Results 71 to 80 of about 3,196 (289)
Synthesis of 3- 4-Acyl-2-(1-Methoxy-1-Methylethyl)Morpholin-3-Yl - Benzonitriles as Novel Potassium Channel Openers [PDF]
, 2009 Potassium channel openers (KCO's) have been demonstrated to possess potent relaxant-activity on smooth muscle. Tissue- selective KCO's may find use in the treatment of a variety of diseases, such as hypertension, asthma, and urinary incontinence. We have
林美香;忻凌偉;程正禹 +1 more
core
Mitochondrial BK Channel Openers CGS7181 and CGS7184 Exhibit Cytotoxic Properties [PDF]
, 2018 Potassium channel openers (KCOs) have been shown to play a role in cytoprotection through the activation of mitochondrial potassium channels. Recently, in several reports, a number of data has been described as off-target actions for KCOs. In the present
Adam Szewczyk +5 more
core +1 more source
Preconditioning with associated blocking of Ca2+ inflow alleviates hypoxia-induced damage to pancreatic β-cells. [PDF]
PLoS ONE, 2013 Beta cells of pancreatic islets are susceptible to functional deficits and damage by hypoxia. Here we aimed to characterize such effects and to test for and pharmacological means to alleviate a negative impact of hypoxia.Rat and human pancreatic islets ...
Zuheng Ma +6 more
doaj +1 more source
Magnesium‐Based Transient Bioelectronics, Bio‐Optics and Bio‐Scaffolds
Advanced Functional Materials, EarlyView.This paper reviews the state of the art and recent advances in magnesium‐based thin‐film, foils, and scaffolds for applications in transient bio‐optics, bioelectronics and tissue engineering. The design principles, fabrication methods, material properties, and integration strategies are discussed in detail.
Massimo Mariello, Yves Leterrier
wiley +1 more source
Frontiers in Molecular BiosciencesChronic heart failure (HF) is a common and frequently occurring disease worldwide, and its traditional treatment methods are undergoing earth-shaking changes.
Xiang Li, Suwen Bai, Yumei Luo
doaj +1 more source
Potassium channel opening: a subtle two‐step
The Journal of Physiology, 2009 Voltage‐gated K+ channels undergo a voltage‐dependent conductance change that plays a key role in modulating cellular excitability. While the Open state is captured in crystal structures of Kv1.2 and a chimeric Kv1.2/Kv2.1 channel, the Close state and the mechanism of this transition are still a subject of debate.
Sanjeev K, Upadhyay +2 more
openaire +3 more sources
Advanced Functional Materials, EarlyView.The intrinsic distortion‐rich lattice of HEPBA with GQD‐enabled microstrain engineering establishes a mechanistic route toward high‐performance alkaline hydrogen evolution reaction. HEPBA inherently feature heterogeneous local coordination environments arising from multimetal incorporation, while properly introducing GQD during coprecipitation ...
Mia Rinawati +10 more
wiley +1 more source
Two different types of channels are targets for potassium channel openers in Xenopus oocytes [PDF]
, 1991 K+ channel openers elicit K+ currents in follicle-enclosed Xenopus oocytes. The most potent activators are the pinacidil derivatives P1075 and P1060. The rank order of potency to activate K+ currents in follicle-enclosed oocytes was: P1075 (K0.5: 5 μM ...
Lazdunski, Michel +3 more
core +1 more source
Ionic Precursors Transformed Into Vinyl Acetate Synthesis Catalyst via Reaction‐Driven Restructuring
Advanced Functional Materials, EarlyView.This work demonstrates that a simple physical mixture of Pd and Au ionic precursors, KOAc promoter, and SiO2 support can transform into a highly active vinyl acetate synthesis catalyst through reaction‐driven restructuring. The results highlight reaction‐induced restructuring as an innovative and sustainable catalyst design strategy.
Byeong Jun Cha +11 more
wiley +1 more source
Effects of potassium channel openers on Na+ and K+ currents in rabbit sinus node and atrial myocytes [PDF]
, 1995 The effects of the potassium channel openers (KCOs) Cromakalim and Lemakalim on rabbit sinoatrial and atrial myocytes were examined by means of the whole-cell patch-clamp technique.
Tromba, Cinzia +3 more
core +1 more source