Results 41 to 50 of about 10,304,482 (352)
Molecular Brain, 2021 The SH3 and multiple ankyrin repeat domains 3 (Shank3) protein is a core organizer of the macromolecular complex in excitatory postsynapses, and its defects cause numerous synaptopathies, including autism spectrum disorders.
Chunmei Jin +13 more
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Preparation of Pre- and Post-synaptic Density Fraction from Mouse Cortex
Bio-Protocol, 2013 The understanding of the organization of postsynaptic signaling systems at excitatory synapses has been aided by the identification of proteins in the postsynaptic density (PSD) fraction, a subcellular fraction enriched in structures with the morphology ...
Chengyong Shen, Yong-Jun Chen
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Frontiers in Cellular Neuroscience, 2020 Non-evoked miniature release of neurotransmitters is increasingly recognized as playing an important role in neural function and is implicated in synaptic plasticity, metaplasticity, and homeostasis.
Henry B. C. Taylor +4 more
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Random Walks for Spike-Timing Dependent Plasticity [PDF]
, 2003 Random walk methods are used to calculate the moments of negative image equilibrium distributions in synaptic weight dynamics governed by spike-timing dependent plasticity (STDP). The neural architecture of the model is based on the electrosensory lateral line lobe (ELL) of mormyrid electric fish, which forms a negative image of the reafferent signal ...
arxiv +1 more source
Targeting the post-synaptic proteome has therapeutic potential for psychosis in Alzheimer Disease
Communications Biology, 2023 Individuals with Alzheimer Disease who develop psychotic symptoms (AD + P) experience more rapid cognitive decline and have reduced indices of synaptic integrity relative to those without psychosis (AD-P).
J. M. Krivinko +9 more
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Network algorithmics and the emergence of the cortical synaptic-weight distribution [PDF]
Physical Review E 81 (2010), 021916, 2009 When a neuron fires and the resulting action potential travels down its axon toward other neurons' dendrites, the effect on each of those neurons is mediated by the weight of the synapse that separates it from the firing neuron. This weight, in turn, is affected by the postsynaptic neuron's response through a mechanism that is thought to underlie ...
arxiv +1 more source
Frontiers in Neural Circuits, 2014 Glycinergic inhibition plays a central role in the auditory brainstem circuitries involved in sound localization and in the encoding of temporal action potential firing patterns.
Lina eYassin +6 more
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eLife, 2020 In the cerebellar cortex, molecular layer interneurons use chemical and electrical synapses to form subnetworks that fine-tune the spiking output of the cerebellum.
Andreas Hoehne +2 more
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Cortical Excitability Before and After Long‐Term Perampanel Treatment for Epilepsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Antiseizure medications (ASMs), which may influence cortical excitability, are the mainstay of epilepsy treatment. Transcranial magnetic stimulation (TMS) helps evaluate cortical excitability. We assessed changes in TMS responses using serial TMS measurements in people treated with an adjunctive noncompetitive AMPA‐receptor ...
Robert M. Helling +6 more
wiley +1 more source
Postsynaptic neuronal activity promotes regeneration of retinal axons
Cell Reports, 2023 Summary: The wiring of visual circuits requires that retinal neurons functionally connect to specific brain targets, a process that involves activity-dependent signaling between retinal axons and their postsynaptic targets.
Supraja G. Varadarajan +5 more
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