Results 101 to 110 of about 235,181 (316)
Resveratrol as an Inhibitor of Pregnane X Receptor (PXR): Another Lesson in PXR Antagonism
Journal of Pharmacological Sciences, 2014 .: The pregnane X receptor (PXR) plays a central role in the regulation of metabolism. Only few PXR antagonists have been described and the mechanism of PXR inhibition is mostly hypothetical or believed to be allosteric.
Tomas Smutny, Petr Pavek
doaj
Pregnane X receptor knockout mice display aging-dependent wearing of articular cartilage.
PLoS ONE, 2015 Steroid and xenobiotic receptor (SXR) and its murine ortholog, pregnane X receptor (PXR), are nuclear receptors that are expressed at high levels in the liver and the intestine where they function as xenobiotic sensors that induce expression of genes ...
Kotaro Azuma +6 more
doaj +1 more source
Marine and Semi-Synthetic Hydroxysteroids as New Scaffolds for Pregnane X Receptor Modulation
Marine Drugs, 2014 In recent years many sterols with unusual structures and promising biological profiles have been identified from marine sources. Here we report the isolation of a series of 24-alkylated-hydroxysteroids from the soft coral Sinularia kavarattiensis, acting
Valentina Sepe +12 more
doaj +1 more source
A Thermodynamic Model for Receptor Clustering [PDF]
, 1999 Intracellular signaling often arises from ligand-induced oligomerization of cell surface receptors. This oligomerization or clustering process is fundamentally a cooperative behavior between near-neighbor receptor molecules; the properties of this cooperative process clearly affects the signal transduction.
arxiv +1 more source
High- and low-conductance NMDA receptors are present in layer 4 spiny stellate and layer 2/3 pyramidal neurons of mouse barrel cortex [PDF]
Physiological Reports, 30th Dec. 2016, Vol. 4 no. e13051, 2016 NMDA receptors are ion channels activated by the neurotransmitter glutamate in the mammalian brain and are important in synaptic function and plasticity, but are also found in extrasynaptic locations and influence neuronal excitability. There are different NMDA receptor subtypes which differ in their single-channel conductance.
arxiv +1 more source
Journal of Pharmacology and Experimental Therapeutics, 2019 The pregnane X receptor (PXR) is a ligand-activated nuclear receptor that acts as a xenobiotic sensor, responding to compounds of foreign origin, including pharmaceutical compounds, environmental contaminants, and natural products, to induce ...
G. Hudson +9 more
semanticscholar +1 more source
Functional constraints on the constitutive androstane receptor inferred from human sequence variation and cross-species comparisons [PDF]
, 2005 Members of the NR1I subfamily of nuclear receptors play a role in the transcriptional activation of genes involved in drug metabolism and transport. NR1I3, the constitutive androstane receptor (CAR), mediates the induction of several genes involved in ...
Di Rienzo Anna +3 more
core +2 more sources
Plant Biology, EarlyView.Combining NMR– and LC–HRMS–based metabolomics reveals that root and leaf metabolic changes in boxwood predated by box–tree moth occur at the same density of predation for both central and specialized metabolisms. Abstract The recent biological invasion of box tree moth Cydalima perspectalis on Buxus trees has a major impact on European boxwood stands ...
A. E. Hay +12 more
wiley +1 more source
Pregnane X receptor in drug-induced liver injury: Friend or foe?
Liver Research, 2018 The pregnane X receptor (PXR) is a ligand activated nuclear receptor that is highly expressed in the liver and regulates many cellular functions including drug metabolism, endobiotic metabolism, oxidative stress response, apoptosis, inflammation, cell ...
Amina I. Shehu, Xiaochao Ma
doaj
Cell & Bioscience, 2021 Background Intestinal dysbiosis is believed to be one of the factors inducing neonatal necrotizing enterocolitis (NEC). Probiotics have been employed to treat NEC in a number of animal experiments and clinical trials, and some significant benefits of ...
Xiuhao Zhao +8 more
doaj +1 more source