Results 11 to 20 of about 1,853 (164)

Analysis of the structural correlates for antibody polyreactivity by multiple reassortments of chimeric human immunoglobulin heavy and light chain V segments. [PDF]

The Journal of experimental medicine, 1994
Polyreactive antibodies (Abs) constitute a major proportion of the early Ab repertoire and are an important component of the natural defense mechanisms against infections. They are primarily immunoglobulin M (IgM) and bind a variety of structurally dissimilar self and exogenous antigens (Ags) with moderate affinity.
Ichiyoshi, Y, Casali, P
openaire   +7 more sources

Antibody Polyreactivity: A Challenger of Immune Paradigms. [PDF]

Immunology
This review article discusses the definition and functions of polyreactive antibodies, as well as their physiological roles. It also presents the concept of polyreactivity as a challenger of immunological dogmas. ABSTRACT Polyreactivity refers to the ability of antibodies to bind multiple unrelated antigens, encompassing polyspecificity and promiscuity.
Pashov AD, Dimitrov JD.
europepmc   +2 more sources

Estrogen Modulation of B Cell Immunity: Implications for HIV Control and Therapeutic Strategies. [PDF]

Compr Physiol
Estrogen significantly modulates B‐cell immunity. We provide evidence for estrogen–B‐cell crosstalk (the estrogen–B‐cell axis) in regulating B‐cell function and shaping HIV acquisition, progression, and persistence, and highlight research gaps to guide hormone‐aware vaccines and therapies.
Kasibante J, Brown TT, Lake JE, Abdel-Mohsen M.   +3 more
europepmc   +2 more sources

Quantification of polyreactive immunoglobulin G facilitates the diagnosis of autoimmune hepatitis [PDF]

Hepatology, 2021
Abstract Background and Aims Detection of autoantibodies is a mainstay of diagnosing autoimmune hepatitis (AIH). However, conventional autoantibodies for the workup of AIH lack either sensitivity or specificity, leading to substantial diagnostic uncertainty.
Taubert, Richard, Engel, Bastian, Diestelhorst, Jana, Hupa-Breier, Katharina, Behrendt, Patrick, Baerlecken, Niklas, Sühs, Kurt‐wolfram, Janik, Maciej, Zachou, Kalliopi, Sebode, Marcial, Schramm, Christoph, Londoño, María‐carlota, Habes, Sarah, Oo, Ye, Lalanne, Claudine, Pape, Simon, Schubert, Maren, Hust, Michael, Dübel, Stefan, Thevis, Mario, Jonigk, Danny, Beimdiek, Julia, Buettner, Falk, Drenth, Joost, Muratori, Luigi, Adams, David, Dyson, Jessica, Renand, Amédée, Graupera, Isabel, Lohse, Ansgar, Dalekos, George, Milkiewicz, Piotr, Stangel, Martin, Maasoumy, Benjamin, Witte, Torsten, Wedemeyer, Heiner, Manns, Michael, Jaeckel, Elmar   +37 more
openaire   +10 more sources

Plasma-Derived Polyreactive Secretory-Like IgA and IgM Opsonizing Salmonella enterica Typhimurium Reduces Invasion and Gut Tissue Inflammation through Agglutination. [PDF]

, 2017
Due to the increasing emergence of antibiotic-resistant strains of enteropathogenic bacteria, development of alternative treatments to fight against gut infections is a major health issue.
Andersen, Azman, Berdoz, Both, Brandtzaeg, Brandtzaeg, Brandtzaeg, Casadevall, Corthésy, Corthésy, Corthésy, Cramer, Crottet, Czerkinsky, Dolowschiak, Elkon, Gorrell, Hiatt, Hoiseth, Jones, Juarez, Kadaoui, Liang, Longet, Longet, Maillet, Mathias, Mathias, Mestecky, Mestecky, Michetti, Mikulic, Mowat, Newburg, Pabst, Paul, Payne, Phalipon, Phalipon, Pigny, Pulickal, Rapaka, Rey, Rindisbacher, Virdi, Wagner, Zeitlin, Zhou, Zinkernagel   +48 more
core   +7 more sources

Alpha-Synuclein-Specific Naturally Occurring Antibodies Inhibit Aggregation In Vitro and In Vivo

Biomolecules, 2022
Parkinson’s disease (PD) is associated with motor and non-motor symptoms and characterized by aggregates of alpha-synuclein (αSyn). Naturally occurring antibodies (nAbs) are part of the innate immune system, produced without prior contact to their ...
Anne K. Braczynski, Marc Sevenich, Ian Gering, Tatsiana Kupreichyk, Emil D. Agerschou, Yannick Kronimus, Pardes Habib, Matthias Stoldt, Dieter Willbold, Jörg B. Schulz, Jan-Philipp Bach, Björn H. Falkenburger, Wolfgang Hoyer   +12 more
doaj   +1 more source

Effect of trifluoroethanol on antibody reactivity against corresponding and nonrelated antigens [PDF]

The Ukrainian Biochemical Journal, 2018
The ability of antibodies to switch between specific and nonspecific recognition of antigens under various factors is the key issue. Here we demonstrate that 2,2,2-trifluoroethanol (TFE) is one of these factors influencing the ability of monoclonal ...
S. A. Bobrovnik, M. O. Demchenko, S. V. Komisarenko   +2 more
doaj   +1 more source

Gastric MALT lymphoma B cells express polyreactive, somatically mutated immunoglobulins [PDF]

Blood, 2010
Abstract Gastric B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) arises against a background of chronic inflammation caused by persistent Helicobacter pylori infection. The clinical and histopathologic features of the human tumor can be reproduced by Helicobacter infection of BALB/c mice.
Craig, V J, Arnold, I, Gerke, C, Huynh, M Q, Wundisch, T, Neubauer, A, Renner, C, Falkow, S, Müller, Anne   +8 more
openaire   +2 more sources

Inventive activity of the Department of Molecular Immunology of the Palladin Institute of Biochemistry of NAS of Ukraine [PDF]

The Ukrainian Biochemical Journal, 2016
The article is devoted to the inventive activity of the Department of Molecular Immunology of the Palladin Institute of Biochemistry of NAS of Ukraine in the context of the history of its inception, development and in the context of scholarly and ...
V. M. Danilova, R. P. Vynogradova, S. G. Torkhova   +2 more
doaj   +1 more source

Natural anti-CCR5 antibodies in HIV-infection and -exposure [PDF]

, 2010
Natural antibodies constitute a first-line of defence against pathogens; they may also play other roles in immune regulation and homeostasis, through their ability to bind host antigens, surface molecules and receptors.
Lucia Lopalco
core   +1 more source