Results 91 to 100 of about 3,196 (289)

Portable Molecularly Imprinted Polymer Sensor for Rapid Swab‐Based Detection of Norovirus

Advanced Healthcare Materials, EarlyView.
This work reports a rapid, portable smartphone‐based sensor capable of detecting four norovirus genotypes from swab samples within 15 min. Sensor selectivity was validated through evaluation against four common live viruses. The swab‐based sampling process enabled simple sample preparation combined with the compact detection system, supporting use of ...
Amy Dann, Pankaj Singla, Minji Kim, Sloane Stoufer, Clare Thomas, Robert D. Crapnell, Craig E. Banks, Jake McClements, Shayan Seyedin, Mark Geoghegan, Samuel T. Jones, Christopher F. Blanford, Matthew D. Moore, Marloes Peeters   +13 more
wiley   +1 more source

Potassium Channel Openers Exhibit Cross-tolerance with Morphine in Two Experimental Models of Pain [PDF]

, 2011
Objective: The study was performed to assess the effect of potassium channel openers on morphine tolerance and vice-versa. Methods: Swiss albino mice of either gender weighing between 25−30 g were used for the study.
. N Khanna, RS Malhotra, AK Mehta, GR Garg, S Halder, KK Sharma
core  

Encoded Cell‐Material Interactions to Reroute Cytokine Signaling for Regenerative Medicine

Advanced Healthcare Materials, EarlyView.
We present native MATRIX (Material Activated To Regulate Inducible gene eXpression), a co‐engineered material‐cell platform. Surfaces functionalized with antibodies for endogenous soluble ligands (e.g., IL‐1β or IL‐6) capture and immobilize ligands for presentation to a cognate, engineered synthetic Notch receptor, releasing a transcription factor (TF)
Zachary M. Eidman, Jhanvi Sharma, Joanne C. Lee, Nicholas F. Schulze, Hannah J. Brien, Kevin C. Corn, Marjan Rafat, Jonathan M. Brunger   +7 more
wiley   +1 more source

Benzenesulfonamides act as open-channel blockers on KV3.1 potassium channel

Amino Acids, 2018
KV3.1 blockers can serve as modulators of the rate of action potential firing in neurons with high rates of firing such as those of the auditory system. We studied the effects of several bioisosteres of N-alkylbenzenesulfonamides, and molecules derived from sulfanilic acid on KV3.1 channels, heterologously expressed in L-929 cells, using the whole-cell
Bassetto Junior, Carlos Alberto Zanutto, Passianoto, Luana Vitorino Gushiken, González, Eduardo René Pérez, Varanda, Wamberto Antonio   +3 more
openaire   +3 more sources

A Naphthalimide‐Based NIR‐Emissive AIE Photosensitizer for Synergistic Apoptosis/Ferroptosis‐Mediated Antitumor Therapy and Broad‐Spectrum Bacterial Inactivation With Rapid Wound Healing

Advanced Healthcare Materials, EarlyView.
An ionic naphthalimide AIE photosensitizer (PS), TPAPV‐NIM‐M, anchors to cellular and bacterial membranes, emits in the far‐red/near‐infrared (NIR) region, and efficiently generates reactive oxygen species (ROS) under white light. Its membrane‐localized photodynamic action drives apoptosis/ferroptosis‐mediated tumor suppression and broad‐spectrum ...
Sayed Mir Sayed, Zeeshan Tahir, Fahri Alkan, Yavuz Nuri Ertas   +3 more
wiley   +1 more source

Lack of effect of potassium channel openers on ATP-modulated potassium channels recorded from rat ventromedial hypothalamic neurones [PDF]

, 1992
1. Single neuronal cells were freshly isolated from the ventromedial hypothalamic nuclei (VMHN) of the rat brain. Currents through ATP-modulated and large conductance (160 and 250 pS) calcium-activated potassium channels were recorded by the cell ...
Ashford, M. L. J.; id_orcid, P.R. Boden, M.L.J. Ashford, A.J. Sellers, Sellers, A. J., Boden, P. R.   +5 more
core   +1 more source

Hypotonic Stress Increases Efficacy of Rilmakalim, but Not Pinacidil, to Activate ATP-Sensitive K+ Current in Guinea Pig Ventricular Myocytes

Journal of Pharmacological Sciences, 2004
The aim of this study was to investigate the influence of hypotonic challenge on the effects of potassium channel openers (PCO), rilmakalim and pinacidil, on activation of the ATP-sensitive K+ current.
Ivan Kocić, Yuji Hirano, Masayasu Hiraoka   +2 more
doaj   +1 more source

Ferroelectric Quantum Dots for Retinomorphic In‐Sensor Computing

Advanced Materials, EarlyView.
This work has provided a protocol for fabricating retinomorphic phototransistors by integrating ferroelectric ligands with quantum dots. The resulting device combines ferroelectricity, optical responsiveness, and low‐power operation to enable adaptive signal amplification and high recognition accuracy under low‐light conditions, while supporting ...
Tingyu Long, Huanyu Zhou, Jaewan Ko, Hongwei Tan, Jaemin Lim, Yanfei Zhao, Daehan Kang, Eojin Yoon, Gyeong‐Tak Go, Somin Kim, Seung‐Woo Lee, Chan‐Yul Park, Hyojun Choi, Hyeran Kim, Hyung Joong Yun, Sung Hyuk Park, Kwan Sik Park, Jeong Woo Park, Mungeun Kim, Yong Soo Cho, Ho Won Jang, Wenqiang Yang, Min Hyuk Park, Wan Ki Bae, Sebastiaan van Dijken, Joona Bang, Tae‐Woo Lee   +26 more
wiley   +1 more source

Chronic exposure to KATP channel openers results in attenuated glucose sensing in hypothalamic GT1-7 neurons [PDF]

, 2016
Individuals with Type 1 diabetes (T1D) are often exposed to recurrent episodes of hypoglycaemia. This reduces hormonal and behavioural responses that normally counteract low glucose in order to maintain glucose homeostasis, with altered responsiveness of
McCrimmon, Rory J.; id_orcid, Ashford, ML, Haythorne, Elizabeth, Hamilton, D. Lee, Haythorne, E, McCrimmon, Rory J., McCrimmon, Rory J, Hamilton, DL, Ashford, Michael L J, Hathorne , Elizabeth, Beall, Craig, Findlay, John A, Hamilton, David Lee, Findlay, John A., Findlay, JA, Ashford, Michael L. J.; id_orcid, Beall, C, McCrimmon, RJ, Ashford, Michael L.J.   +18 more
core   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source