Results 111 to 120 of about 16,876 (211)

Gut microbiome‐derived metabolites show promise in cancer research and therapy

Interdisciplinary Medicine, Volume 4, Issue 2, March 2026.
The metabolites produced by the gut microbiome, which are subject to regulation by multiple factors, play a pivotal role in the progression of various types of cancer. These metabolites not only function as potential biomarkers for the early detection and monitoring of tumor development, but also actively participate in cancer therapeutic processes ...
Kangjie Yang, Yifan Wang, Daolin Tang, Peilong Li, Lutao Du   +4 more
wiley   +1 more source

Impact of Efavirenz on Heme Protein Induction and Biomarkers: Insights From In Vitro Experiments and a Clinical Study

Clinical and Translational Science, Volume 19, Issue 3, March 2026.
ABSTRACT Coproporphyrin I (CPI) is increasingly recognized as a reliable endogenous biomarker for hepatic OATP1B transporters. However, confounding mechanisms such as increased heme biosynthesis driven by induction of CYP enzymes, which are hemoproteins, may affect CPI levels independently of OATP1B1 inhibition. The aim of this study was to investigate
Leila Potzel, Jonny Kinzi, Isabell Seibert, Markus Grube, Werner Siegmund, Henriette E. Meyer zu Schwabedissen   +5 more
wiley   +1 more source

Secondary metabolites with ecologic and medicinal implications in Anthemis cretica subsp. petraea from Majella National Park [PDF]

, 2016
Anthemis cretica subsp. petraea (Ten.) Greuter is a plant belonging to the Asteraceae family and endemic of central Italy. In this paper, the first analysisof the ethanolic fraction of samples collected in the Majella National Park is reported.
Alessandro Venditti, Armandodoriano Bianco, Claudio Frezza, Giacomo Rossi, Giampiero Ciaschetti, Mauro Serafini, Mirella Di Cecco, null null   +7 more
core   +2 more sources

Characterization of porcine pregnane X receptor, farnesoid X receptor and their splice variants

Experimental Biology and Medicine, 2010
The pregnane X receptor (PXR; NR1I2) and the farnesoid X receptor (FXR; NR1H4) regulate the expression of many major metabolic enzymes. With the pig being used as a model for humans in metabolic and toxicological studies and also an important food animal, we characterized the transactivation profile of the porcine orthologs of these receptors, pgPXR ...
Matthew A, Gray, Callie B, Pollock, Lawrence B, Schook, E James, Squires   +3 more
openaire   +2 more sources

Differential effects of clinically used derivatives and metabolites of artemisinin in the activation of constitutive androstane receptor isoforms [PDF]

, 2012
BACKGROUND AND PURPOSE Widespread resistance to antimalarial drugs requires combination therapies with increasing risk of pharmacokinetic drugdrug interactions.
Alexander, Arnold, Asimus, Auerbach, Auerbach, Baes, Berman, Blättler, Burk, Burk, di Masi, Dring, Elsherbiny, Faucette, Gautam, Giao, Grace, Halgren, Hesse, Hoffart, Honda, Huey, Hustert, Jyrkkärinne, Kawamoto, Kerb, Khoo, Krey, Kyle, Lee, Maglich, Moore, Morris, Navaratnam, Nussler, Pan, Pissios, Ross, Sanner, Simonsson, Skinner-Adams, Svensson, Svärd, Wang, Ward, White, WHO, WHO, Windshügel, Wolbold, Xu, Zhang   +51 more
core   +1 more source

Generation of a PXR reporter human induced pluripotent stem cell line (PXR-mCherry hiPSC) using the CRISPR/Cas9 system

Stem Cell Research, 2018
Pregnane X receptor (PXR) is a key nuclear receptor that mediates drug metabolism and stimulates hepatocyte proliferation. However, the lack of PXR expression in human pluripotent stem cell-derived hepatocytes limits their application for drug screening ...
Hyemin Kim, Ji-Woo Kim, So-Jin Kim, Young-Jun Choi, Dae-Sung Kim, Han-Jin Park   +5 more
doaj   +1 more source

Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma [PDF]

, 2004
Background Recent evidence suggests that progesterone metabolites play important roles in regulating breast cancer. Previous studies have shown that tumorous tissues have higher 5α-reductase (5αR) and lower 3α-hydroxysteroid oxidoreductase (3α-HSO) and ...
M Mori, M Mori, M Mori, M Mori, W Eechaute, K Shiota, NM Tanaka, U Verma, RV Lloyd, John P. Wiebe, John P. Wiebe, Peter J. Weiler, John P. Wiebe, Q Ji, KB Horwitz, S Andersson, DW Russell, DW Russell, AE Thigpen, T Suzuki, Y Jin, I Dufort, I Dufort, I Dufort, A Stolz, TM Penning, M Khanna, TM Penning, Y Zhang, Q Ji, DO Hardy, SMC Campbell, PH Wood, S Dhanvantari, JP Wiebe, Christine A. Beck, JP Wiebe, John P. Wiebe, Martin Kavaliers   +38 more
core   +2 more sources

Constitutive androstane receptor 1 is constitutively bound to chromatin and ‘primed’ for transactivation in hepatocytes [PDF]

, 2018
The constitutive androstane receptor (CAR) is a xenobiotic sensor expressed in hepatocytes that activates genes involved in drug metabolism, lipid homeostasis, and cell proliferation.
Acosta-Jimenez, Lourdes, Ding, Shaohong, Gerard, Marie-Apolline, Henderson, Colin J., McMahon, Michael, Moggs, Jonathan G., Terranova, Remi, Vitobello, Antonio, Wolf, C. Ronald   +8 more
core   +2 more sources

Lack of neurosteroid selectivity at δ vs. γ2-containing GABAA receptors in dentate granule neurons [PDF]

, 2020
GAB
Lu, Xinguo, Mennerick, Steven, Zorumski, Charles F   +2 more
core   +1 more source

Pregnane X Receptor and Cancer: Context-Specificity is Key

Nuclear Receptor Research, 2016
Pregnane X receptor (PXR) is an adopted orphan nuclear receptor that is activated by a wide-range of endobiotics and xenobiotics, including chemotherapy drugs. PXR plays a major role in the metabolism and clearance of xenobiotics and endobiotics in liver and intestine via induction of drug-metabolizing enzymes and drug-transporting proteins.
Satyanarayana R, Pondugula, Petr, Pavek, Sridhar, Mani   +2 more
openaire   +2 more sources