Results 71 to 80 of about 1,524,654 (239)

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature. [PDF]

, 2005
BACKGROUND: Electrophysiological data suggest that cardiac KATP channels consist of Kir6.2 and SUR2A subunits, but the distribution of these (and other KATP channel subunits) is poorly defined.
Artman, M, Alison Morrissey, Tomoe Y Nakamura, Yoshida, H, Parachuru, L, Nakamura, TY, Coetzee, WA, Lavanya Parachuru, Hidetada Yoshida, Andrew Tinker, Lanning, J, Gwendolyn Lopez, Morrissey, A, Michael Artman, William A Coetzee, Lopez, G, Tong, X, Dhar Chowdhury, P, XiaoYong Tong, Han, S, Jonathan P Giblin, Sandra Han, Giblin, JP, Erika Rosner, Jennifer Lanning, Piyali Dhar Chowdhury, Tinker, A, Rosner, E   +27 more
core   +1 more source

Bioinspired Hydrogels with Broadly Programmable Mechanics for Soft‐Tissue Interfaces

Advanced Functional Materials, EarlyView.
Sea cucumber‐inspired gelatin hydrogels are formed by directional freezing and mechanically programmed through subsequent ionic treatment. Multiscale characterization and modeling link ion‐regulated chain interactions to directional load transfer within the aligned hierarchical architecture.
Youchao Teng, TzuChun Chung, Katpady Akhil Tantry, Siyu Wu, Jing Tian, Yunqi Cui, Lanyu Li, Yongzan Zhou, Zhilei Zhang, Zhe Su, Gaili Cao, Kun‐Wei Yeh, Ruipeng Li, Xianghui Xiao, Adam F. G. Leontowich, Yuan‐Yu Hsueh, Zhao Pan, Kam C. Tam, Badri Narayanan, Song Li, Yimin. A. Wu   +20 more
wiley   +1 more source

Hypotonic Stress Increases Efficacy of Rilmakalim, but Not Pinacidil, to Activate ATP-Sensitive K+ Current in Guinea Pig Ventricular Myocytes

Journal of Pharmacological Sciences, 2004
The aim of this study was to investigate the influence of hypotonic challenge on the effects of potassium channel openers (PCO), rilmakalim and pinacidil, on activation of the ATP-sensitive K+ current.
Ivan Kocić, Yuji Hirano, Masayasu Hiraoka   +2 more
doaj   +1 more source

New uses potassium channel openers, such as the treatment of epilepsy

, 2001
New uses of retigabine and other potassium channel ...
Brian Cox (4465927), Stephen Anthony Burbidge (16207031), Russell Michael Hagan (16207040), Jeffrey John Clare (16207034), Joseph Dupere (16207037), Xinmin Xie (375146), Glaxo Group Limited (16207043)   +6 more
core  

Additively Manufactured Geometry‐Reconfigurable Soft Neural Probes With Monolithic Multifunctionality

Advanced Functional Materials, EarlyView.
A geometry‐reconfigured additive manufacturing strategy converts planar printed soft materials into soft compact neural probes with integrated hydrogel electrodes and microfluidic channels. The resulting NeuroMAP platform enables scalable multichannel recording, localized chemical delivery, stable in vivo electrophysiological recording, and reduced ...
Hyunjin Lee, Xinyi Wang, Sirui Li, Jihyang Park, Hyunseok Lee, Jianting Yao, Kedar Narayan, Yuqi Wang, Jiashu Ren, Yueqi Deng, Salahuddin Ahmed, Denver I. Greenawalt, Archana Pandiyan, Loganathan Veeramuthu, Chi‐Ching Kuo, Tao Zhou   +15 more
wiley   +1 more source

KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel α-subunit composition [PDF]

, 2011
Voltage-gated potassium (Kv) currents generated by N-type α-subunit homotetramers inactivate rapidly because an N-terminal ball domain blocks the channel pore after activation.
Abbott, G., Xu, Xianghua, Geoffrey W. Abbott, Kanda, Vikram A, Abbott, Geoffrey W, Anthony Lewis, Vikram A. Kanda, Xianghua Xu, Lewis, Anthony, Xianghua, X., Kanda, V.   +10 more
core   +1 more source

Bio‐Inspired Multifunctional Superhydrophilic Coatings With Remarkably Fast Self‐Healing Abilities

Advanced Functional Materials, EarlyView.
We developed bio‐inspired multifunctional hydrogel‐based coatings that exhibit extremely fast/repeatable self‐healing abilities, long‐lasting anti‐fogging performance, superhydrophilicity in air, and underwater superoleophobicity. By doping multivalent metal‐ions into the hydrogel networks, which promoted hydrogen bonding formation and enhanced the ...
Hyeonjin Kim, Jerred Wassgren, Hiroshi Kakiuchida, Kouki Akaike, Shunsuke Tanaka, Atsushi Hozumi   +5 more
wiley   +1 more source

Effect of ATP-sensitive Potassium Channel Openers on Intraocular Pressure in Ocular Hypertensive Animal Models. [PDF]

Invest Ophthalmol Vis Sci, 2022
Roy Chowdhury U, Millar JC, Holman BH, Anderson KJ, Dosa PI, Roddy GW, Fautsch MP.   +6 more
europepmc   +1 more source

Mitochondrial BK Channel Openers CGS7181 and CGS7184 Exhibit Cytotoxic Properties

, 2018
Potassium channel openers (KCOs) have been shown to play a role in cytoprotection through the activation of mitochondrial potassium channels. Recently, in several reports, a number of data has been described as off-target actions for KCOs. In the present
Adam Szewczyk, Bogusz Kulawiak, Piotr Koprowski, Wolfram Kunz, Bartłomiej Augustynek, Daria Rotko, Kulawiak, Bogusz, Koprowski, Piotr, Rotko, Daria, Augustynek, Bartłomiej, Szewczyk, Adam, Kunz, Wolfram   +11 more
core   +1 more source