Results 71 to 80 of about 5,395 (299)

Regulation of mitochondrial potassium BKCa channel by naringenin derivatives: application of a new cellular model

European Journal of Medicinal Chemistry Reports
Mitochondrial potassium (mitoK) channels play a crucial role in mitochondrial and cellular physiology. One of the best described mitoK channels is the mitochondrial large-conductance calcium-activated potassium (mitoBKCa) channel.
Aleksandra Sęk, Silvia Cammarone, Rafał P. Kampa, Karolina Pytlak, Barbara Kalenik, Joanna Lewandowska, Francesca Ghirga, Isabella Romeo, Omar Atrooz, Piotr Bednarczyk, Adam Szewczyk, Bruno Botta, Deborah Quaglio, Bogusz Kulawiak   +13 more
doaj   +1 more source

Preconditioning with associated blocking of Ca2+ inflow alleviates hypoxia-induced damage to pancreatic β-cells. [PDF]

PLoS ONE, 2013
Beta cells of pancreatic islets are susceptible to functional deficits and damage by hypoxia. Here we aimed to characterize such effects and to test for and pharmacological means to alleviate a negative impact of hypoxia.Rat and human pancreatic islets ...
Zuheng Ma, Noah Moruzzi, Sergiu-Bogdan Catrina, Ingrid Hals, José Oberholzer, Valdemar Grill, Anneli Björklund   +6 more
doaj   +1 more source

An ATP-sensitive K+ conductance in dissociated neurones from adult rat intracardiac ganglia [PDF]

, 2001
1. An ATP-sensitive K+ (K-ATP) conductance has been identified using the perforated patch recording configuration in a population (52%) of dissociated neurones from adult rat intracardiac ganglia.
Ron C. Hogg, David J. Adams, Gootman P. M., Hogg R. C.   +3 more
core   +1 more source

Modulating Two‐Photon Absorption in a Pyrene‐Based MOF Series: An In‐Depth Investigation of Structure–Property Relationships

Advanced Functional Materials, EarlyView.
This study investigates H4TBAPy‐based metal–organic frameworks (MOFs) ‐ NU‐1000, NU‐901, SrTBAPy, and BaTBAPy ‐ for multiphoton absorption (MPA) performance. It observes topology‐dependent variations in the 2PA cross‐section, with BaTBAPy exhibiting the highest activity.
Simon N. Deger, Helmy Pacheco Hernandez, Yang Cui, Hongxing Hao, Vanessa Ramm, David C. Mayer, Khai‐Nghi Truong, Roland A. Fischer, Jürgen Hauer, Mariana Kozlowska, Alexander Pöthig   +10 more
wiley   +1 more source

Фармакологическое прекондиционирование никорандилом как возможность повышения устойчивости тканей сетчатки к ишемии в эксперименте [PDF]

, 2015
У лабораторных крыс формировали ишемическое повреждение путем оказания механического давления (110 мм.рт.ст.) на переднюю камеру глаза в течение 30 минут.
Шабельникова, А. С.
core   +2 more sources

Biomass Native Structure Into Functional Carbon‐Based Catalysts for Fenton‐Like Reactions

Advanced Functional Materials, EarlyView.
This study indicates that eight biomasses with 2D flaky and 1D acicular structures influence surface O types, morphology, defects, N doping, sp2 C, and Co nanoparticles loading in three series of carbon, N‐doped carbon, and cobalt/graphitic carbon. This work identifies how these structural factors impact catalytic pathways, enhancing selective electron
Wenjie Tian, Jingkai Lin, Zhihao Tian, Selusiwe Ncube, Huayang Zhang, Emiliano Cortés, Hongqi Sun, Shaobin Wang   +7 more
wiley   +1 more source

The Cannabinoid-Like Compound, VSN16R, Acts on Large Conductance, Ca2+-Activated K+ Channels to Modulate Hippocampal CA1 Pyramidal Neuron Firing [PDF]

, 2019
Large conductance, Ca2+-activated K+ (BKCa) channels are widely expressed in the central nervous system, where they regulate action potential duration, firing frequency and consequential neurotransmitter release.
Benjamin J. Whalley, David Baker, David L. Selwood, Gary J. Stephens, Setareh Tabatabaee, Tao   +5 more
core   +3 more sources

DNA‐Templated 2D Heterostructures as Phototriggered Dynamic Nanohybrids: From Releasing Molecular Loads to Controlling Enzyme Biocatalytic Function

Advanced Functional Materials, EarlyView.
DNA strands are employed both as dynamic linkers and nanoscale templates for the integration of Ag2S nanoparticles on MoS2, which in turn imparted photothermal responsiveness; this feature permits the selective cargo (fluorophore, quantum dots or an enzyme) release from the MoS2 surface in response to local heat induced by light irradiation.
Kai Chen, Haosen Miao, Weiying Hong, Matteo Palma   +3 more
wiley   +1 more source

Novel drugs targeting genetic variants: current applications and future prospects in heart failure treatment

Frontiers in Molecular Biosciences
Chronic heart failure (HF) is a common and frequently occurring disease worldwide, and its traditional treatment methods are undergoing earth-shaking changes.
Xiang Li, Suwen Bai, Yumei Luo
doaj   +1 more source

Cantu syndrome–associated SUR2 (ABCC9) mutations in distinct structural domains result in KATP channel gain-of-function by differential mechanisms [PDF]

, 2018
The complex disorder Cantu syndrome (CS) arises from gainof-function mutations in either KCNJ8 or ABCC9, the genes encoding the Kir6.1 and SUR2 subunits of ATP-sensitive potassium (KATP) channels, respectively. Recent reports indicate that such mutations
Grange, Dorothy K., Hanson, Alex, Josifova, Dragana, McClenaghan, Conor, Nichols, Colin G., Roessler, Helen I., Sala-Rabanal, Monica, van Haaften, Gijs   +7 more
core   +2 more sources