Results 91 to 100 of about 16,876 (211)
Comprehensive Physiology, Volume 16, Issue 2, April 2026.Pancreatic exocrine microcirculation exhibits sexual dimorphism arising from steroid–genetic interactions. Laser Doppler flowmetry combined with wavelet analysis identifies a male passive coupling phenotype aligned with systemic pressure and a female active vasomotion phenotype driven by ERβ‐mediated, NO‐dependent oscillations.
Yuan Li +8 more
wiley +1 more source
Origin and diversification of steroids: Co-evolution of enzymes and nuclear receptors [PDF]
, 2010 Recent sequencing of amphioxus and sea urchin genomes has provided important data for understanding the origins of enzymes that synthesize adrenal and sex steroids and the receptors that mediate physiological response to these vertebrate steroids ...
Michael E. Baker
core +1 more source
Pregnane X receptor polymorphisms associated with human diseases
Expert Opinion on Therapeutic Targets, 2013 Pregnane X receptor (PXR) belongs to the nuclear hormone receptor superfamily and is mostly expressed in liver and intestine. PXR is activated by a wide range of compounds, including drugs, and regulates the transcription of numerous metabolic enzymes implicated in cellular response to xenobiotics. Genetic variation in the PXR gene may influence a wide
Kotta-Loizou, I. +2 more
openaire +3 more sources
The Structural Basis of Pregnane X Receptor Binding Promiscuity [PDF]
Biochemistry, 2009 The steroid and xenobiotic-responsive human pregnane X receptor (PXR) binds a broad range of structurally diverse compounds. The structures of the apo and ligand-bound forms of PXR are very similar, in contrast to most promiscuous proteins that generally adapt their shape to different ligands. We investigated the structural origins of PXR's recognition
Chi-Ho, Ngan +5 more
openaire +2 more sources
MedComm, Volume 7, Issue 4, April 2026.Microbiome‐based clustering investigated possible glycemic control‐related endotypes in youth with recent‐onset T1D, and found a potential role of Bacteroides and skatole production in glycemic control. This study offers novel perspectives on the influence of intestinal microbes and its metabolites in T1D heterogeneity and lays a foundation for future ...
Huiling Tan +13 more
wiley +1 more source
Cell & Bioscience, 2021 Background Intestinal dysbiosis is believed to be one of the factors inducing neonatal necrotizing enterocolitis (NEC). Probiotics have been employed to treat NEC in a number of animal experiments and clinical trials, and some significant benefits of ...
Xiuhao Zhao +8 more
doaj +1 more source
Expression, localization and polymorphisms of the nuclear receptor PXR in Barrett's esophagus and esophageal adenocarcinoma [PDF]
, 2011 Background: The continuous exposure of esophageal epithelium to refluxate may induce ectopic expression of bile-responsive genes and contribute to the development of Barrett's esophagus (BE) and esophageal adenocarcinoma. In normal physiology of the
Anouk van de Winkel +9 more
core +5 more sources
The Nuclear Pregnane X Receptor Regulates Xenobiotic Detoxification [PDF]
The Journal of Nutrition, 2003 The pregnane X receptor (PXR), which is a member of the nuclear receptor family of ligand-activated transcription factors, is an integral component of the body's defense mechanism against toxic xenobiotics. PXR is activated by a broad spectrum of lipophilic xenobiotics including prescription drugs, herbs, pesticides, endocrine disruptors and other ...
openaire +2 more sources
Pregnane X receptor promotes ethanol-induced hepatosteatosis in mice [PDF]
Journal of Biological Chemistry, 2018 The pregnane X receptor (PXR, NR1I2) is a xenobiotic-sensing nuclear receptor that modulates the metabolic response to drugs and toxic agents. Both PXR activation and deficiency promote hepatic triglyceride accumulation, a hallmark feature of alcoholic liver disease.
Sora, Choi +4 more
openaire +2 more sources
Molecular Ecology Resources, Volume 26, Issue 3, April 2026.ABSTRACT The coevolutionary radiation of 27 species of Tetraopes longhorned beetles and their Asclepias milkweed hosts represents a classic example of adaptive evolution driven by plant chemical defences and herbivore counteradaptations. Investigations to date, however, have focused on a single species, Tetraopes tetrophthalmus, which feeds on the ...
Sangil Kim, Brian D. Farrell
wiley +1 more source