Results 101 to 110 of about 16,921 (212)

Insight into the molecular recognition of human and polar bear pregnane X receptor by three organic pollutants using molecular docking and molecular dynamics simulations

Environment International
Pregnane X receptor (PXR) is a heterologous biosensor that is involved in the metabolic pathway of environmental pollutants, regulating the transcription of genes involved in biotransformation.
Ruige Wang, Yaqi Lin, Ying Sun, Bing Zhao, Lin Chen   +4 more
doaj   +1 more source

Constitutive androstane receptor and pregnane X receptor genotype influence efavirenz plasma concentration and CYP2B6 enzyme activity

Scientific Reports, 2022
Efavirenz is metabolized by CYP2B6, an inducible enzyme whose expression is regulated by the constitutive androstane receptor and pregnane X receptor nuclear receptors. CAR and PXR are encoded by genetically polymorphic NR1I2 and NR1I3, respectively.
Zelalem Petros, Abiy Habtewold, Eyasu Makonnen, Eleni Aklillu   +3 more
doaj   +1 more source

Phallusiasterol C, A New Disulfated Steroid from the Mediterranean Tunicate Phallusia fumigata [PDF]

, 2016
A new sulfated sterol, phallusiasterol C (1), has been isolated from the Mediterranean ascidian Phallusia fumigata and its structure has been determined on the basis of extensive spectroscopic (mainly 2D NMR) analysis. The possible role in regulating the
Aiello, A, Carino, A, CARINO, ADRIANA, D'Amore, C, FIORUCCI, Stefano, Imperatore, C, Luciano, P, Menna, M., Senese, M   +8 more
core   +2 more sources

Model‐based evaluation of the interaction between ritonavir‐boosted atazanavir and rifampicin in Ugandan adults with HIV

British Journal of Clinical Pharmacology, Volume 91, Issue 12, Page 3471-3481, December 2025.
Aim Concomitant treatment of tuberculosis (TB) and human immunodeficiency virus (HIV) is complicated by drug‐drug interactions (DDI). This analysis aimed to characterize the DDI between ritonavir‐boosted atazanavir (ATV/r) and rifampicin in plasma and peripheral blood mononuclear cells (PBMC).
Allan Kengo, Juan Eduardo Resendiz‐Galvan, Letisha Najjemba, Henry Mugerwa, Amedeo De Nicolò, Antonio D'Avolio, Shakir Atoyebi, Lubbe Wiesner, Elin M. Svensson, Catriona Waitt, Paolo Denti   +10 more
wiley   +1 more source

Marine and Semi-Synthetic Hydroxysteroids as New Scaffolds for Pregnane X Receptor Modulation

Marine Drugs, 2014
In recent years many sterols with unusual structures and promising biological profiles have been identified from marine sources. Here we report the isolation of a series of 24-alkylated-hydroxysteroids from the soft coral Sinularia kavarattiensis, acting
Valentina Sepe, Francesco Saverio Di Leva, Claudio D'Amore, Carmen Festa, Simona De Marino, Barbara Renga, Maria Valeria D'Auria, Ettore Novellino, Vittorio Limongelli, Lisette D'Souza, Mahesh Majik, Angela Zampella, Stefano Fiorucci   +12 more
doaj   +1 more source

A Targeted in Vivo SILAC Approach for Quantification of Drug Metabolism Enzymes:Regulation by the Constitutive Androstane Receptor [PDF]

, 2013
The modulation of drug metabolism enzyme (DME) expression by therapeutic agents is a central mechanism of drug-drug interaction and should be assessed as early as possible in preclinical drug development.
Henderson, Colin J., Huang, Jeffrey T.-J., Macleod, A. Kenneth, Riches, Zoe, Wolf, C. Roland, Zang, Tuo   +5 more
core   +5 more sources

Challenges in optimizing tacrolimus therapy in patients treated with rifampin: A case series

British Journal of Clinical Pharmacology, Volume 91, Issue 12, Page 3542-3548, December 2025.
Tacrolimus is a cornerstone immunosuppressant in transplantation medicine with a narrow therapeutic window. Drug–drug interactions with strong CYP3A4 and P‐glycoprotein modulators, such as rifampin and azole antifungals, significantly alter tacrolimus exposure and complicate therapy. Two transplant cases illustrates the impact of rifampin on tacrolimus
Jeroen P. A. Houwen, Aurelia H. M. de Vries Schultink, Bas J. M. Peters, Dieuwertje Ruigrok, Rob H. J. Schönwetter, Esther V. Uijtendaal, Maaike A. Sikma   +6 more
wiley   +1 more source

