Results 21 to 30 of about 25,523 (241)

Signaling Functions of Intramembrane Aspartyl-Proteases

Frontiers in Cardiovascular Medicine, 2020
Intramembrane proteolysis is more than a mechanism to “clean” the membranes from proteins no longer needed. By non-reversibly modifying transmembrane proteins, intramembrane cleaving proteases hold key roles in multiple signaling pathways and often ...
Alkmini A. Papadopoulou, Regina Fluhrer, Regina Fluhrer   +2 more
doaj   +1 more source

Presenilin Deficiency Increases Susceptibility to Oxidative Damage in Fibroblasts

Frontiers in Aging Neuroscience, 2022
Alzheimer’s disease (AD) is a genetic and sporadic neurodegenerative disease characterized by extracellular amyloid-β-protein (Aβ) aggregates as amyloid plaques and neuronal loss in the brain parenchyma of patients.
Kun Zou, Sadequl Islam, Yang Sun, Yuan Gao, Tomohisa Nakamura, Hiroto Komano, Taisuke Tomita, Makoto Michikawa   +7 more
doaj   +1 more source

Versatility of presenilin 1 [PDF]

Proceedings of the National Academy of Sciences, 2017
Mutations in PSEN1 and PSEN2 genes, encoding presenilin 1 (PS1) and presenilin 2 (PS2), respectively, cause autosomal-dominant Alzheimer’s disease (ADAD) (1, 2). The precise mechanism by which PS1 mutations lead to AD is under active investigation. Multiple theories have been suggested to explain the role of PS1 and PS2 mutations on AD pathogenesis ...
Georgia R, Frost, Eitan, Wong, Yue-Ming, Li   +2 more
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Spastic paraplegia preceding PSEN1‐related familial Alzheimer's disease

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021
Introduction We investigated the frequency, neuropathology, and phenotypic characteristics of spastic paraplegia (SP) that precedes dementia in presenilin 1 (PSEN1) related familial Alzheimer's disease (AD).
Viorica Chelban, Marianthi Breza, Maria Szaruga, Jana Vandrovcova, David Murphy, Chia‐Ju Lee, Sondos Alikhwan, Thomas Bourinaris, George Vavougios, Muhammad Ilyas, Sobia Ahsan Halim, Ahmed Al‐Harrasi, Chrisoula Kartanou, Coras Ronald, Ingmar Blumcke, Athanasia Alexoudi, Stylianos Gatzonis, Leonidas Stefanis, Georgia Karadima, Nicholas W. Wood, Lucía Chávez‐Gutiérrez, John Hardy, Henry Houlden, Georgios Koutsis   +23 more
doaj   +1 more source

Heparan Sulfate Structure Affects Autophagy, Lifespan, Responses to Oxidative Stress, and Cell Degeneration in Drosophila parkin Mutants

G3: Genes, Genomes, Genetics, 2020
Autophagy is a catabolic process that provides cells with energy and molecular building blocks during nutritional stress. Autophagy also removes misfolded proteins and damaged organelles, a critical mechanism for cellular repair.
Claire Reynolds-Peterson, Jie Xu, Na Zhao, Casey Cruse, Brandon Yonel, Claire Trasorras, Hidenao Toyoda, Akiko Kinoshita-Toyoda, Jennifer Dobson, Nicholas Schultheis, Mei Jiang, Scott Selleck   +11 more
doaj   +1 more source

Presenilin-ryanodine receptor connection [PDF]

Proceedings of the National Academy of Sciences, 2013
The Presenilins (PS) gene family is composed of two members: PS1 and PS2. Mutations in PSs are linked to familial Alzheimer's disease (FAD) (1). PSs are the catalytic subunits of the γ-secretase multimolecular complex, which mediates the intramembranous cleavage of many type I membrane proteins, including amyloid precursor protein (APP) and Notch (2, 3)
Luciano, D'Adamio, Pablo E, Castillo
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The presenilins.

Genome biology, 2002
The presenilins are evolutionarily conserved transmembrane proteins that regulate cleavage of certain other proteins in their transmembrane domains. The clinical significance of this regulation is shown by the contribution of presenilin mutations to 20-50% of early-onset cases of inherited Alzheimer's disease.
Tandon, Anurag, Fraser, Paul
openaire   +2 more sources

Presenilin: RIP and beyond [PDF]

Seminars in Cell & Developmental Biology, 2009
Over the years the presenilins (PSENs), a family of multi-transmembrane domain proteins, have been ascribed a number of diverse potential functions. Recent in vivo evidence has supported the existence of PSEN functions beyond its well-established role in regulated intramembrane proteolysis. In this review, we will briefly discuss the ability of PSEN to
Matthew R, Hass, Chihiro, Sato, Raphael, Kopan, Guojun, Zhao   +3 more
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Presenilin‐directed inhibitors of γ‐secretase trigger caspase 3 activation in presenilin‐expressing and presenilin‐deficient cells [PDF]

Journal of Neurochemistry, 2004
AbstractThe amyloid β peptide (Aβ) is generated by subsequent cleavages by β‐ and γ‐secretases. Therefore, these two enzymes are putative therapeutic targets to prevent Aβ production, and hopefully to slow down or even stop the Alzheimer's disease (AD) neurodegenerative process.
Cristine, Alves da Costa, Erwan, Ayral, Jean-François, Hernandez, Peter, St George-Hyslop, Frédéric, Checler   +4 more
openaire   +2 more sources

Presenilin 2 overexpression is associated with apoptosis in Neuro2a cells

Translational Neuroscience, 2016
Presenilin 1 (PS1) and PS2 are evolutionarily conserved transmembrane proteins of the aspartyl protease family. Initially, they were reported to be associated with the early onset of familial, early-onset Alzheimer’s disease.
Kumar Ashish, Sivanandam T. M., Thakur M. K.   +2 more
doaj   +1 more source