Results 141 to 150 of about 19,368 (234)

Emerging Regulatory Mechanisms in Sinoatrial Node Automaticity

Journal of Cellular and Molecular Medicine, Volume 30, Issue 4, February 2026.
ABSTRACT The sinoatrial node (SAN), the primary cardiac pacemaker, governs rhythmic heartbeats through spontaneous electrical impulses. While the classical “coupled‐clock” theory, integrating the membrane voltage clock (driven by cyclic ion channel activity) and the calcium clock (orchestrated by rhythmic sarcoplasmic reticulum Ca2+ release), remains ...
Hongyu Liu, Yuting Cao, Xuling Su
wiley   +1 more source

Astrocyte Regulation of Spinal Circuit Function

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
Spinal cord astrocytes exist as an additional component of the computational framework that governs both sensory perceptions and motor outputs (left). By integrating local synaptic activity together with signals that reflect whole‐body state (e.g., neuromodulators, immune signals, and vascular signals) into defined input states (Sn), astrocytes adapt ...
Mary Kaye Duff, Min Jun Li, Axel Nimmerjahn   +2 more
wiley   +1 more source

Potentiation of Opioid-Induced Analgesia by L-Type Calcium Channel Blockers: Need for Clinical Trial in Cancer Pain

Indian Journal of Anaesthesia, 2008
Previous reports indicate that the analgesic effect of opioids is due to both closure of specific voltage-gated calcium channels (N- and P/Q-types) and opening of G protein-coupled inwardly rectifying potassium channels (GIRKs) in neurons concerned with ...
S Basu Ray, Raj D Mehra
doaj  

Emerging methods for subtype differentiation in primary aldosteronism

Journal of Internal Medicine, Volume 299, Issue 2, Page 178-195, February 2026.
Abstract Primary aldosteronism (PA) is a common cause of hypertension. Compared to patients with essential hypertension, untreated PA is associated with a two‐ to fourfold greater risk of cardiovascular disease, renal failure, and death. PA is caused by increased secretion of aldosterone from one adrenal gland in 30% of the patients and both adrenal ...
Oskar Ragnarsson, C. Christofer Juhlin, Tobias Åkerström, Per Dahlqvist, Henrik Falhammar, Per Hellman   +5 more
wiley   +1 more source

Ligand transduction mechanisms of inwardly-rectifying potassium channels

, 2013
Regulation of inwardly-rectifying potassium (Kir) channels by intracellular ligands couples cell membrane excitability to important signaling cascades and metabolic pathways. Particularly, the ATP-sensitive potassium (KATP) channels, highly expressed in diverse excitable tissues, are the keystone components of glucose-stimulated insulin secretion in ...
openaire   +1 more source

Control of Kir channel gating by cytoplasmic domain interface interactions [PDF]

, 2017
Alekseev, Alekseev, Amorós, Antcliff, Bichet, Bushman, Bushman, Clarke, Colin G. Nichols, Drain, Dürr, Enkvetchakul, Enkvetchakul, Enkvetchakul, Eswar, Gloyn, Gribble, Hansen, Hibino, Hilgemann, Huang, Inagaki, Inagaki, Jiang, Koster, Koster, Kumar, Kuo, Kurata, Lederer, Lee, Lee, Lin, Lin, Lin, Linder, Loechner, Lopatin, Lopes, Loussouarn, Loussouarn, Lu, Martin, Nichols, Nichols, Nichols, Nichols, Proks, Proks, Qin, Qin, Qin, Qin, Remedi, Ribalet, Ribalet, Schwalbe, Shimomura, Shizhen Wang, Shyng, Shyng, Shyng, Shyng, Shyng, Shyng, Sievers, Sobolevsky, Sobolevsky, Suh, Sunjoo Lee, Tao, Trapp, Trapp, Whorton, William F. Borschel, Zhang, Zhu, Zubcevic   +77 more
core   +2 more sources

Two-Pore Domain Potassium Channels [PDF]

, 2015
Goldstein, Steve, Plant, Leigh
core   +1 more source

Further Structure-Activity Relationship of G Protein-Gated Inwardly Rectifying Potassium Channels 1/2 Activators: Synthesis and Biological Characterization of In Vitro Tool Compounds. [PDF]

ChemMedChem
Nahid S, Rahman FI, Du Y, Spitznagel BD, Singh SK, Chhonker YS, Murry DJ, Weaver CD, Hopkins CR.   +8 more
europepmc   +1 more source

Inwardly rectifying potassium channels promote directional sensing during neutrophil chemotaxis. [PDF]

J Cell Biol
Wang T, Kim DH, Ding C, Wang D, Zhang W, Silic M, Cheng X, Shao K, Ku T, Zheng C, Xie J, Xiao S, Jayant K, Yuan C, Chubykin AA, Staiger CJ, Zhang G, Deng Q.   +17 more
europepmc   +1 more source

When the U Wave Tells the Story: Andersen-Tawil Syndrome Unmasked. [PDF]

Ann Noninvasive Electrocardiol
Yu S, Lv H.
europepmc   +1 more source