Results 21 to 30 of about 6,865 (203)

Ischemic Postconditioning Protects Aged Myocardium Against Ischemia/Reperfusion Injury by Regulating Mitochondrial Dynamics via piR-4913. [PDF]

Adv Sci (Weinh)
A tiny RNA tips the scales of cardiac injury in aging. piR‐4913 recruits OGT to Drp1 and drives its O‐GlcNAcylation at Thr604, promoting excessive mitochondrial fission that aggravates ischemia‐reperfusion injury. Ischemic postconditioning silences this pathway to restore mitochondrial balance and protect the aged myocardium, revealing piR‐4913 as a ...
Zhao X, Li Y, Li N, Zhang J, Ma X, Yang F, Long R, Tian Y, Wang Y, Ma S, Zhang H, Jiang Y.   +11 more
europepmc   +2 more sources

Targeting STAT3 to Modulate the Effectiveness of Cardioprotective Conditioning Strategies Against Myocardial Ischemia-Reperfusion Injury in Subjects With Diabetic Cardiomyopathy. [PDF]

J Cell Mol Med
ABSTRACT Myocardial ischemia–reperfusion injury (MIRI) is a major cause of cardiovascular morbidity and mortality. Reperfusion, although essential for myocardial restoration, can paradoxically exacerbate injury through oxidative stress, calcium overload, mitochondrial permeability transition pore opening and inflammatory infiltration. The vulnerability
Wang C, Tian W, Saedi S, Cui H, Liu D, Chu Q, Yang D, Xia Z.   +7 more
europepmc   +2 more sources

TRF2 Recovers Ischemic Postconditioning Cardioprotection in Aged Myocardiocytes by Regulating CSNK2A2 Localization and FUNDC1 Dephosphorylation. [PDF]

Aging Cell
Myocardial expression of telomeric repeat‐binding factor 2 (TRF2) was reduced in aged male mice and further downregulated following ischemic postconditioning (I/Post). Mechanistically, TRF2 confers cardioprotection by interacting with casein kinase 2 alpha 2 polypeptide (CSNK2A2) to modulate FUN14 domain‐containing protein 1 (FUNDC1) dephosphorylation,
Zhang X, Ma J, Shu R, Li Y, Zheng Y, Yin Y.   +5 more
europepmc   +2 more sources

Could limb laterality influence the efficacy of remote postischemic conditioning after stroke? [PDF]

Neuroprotection
Neuroprotection, Volume 4, Issue 3, Page 195-198, September 2026.
Chen H, Steinberg GK.
europepmc   +2 more sources

Cardiac Postconditioning [PDF]

Antioxidants & Redox Signaling, 2011
In the heart, ischemia/reperfusion damage occurs mainly during the first minutes of reperfusion. Recently, it has been shown that the heart can be protected against the extension of ischemia/reperfusion injury if brief coronary occlusions are performed just at the beginning of the reperfusion. This procedure has been called postconditioning (PostC). It
PAGLIARO, Pasquale, PENNA, Claudia
openaire   +3 more sources

Postconditioning [PDF]

Circulation, 2005
“From bench to bedside” is a favorite aphorism for the scientifically inclined cardiologist. When the powerful antiischemic effects of preconditioning were discovered in 1996, it was a revolutionary concept: Repetitive brief ischemia could beget protection instead of the logically anticipated increased myocardial damage.
Jakob Vinten-Johansen, Derek M. Yellon, Lionel H. Opie   +2 more
openaire   +1 more source

Molecular mechanism of ischemic postconditioning in promoting diabetic ischemic brain injury repair via the microRNA-34a-BDNF-SIX3 signaling axis. [PDF]

Animal Model Exp Med
Diabetes combined with ischemic stroke (DMIS) exacerbates brain infarct size and neuronal damage compared to nondiabetic ischemic stroke (IS). This study reveals that microRNA‐34a (miR‐34a) plays a key role in DMIS pathogenesis: miR‐34a directly targets and suppresses brain‐derived neurotrophic factor (BDNF) and Sine oculis homeobox 3 (SIX3), promoting
Zhao L, Zou C, Li J, Yang Y, Han Y, Ke T.   +5 more
europepmc   +2 more sources

Quercetin in Myocardial Ischemia–Reperfusion Injury: Mechanistic Evidence, Cardioprotective Effects, and Translational Challenges [PDF]

J Biochem Mol Toxicol
Quercetin mitigates myocardial ischemia–reperfusion injury through coordinated antioxidant, anti‐inflammatory, and anti‐apoptotic mechanisms, leading to reduced infarct size and improved cardiac function. Its multi‐target cardioprotective effects highlight quercetin as a promising therapeutic candidate for ischemic heart disease.
Syahputra R, Halim P, Hasibuan S, Lubis A.   +3 more
europepmc   +2 more sources

Sevoflurane Postconditioning Attenuates Hepatic Ischemia-Reperfusion Injury by Limiting HMGB1/TLR4/NF-κB Pathway via Modulating microRNA-142 in vivo and in vitro

Frontiers in Pharmacology, 2021
Preconditioning of sevoflurane (Sevo) has been demonstrated to protect the liver from ischemia/reperfusion (I/R) injury. However, it is unknown whether it has hepatoprotective when given at the onset of reperfusion (postconditioning), a protocol with ...
Liying Xu, Feng Ge, Yan Hu, Ying Yu, Kefang Guo, Changhong Miao   +5 more
doaj   +1 more source

nNOS and p-ERK involvement in the neuroprotection exerted by remote postconditioning in rats subjected to transient middle cerebral artery occlusion

Neurobiology of Disease, 2013
It has recently been hypothesized that a sub-lethal ischemic insult induced in one organ is able to protect from a harmful ischemia occurring in a different organ.
Giuseppe Pignataro, Elga Esposito, Rossana Sirabella, Antonio Vinciguerra, Ornella Cuomo, Gianfranco Di Renzo, Lucio Annunziato   +6 more
doaj   +1 more source