Results 101 to 110 of about 6,716 (130)

Pregnane X Receptor (PXR) Regulates P-Glycoprotein at the Blood-Brain Barrier: Functional Similarities between Pig and Human PXR

The Journal of Pharmacology and Experimental Therapeutics, 2009
Pharmacotherapy of central nervous system (CNS) disorders is impaired by the drug efflux transporter, P-glycoprotein, which limits drug penetration across the blood-brain barrier into the CNS. One strategy to increase brain drug levels is to modulate P-glycoprotein regulation.
Melanie, Ott, Gert, Fricker, Björn, Bauer   +2 more
openaire   +2 more sources

[Role of pregnane X receptor (PXR) in endobiotic metabolism].

Sheng li xue bao : [Acta physiologica Sinica], 2019
As a member of the nuclear receptor superfamily, the pregnane X receptor (PXR) is a ligand-activated transcription factor. PXR is highly expressed in liver and intestinal tissues, and also found in other tissues and organs, such as stomach and kidney. After heterodimerization with retinoid X receptor (RXR), PXR recruits numerous co-activating factors ...
Zhi-Lin, Luan, Xiao-Xiao, Huo, You-Fei, Guan, Xiao-Yan, Zhang   +3 more
openaire   +1 more source

Interleukin (IL)‐6 downregulates expression of the pregnane X receptor (PXR) in mice

Clinical Pharmacology & Therapeutics, 2003
Clinical Pharmacology & Therapeutics (2003) 73, P60–P60; doi:
G. Hartmann, V. Jekerle, M. Piquette‐Miller   +2 more
openaire   +1 more source

Synthetic Drugs and Natural Products as Modulators of Constitutive Androstane Receptor (Car) and Pregnane X Receptor (PXR)

Drug Metabolism Reviews, 2006
Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are members of the nuclear receptor superfamily. These transcription factors are predominantly expressed in the liver, where they are activated by structurally diverse compounds, including many drugs and endogenous substances.
Thomas K H, Chang, David J, Waxman
openaire   +2 more sources

Species differences in the induction and activation of the pregnane X receptor (PXR)

Toxicology, 2006
The pregnane X receptor (PXR) is regarded as the master regulator of the mammalian xenobiotic response. It has evolved the ability to respond to a variety of chemically unrelated endogenous and exogenous compounds, and regulate a large repertoire of genes involved in their uptake, metabolism and excretion, such as the cytochrome P450 (CYP) 3A gene ...
Anthony J. Zucker, Gordon G. Gibson, Barry Jones, Maurice Dickins, Nick Plant   +4 more
openaire   +1 more source

Evaluation of pregnane X receptor (PXR)-mediated CYP3A4 drug-drug interactions in drug development

Drug Metabolism Reviews, 2013
The increased capacity to rapidly eliminate drugs can have a profound effect on the efficacious exposure of coadministered drugs, especially in today's medical world of polypharmacy. There are numerous drug-drug interactions (DDIs) related to a loss of therapeutic efficacy and many of these are caused by pregnane X receptor (PXR)-mediated ...
openaire   +2 more sources

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly  

Breast Cancer Statistics, 2022

Ca-A Cancer Journal for Clinicians, 2022
Hyuna Sung, Kimberly D Miller, Rebecca L Siegel   +2 more
exaly  

Chimeric antigen receptor T‐cell therapy in multiple myeloma: A comprehensive review of current data and implications for clinical practice

Ca-A Cancer Journal for Clinicians, 2023

exaly  

Current treatment and recent progress in gastric cancer

Ca-A Cancer Journal for Clinicians, 2021
Smita S Joshi, Brian D Badgwell
exaly