Results 111 to 120 of about 52,072 (220)

Microcystin‐LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity

Advanced Science, Volume 13, Issue 9, 13 February 2026.
MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang, Qi Gao, Yi Peng, Huan Zhang, Qi Shen, Meihong Guo, Yuqing Gong, Lei Chu, Weidong Wu, Yanting Wen, Wangsen Cao, Yong Wang, Lihui Wang   +12 more
wiley   +1 more source

State‐of‐the‐Art Strategies for Circular RNA in Cancers: Opportunity and Challenge

MedComm, Volume 7, Issue 2, February 2026.
Overview of circular RNA in tumors. ABSTRACT Circular RNAs (circRNAs) are characterized by their covalently closed structure, remarkable stability, and precise spatiotemporal regulation, evolving from once‐overlooked transcriptional byproducts to pivotal molecular regulators.
Zehao Ding, Zai Luo, Liao Zhang, Shaopeng Zhang, Renchao Zhang, Zhengjun Qiu, Chen Huang   +6 more
wiley   +1 more source

Phosphorylation of Spinophilin Modulates Its Interaction with Actin Filaments [PDF]

, 2003
Spinophilin is a protein phosphatase 1 (PP1)- and actin-binding protein that modulates excitatory synaptic transmission and dendritic spine morphology. We report that spinophilin is phosphorylated in vitro by protein kinase A (PKA).
Allen, Patrick B., Benfenati, Fabio, Greengard, Paul, Hsieh-Wilson, Linda C., Nairn, Angus C., Snyder, Gretchen L.   +5 more
core  

C3G mediated suppression of malignant transformation involves activation of PP2A phosphatases at the subcortical actin cytoskeleton [PDF]

, 2012
In previous work, we demonstrated that C3G suppresses Ras oncogenic transformation by a mechanism involving inhibition of ERK phosphorylation. Here we present evidences indicating that this suppression mechanism is mediated, at least in part, by serine ...
Ayoub, N., Ghassemi, A., Ghassemi, M., Goloborodko, E., Holzle, F., Lethaus, B., Loberg, C., Modabber , A., Mohlhenrich, S.C., Sonmez, T.T.   +9 more
core   +2 more sources

Targeting dCas9‐SunTag to a Susceptibility Gene Promoter Is Sufficient for CRISPR Interference

Plant Direct, Volume 10, Issue 2, February 2026.
ABSTRACT Cassava production in sub‐Saharan Africa is severely impacted by diseases. Most pathogens require interaction with host susceptibility factors to complete their life cycles and cause disease. Targeted DNA methylation is an epigenetic strategy to alter gene expression in plants, and we previously reported that a zinc‐finger fused to DMS3 could ...
Zuh‐Jyh Daniel Lin, Gabriela L. Hernandez, Myia K. Stanton, Xingguo Zheng, Kerrigan B. Gilbert, Kira M. Veley, Greg Jensen, Marisa Yoder, Suhua Feng, Basudev Ghoshal, Jason Gardiner, Ming Wang, Steven E. Jacobsen, James C. Carrington, Rebecca S. Bart   +14 more
wiley   +1 more source

Midline1 and the development of the cranial peripheral nervous system [PDF]

, 2008
Genetic abnormalities involving the skull and facial region account for around 1/3 of birth defects. Opitz BBB/G syndrome is one such disorder that gives rise to craniofacial malformations, as well as midline defects that cause gastrointestinal ...
Golding, Jon, Latta, Elizabeth, Saffrey, Jill   +2 more
core  

Cerebral endothelial 3-mercaptopyruvate sulfurtransferase improves ischemia-induced cognitive impairment via interacting with protein phosphatase 2A

Acta Pharmaceutica Sinica B
The catalytic activity of 3-mercaptopyruvate (3MP) sulfurtransferase (MPST) converts 3MP to hydrogen sulfide (H2S). However, the regulatory mechanisms governing MPST and its impact on the brain remain largely unexplored.
Li Zhu, Yi Huang, Jing Jin, Rongjun Zou, Rui Zuo, Yong Luo, Ziqing Song, Linfeng Dai, Minyi Zhang, Qiuhe Chen, Yunting Wang, Wei Wang, Rongrong He, Yang Chen   +13 more
doaj   +1 more source

T Cell Exhaustion in Hepatocellular Carcinoma: A Substantial Barrier in Immunotherapy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Hepatocellular carcinoma (HCC), accounting for over 90% of primary liver cancers, remains a major global challenge for healthcare professionals. While immunotherapy has transformed the landscape of cancer treatment, its success is often limited by immune resistance, particularly through T cell exhaustion which remains a major barrier to ...
Kosar Nouri, Negar Asadollahei, Yasamin Haghir‐Sharif‐Zamini, Homeyra Seydi, Mahsa Salehi, Mehrnaz Mesdaghi, Mustapha Najimi, Massoud Vosough   +7 more
wiley   +1 more source

Integration of light quality signals regulates ABA abundance and stomatal movements during seedling establishment

New Phytologist, Volume 249, Issue 3, Page 1253-1267, February 2026.
Summary Obtaining sufficient light for photosynthesis and avoiding desiccation are two key challenges faced by seedlings during early establishment. Perception of light quality via specialised photoreceptors signals the availability of sunlight for photosynthesis.
Mathilda Gustavsson, Lionel Hill, Keara A. Franklin, Ashley J. Pridgeon   +3 more
wiley   +1 more source

Novel PP2A-Activating Compounds in Neuroblastoma

Cancers
Background: Neuroblastoma (NB) remains one of the deadliest pediatric solid tumors. Recent advancements aimed at improving outcomes have been insufficient, and patients with high-risk NB continue to have a poor prognosis. Protein phosphatase 2A (PP2A) is a tumor suppressor protein downregulated in many cancers, including NB.
Nazia Nazam, Laura V. Bownes, Janet R. Julson, Colin H. Quinn, Michael H. Erwin, Raoud Marayati, Hooper R. Markert, Sorina Shirley, Jerry E. Stewart, Karina J. Yoon, Jamie Aye, Michael Ohlmeyer, Elizabeth A. Beierle   +12 more
openaire   +2 more sources