Natural polyreactive immunoglobulin A antibodies produced in mouse Peyer’s patches
Immunology, 1999 To understand the biological function of natural immunoglobulin A (IgA) antibodies in Peyer's patches (PP), we generated IgA monoclonal antibody (mAb) clones from the PP of normal, unimmunized, specific pathogen-free BALB/c mice and examined their reactivities by enzyme-linked immunosorbent assay (ELISA). Many of these antibodies reacted with more than
M, Shimoda, Y, Inoue, N, Azuma, C, Kanno
openaire +3 more sources
Gastric LTi cells promote lymphoid follicle formation but are limited by IRAK-M and do not alter microbial growth. [PDF]
, 2015 Lymphoid tissue inducer (LTi) cells are activated by accessory cell IL-23, and promote lymphoid tissue genesis and antibacterial peptide production by the mucosal epithelium.
Banerjee, A +9 more
core +2 more sources
Natural polyreactive secretory immunoglobulin A autoantibodies as a possible barrier to infection in humans [PDF]
Infection and Immunity, 1997 Secretory immunoglobulin A (S-IgA) was investigated in human secretions for the presence of natural antibodies (Abs) acting as the first "immune barrier" to infection before induction or boosting of specific responses. These molecules could be the secretory counterpart of the natural Abs in serum that were previously shown by our laboratory to be ...
C P, Quan +4 more
openaire +2 more sources
Avian Resistance to Campylobacter jejuni Colonization Is Associated with an Intestinal Immunogene Expression Signature Identified by mRNA Sequencing [PDF]
, 2012 peer-reviewedThis research was funded by the The Irish Department of Agriculture and Food’s Food Institutional Research Measure (http://www.agriculture.gov.ie/ research/foodinstitutionalresearchmeasurefirm) – Grant No: 06_RDD_486.Campylobacter jejuni is
Allan, Brenda +8 more
core +3 more sources
B-cell dysregulation in Crohn's disease is partially restored with infliximab therapy [PDF]
, 2016 Background: B-cell depletion can improve a variety of chronic inflammatory diseases, but does not appear beneficial for patients with Crohn's disease. Objective: To elucidate the involvement of B cells in Crohn's disease, we here performed an 'in depth ...
Bartol, S.J.W. (Sophinus) +10 more
core +1 more source
Polyreactive Autoantibodies Purified from Human Intravenous Immunoglobulins Prevent the Development of Experimental Autoimmune Diseases [PDF]
Laboratory Investigation, 2003 Intravenous immunoglobulins (IVIg) are therapeutic preparations of normal human polyclonal Ig G (IgG) that exert immunomodulatory effects in patients with autoimmune or systemic inflammatory diseases. Two different IgG subfractions were evaluated for their respective immunomodulatory effects in the treatment of experimental autoimmune diseases: a ...
Martine, Bruley-Rosset +5 more
openaire +2 more sources
Immunodeficiency in Bloom’s Syndrome [PDF]
, 2017 Bloom’s syndrome (BS) is an autosomal recessive disease, caused by mutations in the BLM gene. This gene codes for BLM protein, which is a helicase involved in DNA repair.
Deuren, M. (Marcel) van +8 more
core +1 more source
Rheumatoid factor: a novel determiner in cancer history [PDF]
, 2021 The possible interplay between autoimmunity and cancer is a topic that still needs to be deeply explored. Rheumatoid factors are autoantibodies that are able to bind the constant regions (Fc) of immunoglobulins class G (IgGs). In physiological conditions,
Nuti M., Ugolini A.
core +1 more source
Evidence for somatic selection of natural autoantibodies. [PDF]
, 1992 Natural autoantibodies are primarily immunoglobulin M (IgM) antibodies that bind to a variety of self-antigens, including self-IgG. Accounting for a large proportion of the early B cell repertoire, such polyspecific autoantibodies are speculated to ...
Carson, DA +3 more
core
Essential Role of NK Cells in IgG Therapy for Experimental Autoimmune Encephalomyelitis [PDF]
, 2013 published_or_final_versio
Chong, WP +4 more
core +1 more source