Results 61 to 70 of about 25,523 (241)

Consequences of Amyloid‐β Deficiency for the Liver

Advanced Science
The hepatic content of amyloid beta (Aβ) decreases drastically in human and rodent cirrhosis highlighting the importance of understanding the consequences of Aβ deficiency in the liver.
Gayane Hrachia Buniatian, Ute Schwinghammer, Roman Tremmel, Holger Cynis, Thomas S. Weiss, Ralf Weiskirchen, Volker M. Lauschke, Sonia Youhanna, Isbaal Ramos, Maria Valcarcel, Torgom Seferyan, Jens‐Ulrich Rahfeld, Vera Rieckmann, Kathrin Klein, Marine Buadze, Victoria Weber, Valentina Kolak, Rolf Gebhardt, Scott L. Friedman, Ulrike C. Müller, Matthias Schwab, Lusine Danielyan   +21 more
doaj   +1 more source

Alzheimer’s disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling

eLife
Amyloid β (Aβ) peptides accumulating in the brain are proposed to trigger Alzheimer’s disease (AD). However, molecular cascades underlying their toxicity are poorly defined.
Katarzyna Marta Zoltowska, Utpal Das, Sam Lismont, Thomas Enzlein, Masato Maesako, Mei CQ Houser, Maria Luisa Franco, Burcu Özcan, Diana Gomes Moreira, Dmitry Karachentsev, Ann Becker, Carsten Hopf, Marçal Vilar, Oksana Berezovska, William Mobley, Lucía Chávez-Gutiérrez   +15 more
doaj   +1 more source

γ-Secretase Studied by Atomistic Molecular Dynamics Simulations: Global Dynamics, Enzyme Activation, Water Distribution and Lipid Binding

Frontiers in Chemistry, 2019
γ-secretase, an intramembrane-cleaving aspartyl protease is involved in the cleavage of a large number of intramembrane proteins. The most prominent substrate is the amyloid precursor protein, whose proteolytic processing leads to the production of ...
Manuel Hitzenberger, Martin Zacharias
doaj   +1 more source

ABCA7—A Member of the ABC Transporter Family in Healthy and Ailing Brain

Brain Sciences, 2020
Identification of genetic markers of a human disease, which is generally sporadic, may become an essential tool for the investigation of its molecular mechanisms.
Alexei A. Surguchev, Andrei Surguchov
doaj   +1 more source

Discovery of novel benzophenone integrated derivatives as anti-Alzheimer's agents targeting presenilin-1 and presenilin-2 inhibition: A computational approach.

PLoS ONE, 2022
The most commonly accepted hypothesis of Alzheimer's disease (AD) is the amyloid hypothesis caused due to formation of accumulation of Aβ42 isoform, which leads to neurodegeneration.
Reshma Mary Martiz, Shashank M Patil, Ramith Ramu, Jayanthi M K, Ashwini P, Lakshmi V Ranganatha, Shaukath Ara Khanum, Ekaterina Silina, Victor Stupin, Raghu Ram Achar   +9 more
doaj   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Gains and losses on the road to understanding Alzheimer’s disease

Swiss Medical Weekly, 2015
Alzheimer’s disease (AD) is a neurodegenerative disorder and the most common cause for dementia, which affects approximately 120 thousand people in Switzerland and 35 million worldwide.
Uwe Konietzko
doaj   +1 more source

Rapamycin Reduces Amyloid‐β Plaques and Improves Behavioral Performance in a Sex‐Dependent Manner in Mouse Models of Amyloidosis

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Rapamycin treatment reduced cerebral Aβ plaque burden, alleviated neuritic dystrophy, suppressed glial hyperactivation, and increased plaque‐associated microglial recruitment in amyloidosis mouse models, resulting in improved memory performance. Mechanistically, rapamycin enhanced microglial lysosomal degradation, facilitated lipid droplet clearance in
Shihui Guo, Weishan Fu, Yating Wang, Qi Liu, Jiaxin Li, Kai Guo, Hongsheng Zhang   +6 more
wiley   +1 more source

Pleiotropy of Presenilins [PDF]

Hereditary Genetics, 2013
Pleiotropy genes affect multiple and apparently unrelated phenotypes. Here we describe pleiotropy gene presenilins, mutations in which have been detected in three genetically heterogeneous diseases: early-onset familial Alzheimer’s disease, familial or sporadic dilated cardiomyopathy, and familial hidradenitis suppurativa.
openaire   +1 more source

How γ-secretase hits a moving target

eLife, 2016
An improved understanding of the ways that amyloid-beta peptides are formed could help efforts to find a treatment for Alzheimer’s disease.
Charles R Sanders
doaj   +1 more source