Results 101 to 110 of about 16,876 (211)

Intestinal Pregnane X Receptor Links Xenobiotic Exposure and Hypercholesterolemia [PDF]

Molecular Endocrinology, 2015
AbstractRecent studies have associated endocrine-disrupting chemical (EDC) exposure with the increased risk of cardiovascular disease in humans, but the underlying mechanisms responsible for these associations remain elusive. Many EDCs have been implicated in activation of the nuclear receptor pregnane X receptor (PXR), which acts as a xenobiotic ...
Yipeng, Sui, Robert N, Helsley, Se-Hyung, Park, Xiulong, Song, Zun, Liu, Changcheng, Zhou   +5 more
openaire   +2 more sources

Insight into the molecular recognition of human and polar bear pregnane X receptor by three organic pollutants using molecular docking and molecular dynamics simulations

Environment International
Pregnane X receptor (PXR) is a heterologous biosensor that is involved in the metabolic pathway of environmental pollutants, regulating the transcription of genes involved in biotransformation.
Ruige Wang, Yaqi Lin, Ying Sun, Bing Zhao, Lin Chen   +4 more
doaj   +1 more source

Constitutive androstane receptor and pregnane X receptor genotype influence efavirenz plasma concentration and CYP2B6 enzyme activity

Scientific Reports, 2022
Efavirenz is metabolized by CYP2B6, an inducible enzyme whose expression is regulated by the constitutive androstane receptor and pregnane X receptor nuclear receptors. CAR and PXR are encoded by genetically polymorphic NR1I2 and NR1I3, respectively.
Zelalem Petros, Abiy Habtewold, Eyasu Makonnen, Eleni Aklillu   +3 more
doaj   +1 more source

Identification of neuroactive steroids and their precursors and metabolites in adult male rat brain [PDF]

, 2005
Steroids in the brain arise both from local synthesis and from peripheral sources and have a variety of effects on neuronal function. However, there is little direct chemical evidence for the range of steroids present in brain or of the pathways for ...
Corol, DI, Ebner, MJ, Fry, JP, Havlikova, H, Honour, JW   +4 more
core   +1 more source

Prioritising research on endocrine disruption in the marine environment: a global perspective

Biological Reviews, Volume 101, Issue 2, Page 848-868, April 2026.
ABSTRACT A healthy ocean is a crucial life support system that regulates the global climate, is a source of oxygen and supports major economic activities. A vast and understudied biodiversity from micro‐ to macro‐organisms is integral to ocean health.
Patricia I. S. Pinto, Angelica Miglioli, Carlie A. LaLone, Lisa Baumann, Alice Baynes, Mélanie Blanc‐Legendre, Ibon Cancio, Xavier Cousin, ZhiChao Dang, Rémi Dumollard, Alex T. Ford, Christopher Green, Taisen Iguchi, Philippa Kearney, Thomas Knigge, Christophe Minier, Tiphaine Monsinjon, Marta S. Monteiro, Joachim Sturve, Haruna Watanabe, Hiroshi Yamamoto, Gerald Ankley, Deborah M. Power, Ioanna Katsiadaki   +23 more
wiley   +1 more source

Marine and Semi-Synthetic Hydroxysteroids as New Scaffolds for Pregnane X Receptor Modulation

Marine Drugs, 2014
In recent years many sterols with unusual structures and promising biological profiles have been identified from marine sources. Here we report the isolation of a series of 24-alkylated-hydroxysteroids from the soft coral Sinularia kavarattiensis, acting
Valentina Sepe, Francesco Saverio Di Leva, Claudio D'Amore, Carmen Festa, Simona De Marino, Barbara Renga, Maria Valeria D'Auria, Ettore Novellino, Vittorio Limongelli, Lisette D'Souza, Mahesh Majik, Angela Zampella, Stefano Fiorucci   +12 more
doaj   +1 more source

Temporal and spatial expression patterns of pregnane X receptor and vitamin K epoxide reductase genes, two core molecular players on fish vitamin K homeostasis and skeletal development. [PDF]

, 2012
Vitamin K (VK) is a liposoluble vitamin known to be essential for bone metabolism by two different pathways: (i) by its role as a coenzyme in the gamma-carboxylation of some skeletal proteins (e.g.
Cancela, Leonor, Fernández, Ignacio, Gavaia, Paulo J.   +2 more
core  

Dysbiosis in the Gut‐Liver Axis Is Associated With Low Bone Mass During Murine Cholestasis

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Dysbiosis in the gut‐liver axis drives a dysregulation in bile acid metabolism that increases bile acid efflux into systemic circulation and the bone marrow. Bile acid signaling in the marrow promotes osteoclastogenesis and suppresses osteoblastogenesis, which drives bone loss during cholestatic liver disease in mice. ABSTRACT The gut‐liver axis is the
Brooke Hutchison, Jamie Fornsaglio, Ridgeway Case IV, Pam Cornuet, Fu‐Ying Qin, Xiaochao Ma, Kari Nejak‐Bowen, Matthew D. Carson   +7 more
wiley   +1 more source

Western Diet Inhibits FUT7‐Mediated Treg Intestinal Homing to Disrupt the Homeostasis of Intestinal Epithelial Cells in Crohn's Disease

Advanced Science, Volume 13, Issue 13, 3 March 2026.
In this study, we constructed a nanoparticle that was CD4 antibody‐mediated targeted, Fut7‐expressing plasmid‐loaded cationic liposome, namely CD4‐LDP‐Fut7. Upregulation of Fut7 expression in Tregs by using CD4‐LDP‐Fut7 can increase Treg homing to the intestine, thereby facilitating repair of the intestinal epithelial barrier and inhibiting ...
Qian Zhou, Xianfei Wang, Teng Ben, Chunping Zhu, Xinlong Lin, Yinmu Li, Xinyue Zhang, Yeling Chen, Yuchen Xuan, Huaiwen Chen, Ke Liu, Fang Wu, Yuexin Ren, Gao Tan   +13 more
wiley   +1 more source

Biology of PXR [PDF]

, 2014
Hormonal homeostasis is essential for a variety of physiological and pathological processes. Elimination and detoxification of xenobiotics, such as drugs introduced into the human body, could disrupt the balance of hormones due to the induction of drug ...
Dai, Shu, Guo, Yan, Wang, Jing, Xie, Wen, Zhai, Yonggong   +4 more
core