Results 11 to 20 of about 25,523 (241)

Presenilin/γ-secretase and inflammation [PDF]

Frontiers in Aging Neuroscience, 2010
Presenilins (PS) are the catalytic components of γ-secretase, an aspartyl protease that regulates through proteolytic processing the function of multiple signaling proteins.
Carlos A Saura
doaj   +4 more sources

Increasing expression of presenilin 1, β-catenin, and p-PTEN and its regulatory roles on cell invasion in gastric cancer. [PDF]

World J Gastrointest Oncol
Lin X, Lin GF, Gu FT, Li YL.
europepmc   +2 more sources

Presenilin-2 [PDF]

, 2020
National Cancer Institute
openaire   +2 more sources

Intramembrane proteolysis by presenilin and presenilin-like proteases [PDF]

Journal of Cell Science, 2003
Regulated intramembrane proteolysis is a novel mechanism involving proteases that hydrolyze their substrates in a hydrophobic environment. Presenilin (PS) 1 and PS 2 are required for intramembrane cleavage of an increasing number of type I membrane proteins, including the amyloid precursor protein of Alzheimer's disease and the Notch receptor, which ...
Weiming, Xia, Michael S, Wolfe
openaire   +2 more sources

Glycogen synthase kinase 3β (GSK3β) and presenilin (PS) are key regulators of kinesin-1-mediated cargo motility within axons

Frontiers in Cell and Developmental Biology, 2023
It has been a quarter century since the discovery that molecular motors are phosphorylated, but fundamental questions still remain as to how specific kinases contribute to particular motor functions, particularly in vivo, and to what extent these ...
Rupkatha Banerjee, Shermali Gunawardena
doaj   +1 more source

Modeling Alzheimer’s Disease in Caenorhabditis elegans

Biomedicines, 2022
Alzheimer’s disease (AD) is the most frequent cause of dementia. After decades of research, we know the importance of the accumulation of protein aggregates such as β-amyloid peptide and phosphorylated tau. We also know that mutations in certain proteins
Javier Alvarez, Pilar Alvarez-Illera, Jaime Santo-Domingo, Rosalba I. Fonteriz, Mayte Montero   +4 more
doaj   +1 more source

Trypanosoma cruzi Presenilin-Like Transmembrane Aspartyl Protease: Characterization and Cellular Localization

Biomolecules, 2020
The increasing detection of infections of Trypanosoma cruzi, the etiological agent of Chagas disease, in non-endemic regions beyond Latin America has risen to be a major public health issue.
Guilherme C. Lechuga, Paloma Napoleão-Pêgo, Carolina C. G. Bottino, Rosa T. Pinho, David W. Provance-Jr, Salvatore G. De-Simone   +5 more
doaj   +1 more source

Deregulation of Mitochondrial Calcium Handling Due to Presenilin Loss Disrupts Redox Homeostasis and Promotes Neuronal Dysfunction

Antioxidants, 2022
Mitochondrial dysfunction and oxidative stress are major contributors to the pathophysiology of neurodegenerative diseases, including Alzheimer’s disease (AD).
Kerry C. Ryan, Jocelyn T. Laboy, Kenneth R. Norman   +2 more
doaj   +1 more source

Neural Networks in Autosomal Dominant Alzheimer’s Disease: Insights From Functional Magnetic Resonance Imaging Studies

Frontiers in Aging Neuroscience, 2022
Alzheimer’s disease (AD) is the most common form of dementia, with no cure to stop its progression. Early detection, diagnosis, and intervention have become the hot spots in AD research.
Qiongqiong Qiu, Qiongqiong Qiu, Qiongqiong Qiu, Qiongqiong Qiu, Qiongqiong Qiu   +4 more
doaj   +1 more source

Loss of presenilin function is associated with a selective gain of APP function

eLife, 2016
Presenilin 1 (PS1) is an essential γ-secretase component, the enzyme responsible for amyloid precursor protein (APP) intramembraneous cleavage. Mutations in PS1 lead to dominant-inheritance of early-onset familial Alzheimer’s disease (FAD).
Carole Deyts, Mary Clutter, Stacy Herrera, Natalia Jovanovic, Anna Goddi, Angèle T Parent   +5 more
doaj   +1 more source