Animal Cells and Systems, 2018 Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7) are inositol metabolites with high-energy phosphoanhydride bonds. The formation of PP-IPs is catalyzed by two groups of enzymes, the IP6 kinases and the PPIP5 kinases,
Seung Ju Park +3 more
doaj +1 more source
Inositol phosphate kinases in the eukaryote landscape [PDF]
, 2020 Inositol phosphate encompasses a large multifaceted family of signalling molecules that originate from the combinatorial attachment of phosphate groups to the inositol ring. To date, four distinct inositol kinases have been identified, namely, IPK, ITPK,
Desfougères, Y +3 more
core
Stable Isotopomers of myo-Inositol Uncover a Complex MINPP1-Dependent Inositol Phosphate Network [PDF]
, 2022 The water-soluble inositol phosphates (InsPs) represent a functionally diverse group of small-molecule messengers involved in a myriad of cellular processes.
Fandi, Zeinab +9 more
core +2 more sources
Inositol phosphate pathway evolution and synthesis in Dictyostelium discoideum [PDF]
, 2020 Inositol phosphates (InsPs) are polar water-soluble derivatives of the six- carbon cyclitol inositol. They are synthesized, through phosphorylation reactions, by kinases of four distinct families: IPK, IP5-2K, ITPK1 and PPIP5K, which are thought to be ...
Portela Torres, Paloma
core
Genome editing and cancer: How far has research moved forward on CRISPR/Cas9? [PDF]
, 2022 Financiado para publicación en acceso aberto: Universidade de Vigo/CISUGCancer accounted for almost ten million deaths worldwide in 2020. Metastasis, characterized by cancer cell invasion to other parts of the body, is the main cause of cancer morbidity ...
Alshahrani, Asma M. +10 more
core +1 more source
One scaffold, two conformations: the ring-flip of the messenger InsP8 occurs under cytosolic conditions [PDF]
, 2023 Inositol poly- and pyrophosphates (InsPs and PP-InsPs) are central eukaryotic messengers. These very highly phosphorylated molecules can exist in two distinct conformations, a canonical one with five phosphoryl groups in equatorial positions, and a ...
core +1 more source
Importance of Radioactive Labelling to Elucidate Inositol Polyphosphate Signalling [PDF]
, 2017 Inositol polyphosphates, in their water-soluble or lipid-bound forms, represent a large and multifaceted family of signalling molecules. Some inositol polyphosphates are well recognised as defining important signal transduction pathways, as in the case ...
Saiardi, A, Wilson, MSC
core
Analysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry [PDF]
, 2020 The analysis of myo-inositol phosphates (InsPs) and myo-inositol pyrophosphates (PP-InsPs) is a daunting challenge due to the large number of possible isomers, the absence of a chromophore, the high charge density, the low abundance, and the instability ...
Eisenbeis, VB +14 more
core
Application of CRISPR-Cas9 gene editing technology in basic research, diagnosis and treatment of colon cancer [PDF]
, 2023 Colon cancer is the fourth leading cause of cancer death worldwide, and its progression is accompanied by a complex array of genetic variations. CRISPR/Cas9 can identify new drug-resistant or sensitive mutations in colon cancer, and can use gene editing ...
Hui Meng +5 more
core +1 more source
First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase [PDF]
, 2012 We synthesised analogues of diphosphoinositol polyphosphates (PP-InsPs) in which the diphosphate is replaced by an α-phosphonoacetic acid (PA) ester. Structural analysis revealed that 5-PA-InsP5 mimics 5-PP-InsP 5 binding to the kinase domain of PPIP5K2;
Potter, BVL +4 more
core +2 more sources