Origin and diversification of steroids: Co-evolution of enzymes and nuclear receptors [PDF]

, 2010
Recent sequencing of amphioxus and sea urchin genomes has provided important data for understanding the origins of enzymes that synthesize adrenal and sex steroids and the receptors that mediate physiological response to these vertebrate steroids ...
Michael E. Baker
core   +1 more source

The Concise Guide to PHARMACOLOGY 2015/16:Nuclear hormone receptors [PDF]

, 2015
The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org),
Aldrich, R, Alexander, SPH, Attali, B, Back, M, Barnes, NM, Bathgate, R, Beart, PM, Becirovic, E, Benson, HE, Biel, M, Birdsall, NJ, Boison, D, Brauner-Osborne, H, Broeer, S, Bryant, C, Burnstock, G, Burris, T, Cain, D, Calo, G, Chan, SL, Chandy, KG, Chiang, N, Christakos, S, Christopoulos, A, Chun, JJ, Chung, J-J, Cidlowski, JA, Clapham, DE, Connor, MA, Coons, L, Cox, HM, Dautzenberg, FM, Davies, JA, Dent, G, Douglas, SD, Dubocovich, ML, Edwards, DP, Faccenda, E, Farndale, R, Fong, TM, Forrest, D, Fowler, CJ, Fuller, P, Gainetdinov, RR, Gershengorn, MA, Goldin, A, Goldstein, SAN, Grimm, SL, Grissmer, S, Gundlach, AL, Hagenbuch, B, Hammond, JR, Hancox, JC, Hartig, S, Hauger, RL, Hay, DL, Hebert, T, Hollenberg, AN, Holliday, ND, Hoyer, D, Ijzerman, AP, Inui, KI, Ishii, S, Jacobson, KA, Jan, LY, Jarvis, GE, Jensen, R, Jetten, A, Jockers, R, Kaczmarek, LK, Kanai, Y, Kang, HS, Karnik, S, Kelly, E, Kerr, ID, Korach, KS, Lange, CA, Larhammar, D, Leeb-Lundberg, F, Leurs, R, Lolait, SJ, Macewan, D, Maguire, JJ, Marrion, N, May, JM, Mazella, J, McArdle, CA, McDonnell, DP, Michel, MC, Miller, LJ, Mitolo, V, Monie, T, Monk, PN, Mouillac, B, Murphy, PM, Nahon, J-L, Nerbonne, J, Nichols, CG, Norel, X, Oakley, R, Offermanns, S, Palmer, LG, Panaro, MA, Pawson, AJ, Perez-Reyes, E, Pertwee, RG, Peters, JA, Pike, JW, Pin, JP, Pintor, S, Plant, LD, Poyner, DR, Prossnitz, ER, Pyne, S, Ren, D, Richer, JK, Rondard, P, Ross, RA, Sackin, H, Safi, R, Sanguinetti, MC, Sartorius, CA, Segaloff, DL, Sharman, JL, Sladek, FM, Southan, C, Stewart, G, Stoddart, LA, Striessnig, J, Summers, RJ, Takeda, Y, Tetel, M, Toll, L, Trimmer, JS, Tsai, M-J, Tsai, SY, Tucker, S, Usdin, TB, Vilargada, J-P, Vore, M, Ward, DT, Waxman, SG, Webb, P, Wei, AD, Weigel, N, Willars, GB, Winrow, C, Wong, SS, Wulff, H, Ye, RD, Young, M, Zajac, J-M   +151 more
core   +4 more sources

The Blood–Brain Barrier as an Integration Hub in Alzheimer's Disease: How Microbiota Metabolites Modulate Central Signal Processing

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
The review reframes the blood–brain barrier as an active integrator of microbiota‐derived signals that shape vulnerability to Alzheimer's disease. Viewing the BBB as a dynamic processing interface between gut and brain clarifies why identical metabolite patterns yield different outcomes and opens new opportunities for earlier diagnosis and targeted ...
O. Giangiulio, R. Maccarone
wiley   +1 more source