Results 91 to 100 of about 30,346 (255)

Effects of heme oxygenase isozymes on Leydig cells steroidogenesis [PDF]

, 2009
In the present study, we demonstrate the expression of heme oxygenase (HO) isozymes, HO-1 and HO-2 (listed as HMOX1 and HMOX2 in the MGI Database), in MA-10 Leydig tumor cells and its effect on steroidogenesis. The well-known HO inducer, hemin, increased
Besio Moreno, Marcos Alberto, Cymeryng, Cora Betriz, Monzón, Casandra Margarita, Pagotto, Romina María del Luján, Pignataro, Omar Pedro, Piotrkowski, Barbara, Reche, Cecilia   +6 more
core   +1 more source

Deficient pregnenolone synthesis associated with congenital adrenal hyperplasia and organelle dysfunction

Endocrinology, Diabetes & Metabolism Case Reports, 2019
Steroid hormones are essential for the survival of all mammals. In adrenal glands and gonads, cytochrome P450 side chain cleavage enzyme (SCC or CYP11A1), catalyzes conversion of cholesterol to pregnenolone.
Himangshu S Bose, Alan M Rice, Brendan Marshall, Fadi Gebrail, David Kupshik, Elizabeth W Perry   +5 more
doaj   +1 more source

Functional Segregation of Pancreatic Microcirculation Reveals Sex‐Dependent Microhemodynamic Signatures [PDF]

Compr Physiol
Pancreatic exocrine microcirculation exhibits sexual dimorphism arising from steroid–genetic interactions. Laser Doppler flowmetry combined with wavelet analysis identifies a male passive coupling phenotype aligned with systemic pressure and a female active vasomotion phenotype driven by ERβ‐mediated, NO‐dependent oscillations.
Li Y, Wang Y, Wang B, Ouyang Q, Liu W, Xu X, Zhang X, Liu M, Xiu R.   +8 more
europepmc   +2 more sources

The Acute Responses of Different-sized Coronary Arteries to Testosterone [PDF]

, 2012
Coronary arteries supply blood to the myocardium. The blood flow within the coronary arteries is altered by various compounds produced within the body. Sex hormones such as testosterone are known to cause the relaxation of large coronary arteries.
Madanu, Sampath
core   +2 more sources

Endogenous oestrogens as neuroprotective modulators in the human retina: Evidence from transcriptomic profiling and aromatase inhibition

Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Single‐cell transcriptomics reveals that the human retina expresses a broad repertoire of steroid hormone biosynthesis and estrogen signalling genes. Functional validation in retinal explants shows that local estrogen synthesis is neuroprotective, preventing photoreceptor death and limiting microglial activation. Abstract Steroid hormones, particularly
Antolin Canto, Javier Valero‐Ochando, Rosa López‐Pedrajas, Teresa Olivar, Vicente Hernández‐Rabaza, Inmaculada Almansa, María Miranda   +6 more
wiley   +1 more source

TRPM3 channel stimulated by pregnenolone sulphate in synovial fibroblasts and negatively coupled to hyaluronan

BMC Musculoskeletal Disorders, 2010
Background Calcium-permeable channels are known to have roles in many mammalian cell types but the expression and contribution of such ion channels in synovial cells is mostly unknown.
English Anne A, Sukumar Piruthivi, Naylor Jacqueline, Majeed Yasser, Ciurtin Coziana, Emery Paul, Beech David J   +6 more
doaj   +1 more source

Steroid profiling in male wobbler mouse, a model of Amyotrophic Lateral Sclerosis [PDF]

, 2016
The Wobbler mouse is an animal model for human motoneuron diseases, especially amyotrophic lateral sclerosis (ALS), used in the investigation of both pathology and therapeutic treatment.
Aprahamian, Fanny, Cambourg, Annie, de Nicola, Alejandro Federico, Di Giorgio, Noelia Paula, Gonzalez Deniselle, Maria Claudia, Guennoun, Rachida, Liere, Philippe, Meyer, Maria, Pianos, Antoine, Schumacher, Michael   +9 more
core   +1 more source

SmI2/Sm‐Induced Reductive Silacyclization of Alkene/Diene Derivatives Using Dichlorosilanes or 1,2‐Dichlorodisilanes via Reductive Radical‐Polar Crossover

Chemistry – A European Journal, Volume 32, Issue 12, 23 March 2026.
A SmI2/Sm‐mediated silacyclization unlocks a concise route to 4–7‐membered silacycles from simple unsaturated substrates and dichlorosilanes/disilanes. The complementary functions of samarium reductants trigger a reductive radical–polar crossover, offering a versatile strategy for constructing multiple Si─C bonds efficiently.
Zhengwei Chen, Daigo Kondo, Tsutomu Mizota, Leo Onishi, Huiying Mu, Koji Miki, Akiya Ogawa, Kouichi Ohe   +7 more
wiley   +1 more source

Metabolic fate of pregnene-based steroids in the lactonization pathway of multifunctional strain Penicillium lanosocoeruleum

Microbial Cell Factories, 2018
Background Metabolic activities of microorganisms to modify the chemical structures of organic compounds became an effective tool for the production of high-valued steroidal drugs or their precursors.
Alina Świzdor, Anna Panek, Paulina Ostrowska   +2 more
doaj   +1 more source

Studies on Regioselective Binding Mode of Steroid Molecules in Homology Modeled Cytochrome P450-2C11 [PDF]

, 2009
In this study, we investigated the regioselective binding mode of steroid molecules and structure requirements for steroid molecules for 16[alpha]-hydroxylation by Cytochrome P450-2C11.
Eiichi Akaho, Hamed I. Ali, Hukihisa Fujita, Morio Yamada   +3 more
core   +1 more source