Results 51 to 60 of about 1,012,810 (287)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Commercial Video Games As Therapy: A New Research Agenda to Unlock the Potential of a Global Pastime
Frontiers in Psychiatry, 2018 Emerging research suggests that commercial, off-the-shelf video games have potential applications in preventive and therapeutic medicine. Despite these promising findings, systematic efforts to characterize and better understand this potential have not ...
Michelle Colder Carras +9 more
doaj +1 more source
Winning Over the Players: Investigating the Motivations to Play and Acceptance of Serious Games
Media and Communication, 2021 Serious games are designed to educate, train, or persuade their players on specific topics and issues. While a lot of studies have sought to prove the effects of these games, the overall image and legitimization of serious games has not benefited fully ...
Ruud S. Jacobs
doaj +1 more source
Decompositions of two player games: potential, zero-sum, and stable games [PDF]
, 2011 We introduce several methods of decomposition for two player normal form games. Viewing the set of all games as a vector space, we exhibit explicit orthonormal bases for the subspaces of potential games, zero-sum games, and their orthogonal complements ...
Hwang, Sung-Ha, Rey-Bellet, Luc
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Use of Branch and Bound Method for Search of an Equilibrium in Potential Cournot Model
Известия Иркутского государственного университета: Серия "Математика", 2014 It is known that Nash equilibria of potential game belong to the set of stationary points of the potential, moreover only the potential’s global maximum is an equilibrium in general case.
I.M. Minarchenko
doaj
Games, 2011 A new model of strategic networking is developed and analyzed, where an agent’s investment in links is nonspecific. The model comprises a large class of games which are both potential and super- or submodular games.
Philippe Solal +2 more
doaj +1 more source
A Characterization of Ordinal Potential Games [PDF]
Games and Economic Behavior, 1997 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Voorneveld, M., Norde, H.W.
openaire +4 more sources
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Mean-Potential Law in Evolutionary Games [PDF]
Physical Review Letters, 2018 The Letter presents a novel way to connect random walks, stochastic differential equations, and evolutionary game theory. We introduce a new concept of potential function for discrete-space stochastic systems. It is based on a correspondence between one-dimensional stochastic differential equations and random walks, which may be exact not only in the ...
Nałęcz-Jawecki, Paweł +1 more
openaire +3 more sources