Nephrology, 2023
Background BK polyomavirus-associated nephropathy (BKPyVAN) has become a major cause of kidney dysfunction and graft loss in kidney transplant recipients.
Keita Takae, Yuki Ueno, Masumi Shojima, Hiroshi Nagae, Takako Nakano, Shohei Takata, Ritsuko Katafuchi, Kosuke Masutani, Toshiaki Nakano, Yusuke Kuroki   +9 more
doaj   +1 more source

Pathogenesis and Management of Polyomavirus Infection in Transplant Recipients [PDF]

Clinical Infectious Diseases, 2002
Polyomaviruses (JC virus [JCV], BK virus [BKV], and simian virus 40 [SV40]) establish subclinical and persistent infections and share the capacity for reactivation from latency in their host under immunosuppression. JCV establishes latency mainly in the kidney, and its reactivation results in the development of progressive multifocal ...
Eun Jeong, Kwak, Regis A, Vilchez, Parmjeet, Randhawa, Ron, Shapiro, Janet S, Butel, Shimon, Kusne   +5 more
openaire   +2 more sources

Cross‐Neutralizing and Broadly Neutralizing Human Antibodies Against Nonenveloped Viruses

European Journal of Immunology, Volume 56, Issue 10, October 2026.
In this review article, Marchand et al. compare cross ‐ and broadly ‐neutralizing human antibodies against non ‐ enveloped viruses from several major families, discussing their structural characteristics, neutralization mechanisms and relevance for the development of antiviral vaccines and therapeutics.
Sarah Marchand, Samy Taouli, Dorian McIlroy   +2 more
wiley   +1 more source

First Phylodynamic Analysis of HRSV‐A and HRSV‐B in Rio de Janeiro, Brazil, Reveals Recurrent Dispersals From the Megalopolis Center to Suburban Cities

Journal of Medical Virology, Volume 98, Issue 10, October 2026.
ABSTRACT Human respiratory syncytial virus (HRSV) is the leading cause of acute lower respiratory tract infections in infants and represents a major burden to public health systems worldwide. Despite its epidemiological relevance, genomic surveillance of HRSV in Brazil remains limited.
Alessandra Pavan Lamarca, Melise Chaves Silveira, Renata Campos Azevedo, Maria Angélica Arpon Marandino Guimarães, Claudia Maria Braga de Mello, Adriana Cardoso Camargo, Leandro Magalhães de Souza, Alexandra Lehmkuhl Gerber, Ana Paula C. Guimarães, Andréa Cony Cavalcanti, Ana Tereza Ribeiro Vasconcelos   +10 more
wiley   +1 more source

Polyomavirus – an emergent pathogen in transplant recipients [PDF]

Einstein (São Paulo), 2007
Medical centers that work with transplants often face opportunisticinfections that demand specific tools to make diagnosis. Theprevalence of latent polyomavirus infections is high, and the mostcommon site of latency of the most prevalent polyomavirus in ...
Juliana de Moura Montagner, Tatiana Ferreira Michelon, Regina Barbosa Schroeder, Bárbara Tengaten Fontanelle, Alexandre Tavares Duarte de Oliveira, Janaina Gomes da Silveira, Márcia Silveira Graudenz, Cláudio Osmar Pereira Alexandre, Jorge Neumann   +8 more
doaj  

Belatacept Conversion in Simultaneous Pancreas‐Kidney and Liver‐Kidney Transplant Recipients: A Single‐Center Feasibility Cohort and Narrative Review

Clinical Transplantation, Volume 40, Issue 10, October 2026.
ABSTRACT Background Calcineurin inhibitor (CNI) nephrotoxicity drives long‐term kidney‐function decline after simultaneous pancreas‐kidney (SPK) and liver‐kidney (LK) transplantation, but belatacept conversion, as an alternative strategy, is poorly studied in these recipients, whose non‐kidney allograft rejection risk differs.
Dusan Harmacek, Elena Rho, Seraina von Moos, Severin Simmler, Thomas Welte, Fabian Rössler, Thomas Schachtner, Lukas Weidmann   +7 more
wiley   +1 more source

Native BK Polyomavirus Nephropathy in an Orthotopic Heart Transplant Patient

Journal of Investigative Medicine High Impact Case Reports, 2023
BK polyomavirus nephropathy (BKVN) is a common cause of nephropathy in kidney transplant patients and is typically seen within the first year after transplantation.
Zachary M. Thompson MD, George Ajene DO, Prathit A. Kulkarni MD, Nidhi Aggarwal MD, Savitri Fedson MD, Maulin K. Shah MD   +5 more
doaj   +1 more source

Entering the Age of Specificity in T Cell Immunity

Immunological Reviews, Volume 343, Issue 1, October 2026.
ABSTRACT The discovery of MHC restriction, the resolution of peptide–MHC structure, and the identification of the T cell receptor gene quickly centered epitope‐level specificity as a core concern of T cell biology. Epitope mapping culminated in functional peptide‐based stimulation assays and tetramer staining, which together provide exquisite ...
Paul G. Thomas
wiley   +1 more source

The Significance of cGAS‐STING Signaling in Response to Oncogenic Viruses

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT The cyclic GMP‐AMP synthase (cGAS)‐stimulator of interferon genes (STING) signaling pathway, as a key DNA sensor, plays a significant role in the regulation of innate immune responses. This pathway can be activated by sensing abnormal DNA, and is of great significance for resisting the invasion of pathogenic microorganisms and maintaining ...
Limei Guo, Li Li, Fang Wang, Wen Liu, Yan Zhang   +4 more
wiley   +1 more source