Results 111 to 120 of about 235,181 (316)
Molecular Mechanisms of the SLC13A5 Gene Transcription
Metabolites, 2021 Citrate is a crucial energy sensor that plays a central role in cellular metabolic homeostasis. The solute carrier family 13 member 5 (SLC13A5), a sodium-coupled citrate transporter highly expressed in the mammalian liver with relatively low levels in ...
Zhihui Li, Hongbing Wang
doaj +1 more source
Cargo binding promotes KDEL receptor clustering at the mammalian cell surface [PDF]
Sci. Rep. 6, 28940, 2016, 2017 Transmembrane receptor clustering is a ubiquitous phenomenon in pro- and eukaryotic cells to physically sense receptor/ligand interactions and subsequently translate an exogenous signal into a cellular response. Despite that receptor cluster formation has been described for a wide variety of receptors, ranging from chemotactic receptors in bacteria to ...
arxiv +1 more source
Indirubin-pregnane X receptor-JNK axis accelerates skin wound healing
Scientific Reports, 2019 Indirubin is a potent anti-inflammatory phytochemical derived from indigo naturalis. It is also endogenously produced in the intestine and detected in the circulation in mammals.
Yuka Tanaka +3 more
semanticscholar +1 more source
Food Science &Nutrition, Volume 13, Issue 6, June 2025.Our study explores the mechanisms by which Lycii fructus (LF) treats the comorbidity of nonalcoholic fatty liver disease (NAFLD) and diabetes mellitus (DM). Through network pharmacology, key LF ingredients were identified, including terpenoids and cryptoxanthin monoepoxide, which modulate critical signaling pathways like MAPK and PI3K‐Akt by targeting ...
Peng Sun +6 more
wiley +1 more source
Pregnane X Receptor Is SUMOylated to Repress the Inflammatory Response [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2010 Long-term treatment of patients with the macrolide antibiotic and prototypical activator of pregnane X receptor (PXR) rifampicin (Rif) inhibits the inflammatory response in liver. We show here that activation of the inflammatory response in hepatocytes strongly modulates SUMOylation of ligand-bound PXR.
Chenshu Xu, Gang Hu, Jeff L. Staudinger
openaire +3 more sources
The impact of high density receptor clusters on VEGF signaling [PDF]
EPTCS 125, 2013, pp. 37-52, 2013 Vascular endothelial growth factor (VEGF) signaling is involved in the process of blood vessel development and maintenance. Signaling is initiated by binding of the bivalent VEGF ligand to the membrane-bound receptors (VEGFR), which in turn stimulates receptor dimerization.
arxiv +1 more source
Evidence-Based Complementary and Alternative Medicine, 2019 Liver X receptor (LXR) is a nuclear receptor that regulates various biological processes, including de novo lipogenesis, cholesterol metabolism, and inflammation.
Tsai-Sung Tai +11 more
semanticscholar +1 more source
Pharmacological effect of one icv dose of Allopregnanolone in female rat: behavioural profile [PDF]
, 2015 We have previously observed that intracerebroventricular allopregnanolone (ALLO) injection produced an anxiolytic effect and inhibited sexual receptivity when the test was performed in a separate manner. Also, ALLO reverts learning deficit in female rats
Cabrera Kreiker, Ricardo Jorge +5 more
core
Regulation of biotransformation systems and ABC transporters by Benznidazole in HepG2 cells: involvement of Pregnane X-Receptor [PDF]
, 2012 Background: Benznidazole (BZL) is the only antichagasic drug available in most endemic countries. Its effect on the expression and activity of drug-metabolizing and transporter proteins has not been studied yet.
Arias, Agostina +9 more
core +2 more sources
iMetaOmics, Volume 2, Issue 2, June 2025.In this study, we explored the therapeutic effects of Parabacteroides goldsteinii (P. goldsteinii) on colitis and its underlying mechanisms. Our results indicate a significant reduction of P. goldsteinii in the stools of inflammatory bowel disease patients. We demonstrate the therapeutic potential of P.
Fujian Qin +7 more
wiley +1 more source